Abstract
A case of primary tumorous aldosteronism due to a black adrenal adenoma in a 37-year-old man is reported. Light microscopy showed the tumour to consist predominantly of compact cells containing intracytoplasmic lipofuscin, accompanied by zona fasciculata and intermediate type cells. Electron microscopy identified compact and interface (inner zona fasciculata) type cells, and also demonstrated spironolactone bodies in a compact cell. The morphological appearance of the tumour and adjacent adrenal gland, combined with the clinical and biochemical findings, supports both its secretory function and its classification as a rare variant of the more common non-pigmented aldosteronoma.
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- Bahu R. M., Battifora H., Shambaugh G., 3rd Functional black adenoma of the adrenal gland. Light and electron microscopical study. Arch Pathol. 1974 Aug;98(2):139–142. [PubMed] [Google Scholar]
- Cain D. R., Van de Velde R. L., Shapiro S. J. Spironolactone inclusions in an aldosteronoma. Am J Clin Pathol. 1974 Mar;61(3):412–416. doi: 10.1093/ajcp/61.3.412. [DOI] [PubMed] [Google Scholar]
- Caplan R. H., Virata R. L. Functional black adenoma of the adrenal cortex. A rare cause of primary aldosteronism. Am J Clin Pathol. 1974 Jul;62(1):97–103. doi: 10.1093/ajcp/62.1.97. [DOI] [PubMed] [Google Scholar]
- Conn J. W., Hinerman D. L. Spironolactone-induced inhibition of aldosterone biosynthesis in primary aldosteronism: morphological and functional studies. Metabolism. 1977 Dec;26(12):1293–1307. doi: 10.1016/0026-0495(77)90026-9. [DOI] [PubMed] [Google Scholar]
- Ferriss J. B., Brown J. J., Fraser R., Kay A. W., Neville A. M., O'Muircheartaigh I. G., Robertson J. I., Symington T., Lever A. F. Hypertension with aldosterone excess and low plasma-renin: preoperative distinction between patients with and without adrenocortical tumour. Lancet. 1970 Nov 14;2(7681):995–1000. doi: 10.1016/s0140-6736(70)92811-4. [DOI] [PubMed] [Google Scholar]
- Lui K. K., Shikata K., Amano T. [Black adenoma and pigmented nodules of the adrenal cortex (author's transl)]. Fukuoka Igaku Zasshi. 1980 Oct;71(10):583–591. [PubMed] [Google Scholar]
- Macadam R. F. Black adenoma of the human adrenal cortex. Cancer. 1971 Jan;27(1):116–119. doi: 10.1002/1097-0142(197101)27:1<116::aid-cncr2820270117>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- McDowell E. M., Trump B. F. Histologic fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med. 1976 Aug;100(8):405–414. [PubMed] [Google Scholar]
- Neville A. M., Symington T. Pathology of primary aldosteronism. Cancer. 1966 Dec;19(12):1854–1868. doi: 10.1002/1097-0142(196612)19:12<1854::aid-cncr2820191213>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
- Robinson M. J., Pardo V., Rywlin A. M. Pigmented nodules (black adenomas) of the adrenal. An autopsy study of incidence, morphology, and function. Hum Pathol. 1972 Sep;3(3):317–325. doi: 10.1016/s0046-8177(72)80033-9. [DOI] [PubMed] [Google Scholar]
- Sasano N., Ojima M., Masuda T. Endocrinologic pathology of functioning adrenocortical tumors. Pathol Annu. 1980;15(Pt 2):105–141. [PubMed] [Google Scholar]
- Shapiro B., Britton K. E., Hawkins L. A., Edwards C. R. Clinical experience with 75Se selenomethylcholesterol adrenal imaging. Clin Endocrinol (Oxf) 1981 Jul;15(1):19–27. doi: 10.1111/j.1365-2265.1981.tb02743.x. [DOI] [PubMed] [Google Scholar]
- Shrago S. S., Waisman J., Cooper P. H. Spironolactone bodies in an adrenal adenoma. Arch Pathol. 1975 Aug;99(8):416–420. [PubMed] [Google Scholar]
- Tsuchiyama H., Kawai K., Harada T., Shigematsu K., Sugihara H. Functional pathology of aldosterone-producing adenoma. Acta Pathol Jpn. 1980 Nov;30(6):967–976. doi: 10.1111/j.1440-1827.1980.tb03284.x. [DOI] [PubMed] [Google Scholar]
- Uras A., Budak D., Ariogul O., Görpe A., Tahsinoğlu M. A functioning black adenoma of the adrenal gland. Clin Oncol. 1978 Jun;4(2):181–186. [PubMed] [Google Scholar]
- Visser J. W., Boeijinga K. D., Meer C. V. A functioning black adenoma of the adrenal cortex: a clinico-pathological entity. J Clin Pathol. 1974 Dec;27(12):955–959. doi: 10.1136/jcp.27.12.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zaniewski M., Sheeler L. R. Cushing's syndrome associated with functional black adenoma of the adrenal cortex. South Med J. 1980 Oct;73(10):1410–1412. doi: 10.1097/00007611-198010000-00038. [DOI] [PubMed] [Google Scholar]






