Introduction: The threat of lymph node positivity (LN+) in rectal cancer is a factor that blows therapeutic references. We intended to compute the outcome of younger age on LN+ in rectal tumor.
Methods: The patients with rectal tumor detected between 1997 and 2007 were recognized by means of the Surveillance, Epidemiology, and End Results (SEER) database. They were phase I–III, with no preoperative radiotherapy, no less than one lymph node inspected, and a typical rectal tumor operation achieved. The alliance of age and LN+ rank was inspected with logistic regression individually for every T stage, regulating for numerous covariates. Poisson regression was applied to appraise age and quantity of positive lymph nodes (LNs). Every statistical test was two-sided.
Results: Forty-seven thousand sixty-six patients were recognized, counting 1385 (2.5%) patients age 20 to 40 years at diagnosis and 3381(7.4%) patients age 40 to 49 years (defined as juvenile). For every T period, LN+ was inversely connected to age (all P < .001). For T1, T2, and T3, age remained projecting LN+ status after alteration for quantity of LNs observed and further covariates (P < 0.005 for every phase). Accustomed odds ratios (ORs) for LN+ for age 20 to 40 vs 60 to 69 were: T1: 1.87 (95% confidence interval [CI] = 1.28 to 2.75); T2: 1.34 (95% CI = 1.12 to 1.87); T3: 1.20 (95% CI = 1.07 to 1.53). Youthful age was a statistically important forecaster of an augmented figure of LNs positive for phase T2 (P = .036) and T3 (P = .001).
Conclusion: In this huge nationwide dataset, youthful age at diagnosis is linked to an augmented hazard of LN+. This discovery is worth additional research and may eventually blow management of decision policy for juvenile early-phase patients.