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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Oct;36(10):1171–1175. doi: 10.1136/jcp.36.10.1171

Giant cell tumour (osteoclastoma) of the pancreas--an epithelial tumour probably of pancreatic acinar origin.

S S Jalloh
PMCID: PMC498496  PMID: 6619313

Abstract

A case of giant cell tumour of the pancreas has been studied. The light microscopical appearance of the tumour is indistinguishable from osteoclastoma of bone. Electron microscopy of the tumour shows many typical desmosomes between stromal cells. This is strong evidence of its epithelial nature. The cytoplasm of both the osteoclast-like giant cells and stromal cells contain abundant rough endoplasmic reticulum, many with dilated cisternae containing prominent dense granules. There are also some larger homogeneous granules, some of them electron-dense, in the cytoplasm of the cells. These findings when compared with the features of other cases of giant cell tumour of the pancreas studied by electron microscopy support the view that this epithelial tumour is of acinar origin.

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Selected References

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  1. Alguacil-Garcia A., Weiland L. H. The histologic spectrum, prognosis, and histogenesis of the sarcomatoid carcinoma of the pancreas. Cancer. 1977 Mar;39(3):1181–1189. doi: 10.1002/1097-0142(197703)39:3<1181::aid-cncr2820390325>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  2. Eshun-Wilson K. Malignant giant-cell tumour of the colon. Acta Pathol Microbiol Scand A. 1973 Mar;81(2):137–144. doi: 10.1111/j.1699-0463.1973.tb00004.x. [DOI] [PubMed] [Google Scholar]
  3. Factor S. M., Biempica L., Ratner I., Ahuja K. K., Biempica S. Carcinoma of the breast with multinucleated reactive stromal giant cells. A light and electron microscopic study of two cases. Virchows Arch A Pathol Anat Histol. 1977 May 13;374(1):1–12. doi: 10.1007/BF00430566. [DOI] [PubMed] [Google Scholar]
  4. Gaal J. M., Horvath E., Kovacs K. Ultrastructure of two cases of anaplastic giant cell tumor of the human thyroid gland. Cancer. 1975 May;35(5):1273–1279. doi: 10.1002/1097-0142(197505)35:5<1273::aid-cncr2820350502>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  5. Guccion J. G., Enzinger F. M. Malignant giant cell tumor of soft parts. An analysis of 32 cases. Cancer. 1972 Jun;29(6):1518–1529. doi: 10.1002/1097-0142(197206)29:6<1518::aid-cncr2820290616>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  6. Guillan R. A. Pleomorphic adenocarcinoma of the pancreas. An analysis of five cases. Cancer. 1968 Jun;21(6):1072–1079. doi: 10.1002/1097-0142(196806)21:6<1072::aid-cncr2820210608>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  7. Hanaoka H., Friedman B., Mack R. P. Ultrastructure and histogenesis of giant-cell tumor of bone. Cancer. 1970 Jun;25(6):1408–1423. doi: 10.1002/1097-0142(197006)25:6<1408::aid-cncr2820250622>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  8. Holtz F., Fox J. E., Abell M. R. Carcinosarcoma of the urinary bladder. Cancer. 1972 Feb;29(2):294–304. doi: 10.1002/1097-0142(197202)29:2<294::aid-cncr2820290205>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  9. Levin D. L., Connelly R. R. Cancer of the pancreas. Available epidemiologic information and its implications. Cancer. 1973 May;31(5):1231–1236. doi: 10.1002/1097-0142(197305)31:5<1231::aid-cncr2820310529>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  10. Levin D. L., Connelly R. R., Devesa S. S. Demographic characteristics of cancer of the pancreas: mortality, incidence, and survival. Cancer. 1981 Mar 15;47(6 Suppl):1456–1468. doi: 10.1002/1097-0142(19810315)47:6+<1456::aid-cncr2820471404>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  11. Levison D. A. Carcinoma of the pancreas. J Pathol. 1979 Dec;129(4):203–223. doi: 10.1002/path.1711290406. [DOI] [PubMed] [Google Scholar]
  12. NASH A. D., STOUT A. P. Giant cell carcinoma of the lung; report of 5 cases. Cancer. 1958 Mar-Apr;11(2):369–376. doi: 10.1002/1097-0142(195803/04)11:2<369::aid-cncr2820110222>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  13. Nishiyama R. H., Dunn E. L., Thompson N. W. Anaplastic spindle-cell and giant-cell tumors of the thyroid gland. Cancer. 1972 Jul;30(1):113–127. doi: 10.1002/1097-0142(197207)30:1<113::aid-cncr2820300118>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  14. Robinson L., Damjenov I., Brezina P. Multinucleated giant cell neoplasm of pancreas: light and electron microscopy features. Arch Pathol Lab Med. 1977 Nov;101(11):590–593. [PubMed] [Google Scholar]
  15. Rosai J. Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin. Cancer. 1968 Aug;22(2):333–344. doi: 10.1002/1097-0142(196808)22:2<333::aid-cncr2820220210>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  16. Salm R., Sissons H. A. Giant-cell tumours of soft tissues. J Pathol. 1972 May;107(1):27–39. doi: 10.1002/path.1711070106. [DOI] [PubMed] [Google Scholar]
  17. Silverberg S. G., DeGiorgi L. S. Osteoclastoma-like giant cell tumor of the thyroid. Report of a case with prolonged survival following partial excision and radiotherapy. Cancer. 1973 Mar;31(3):621–625. doi: 10.1002/1097-0142(197303)31:3<621::aid-cncr2820310319>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  18. Trepeta R. W., Mathur B., Lagin S., LiVolsi V. A. Giant cell tumor ("osteoclastoma") of the pancreas: a tumor of epithelial origin. Cancer. 1981 Nov 1;48(9):2022–2028. doi: 10.1002/1097-0142(19811101)48:9<2022::aid-cncr2820480919>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  19. Tschang T. P., Garza-Garza R., Kissane J. M. Pleomorphic carcinoma of the pancreas: an analysis of 15 cases. Cancer. 1977 May;39(5):2114–2126. doi: 10.1002/1097-0142(197705)39:5<2114::aid-cncr2820390528>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  20. Urbanski S. J., Medline A. Giant cell carcinoma of pancreas with clear cell pattern in metastases. Hum Pathol. 1982 Nov;13(11):1047–1049. doi: 10.1016/s0046-8177(82)80099-3. [DOI] [PubMed] [Google Scholar]
  21. Webb J. N. Acinar cell neoplasms of the exocrine pancreas. J Clin Pathol. 1977 Feb;30(2):103–112. doi: 10.1136/jcp.30.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]

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