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. 1983 Dec;36(12):1342–1349. doi: 10.1136/jcp.36.12.1342

Microdeposits of amyloid in sclerocalcific heart valves: a histochemical and immunofluorescence study.

Y A Goffin, W Murdoch, G G Cornwell 3rd, G D Sorenson
PMCID: PMC498565  PMID: 6361072

Abstract

Amyloid associated with seven sclerotic and two normal aortic and mitral valves was studied. The sclerotic valve amyloid contained microfibrils with typical random orientation and a fibril width of 9.5-12.5 nm. The amyloid deposits demonstrated permanganate-resistant Congophilia and contained the amino acid tryptophan. Immunofluorescence studies showed P-component in amyloid deposits of 6 of 7 valves, but none of the sclerotic valves contained amyloid fibril proteins of the AL (primary), AA (secondary), AEt (medullary thyroid carcinoma) or ASc1 (senile cardiac) types. Two non-sclerotic valves, removed from a patient with systemic amyloidosis, showed permanganate-sensitive Congophilic amyloid deposits which contained amyloid fibril protein AA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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