Table 5.

β2*-nAChR interacting proteins identified by iTRAQ analysis of receptors isolated from transgenic mouse cortex receiving long-term treatment with nicotine and not receiving nicotine treatment (GN, gene name)

Accession	Description	Correlation (r)	p Value
sp|O70174|ACHA4_MOUSE	Neuronal acetylcholine receptor subunit α4 OS = Mus musculus GN = Chrna4 PE = 2 SV = 2	0.97	<0.0009
sp|Q2MKA5|ACHA5_MOUSE	Neuronal acetylcholine receptor subunit α5 OS = Mus musculus GN = Chrna5 PE = 2 SV = 1	0.91	<0.0009
sp|Q9ERK7|ACHB2_MOUSE	Neuronal acetylcholine receptor subunit β2 OS = Mus musculus GN = Chrnb2 PE = 2 SV = 1	1	<0.0009
sp|Q6PIC6|AT1A3_MOUSE	Sodium/potassium-transporting ATPase subunit α3 OS = Mus musculus GN = Atp1a3 PE = 1 SV = 1	0.55	0.042
sp|Q62277|SYPH_MOUSE	Synaptophysin OS = Mus musculus GN = Syp PE = 1 SV = 2	0.59	0.026

Similar to the results from human cortex samples, presynaptic elements related to vesicle fusion (synaptophysin) and neuronal excitability (ATP1A3) are significantly correlated with nAChR levels.