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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1984 Apr;37(4):463–466. doi: 10.1136/jcp.37.4.463

Serum paraproteins in chronic lymphocytic leukaemia.

D Sinclair, J H Dagg, A M Mowat, D M Parrott, D I Stott
PMCID: PMC498753  PMID: 6707229

Abstract

The presence of paraproteins in the sera of 10 patients with chronic lymphocytic leukaemia (CLL) was investigated using immunoisoelectric focusing. Monoclonal immunoglobulins were found in nine of these 10 sera. Five sera contained a single monoclonal IgM paraprotein, one serum contained a single monoclonal IgG paraprotein, while three sera contained more than one monoclonal paraprotein--namely, IgM + IgD, IgM + IgG, and IgM + IgD + IgG. The results indicate that the malignant B cells of CLL may be at a later stage of differentiation than previously assumed and serum monoclonal immunoglobulin could be of value as a tumour marker.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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