Abstract
The vertebral column from a known case of Wilson's disease (hepatolenticular degeneration) was examined by radiological, histological, histochemical and x-ray microanalytical techniques which demonstrated the presence of focal depositions of calcium pyrophosphate dihydrate (CPPD) in the intervertebral discs. These deposits were present in both the annulus fibrosus and the nucleus pulposus but in certain discs the deposits were concentrated near the interface between disc and vertebral body bone endplates. At these sites there was new bone formation with narrowing of the discs, irregularity and sclerosis of the bone endplates and exostosis.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chaplin A. J. Calcium pyrophosphate. Histological characterization of crystals in pseudogout. Arch Pathol Lab Med. 1976 Jan;100(1):12–15. [PubMed] [Google Scholar]
- Crocker P. R., Dieppe P. A., Tyler G., Chapman S. K., Willoughby D. A. The identification of particulate matter in biological tissues and fluids. J Pathol. 1977 Jan;121(1):37–40. doi: 10.1002/path.1711210106. [DOI] [PubMed] [Google Scholar]
- Currey H. L. Examination of joint fluids for crystals. Proc R Soc Med. 1968 Oct;61(10):969–971. doi: 10.1177/003591576806101006. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dieppe P. A., Crocker P., Huskisson E. C., Willoughby D. A. Apatite deposition disease. A new arthropathy. Lancet. 1976 Feb 7;1(7954):266–269. doi: 10.1016/s0140-6736(76)91400-8. [DOI] [PubMed] [Google Scholar]
- Feller E. R., Schumacher H. R. Osteoarticular changes in Wilson's disease. Arthritis Rheum. 1972 May-Jun;15(3):259–266. doi: 10.1002/art.1780150307. [DOI] [PubMed] [Google Scholar]
- Hoffman G. S., Schumacher H. R., Paul H., Cherian V., Reed R., Ramsay A. G., Franck W. A. Calcium oxalate microcrystalline-associated arthritis in end-stage renal disease. Ann Intern Med. 1982 Jul;97(1):36–42. doi: 10.7326/0003-4819-97-1-36. [DOI] [PubMed] [Google Scholar]