Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Nov;36(11):1288–1291. doi: 10.1136/jcp.36.11.1288

Bone marrow aluminium storage in renal failure.

M Kaye
PMCID: PMC498547  PMID: 6630578

Abstract

Using the staining method for aluminium with the ammonium salt of aurine tricarboxylic acid, aluminon, 18 patients with end stage renal disease gave positive reactions in iliac crest bone biopsies and 11 of these had positive staining in the bone marrow. In one the marrow was positive and the bone negative. The marrow reaction is putatively regarded as caused by aluminium storage in unidentified cells, possibly of the macrophage system which are strongly fluorescent when examined after prior tetracycline labelling. Marrow storage should be considered when assessing the bone aluminium burden.

Full text

PDF
1288

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buchanan M. R., Ihle B. U., Dunn C. M. Haemodialysis related osteomalacia: a staining method to demonstrate aluminium. J Clin Pathol. 1981 Dec;34(12):1352–1354. doi: 10.1136/jcp.34.12.1352. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cournot-Witmer G., Zingraff J., Plachot J. J., Escaig F., Lefèvre R., Boumati P., Bourdeau A., Garabédian M., Galle P., Bourdon R. Aluminum localization in bone from hemodialyzed patients: relationship to matrix mineralization. Kidney Int. 1981 Sep;20(3):375–378. doi: 10.1038/ki.1981.149. [DOI] [PubMed] [Google Scholar]
  3. Fallon M. D., Teitelbaum S. L. A simple procedure for the rapid histologic diagnosis of metabolic bone disease. Calcif Tissue Int. 1981;33(3):281–283. doi: 10.1007/BF02409450. [DOI] [PubMed] [Google Scholar]
  4. Leong A. S., Disney A. P., Gove D. W. Refractile particles in liver of haemodialysis patients. Lancet. 1981 Apr 18;1(8225):889–890. doi: 10.1016/s0140-6736(81)92155-3. [DOI] [PubMed] [Google Scholar]
  5. Maloney N. A., Ott S. M., Alfrey A. C., Miller N. L., Coburn J. W., Sherrard D. J. Histological quantitation of aluminum in iliac bone from patients with renal failure. J Lab Clin Med. 1982 Feb;99(2):206–216. [PubMed] [Google Scholar]
  6. Smith P. S., McClure J. Localisation of aluminium by histochemical and electron probe x-ray microanalytical techniques in bone tissue of cases of renal osteodystrophy. J Clin Pathol. 1982 Nov;35(11):1283–1293. doi: 10.1136/jcp.35.11.1283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Westen H., Mück K. F., Post L. Enzyme histochemistry on bone marrow sections after embedding in methacrylate at low temperature. Histochemistry. 1981;70(2):95–105. doi: 10.1007/BF00493201. [DOI] [PubMed] [Google Scholar]
  8. Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES