Abstract
The relation between the timing of prophylactic antibiotic administration and the occurrence of bacteraemia during transurethral operations was studied in 112 patients whose urine was infected before operation. Blood cultures taken during operation were positive in 15 (60%) of 25 patients who did not receive appropriate antibiotics, in 13 (21%) of 63 patients who were given appropriate antibiotics less than 24 h before operation, and in none of 24 patients in whom antibiotic "cover" was started more than 24 h before operation. In all cases the bacteraemia was transient. No patient developed septicaemia. The implications of these findings for the optimum timing of antibiotic administration to patients with preoperative bacteriuria are discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cafferkey M. T., Conneely B., Falkiner F. R., Gillespie W. A., Murphy D. Post-operative urinary infection and septicaemia in urology. J Hosp Infect. 1980 Dec;1(4):315–320. doi: 10.1016/0195-6701(80)90007-9. [DOI] [PubMed] [Google Scholar]
- Cafferkey M. T., Falkiner F. R., Gillespie W. A., Murphy D. M. Antibiotics for the prevention of septicaemia in urology. J Antimicrob Chemother. 1982 Jun;9(6):471–477. doi: 10.1093/jac/9.6.471. [DOI] [PubMed] [Google Scholar]
- Curie K., Speller D. C., Simpson R. A., Stephens M., Cooke D. I. A hospital epidemic caused by gentamicin-resistant Klebsiella aerogenes. J Hyg (Lond) 1978 Feb;80(1):115–123. doi: 10.1017/s0022172400053432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gordon A. M. Gentamicin-resistant Klebsiella strains in a hospital. Br Med J. 1980 Mar 8;280(6215):722–723. [PubMed] [Google Scholar]
- Keighley M. R. Perioperative antibiotics. Br Med J (Clin Res Ed) 1983 Jun 11;286(6381):1844–1846. doi: 10.1136/bmj.286.6381.1844-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lowes J. A., Smith J., Tabaqchali S., Shaw E. J. Outbreak of infection in a urological ward. Br Med J. 1980 Mar 8;280(6215):722–722. [PMC free article] [PubMed] [Google Scholar]
- Murphy D. M., Falkiner F. R., Carr M., Cafferkey M. T., Gillespie W. A. Septicemia after transurethral prostatectomy. Urology. 1983 Aug;22(2):133–135. doi: 10.1016/0090-4295(83)90493-4. [DOI] [PubMed] [Google Scholar]
- SLADE N. Bacteriaemia and septicaemia after urological operations. Proc R Soc Med. 1958 May;51(5):331–334. doi: 10.1177/003591575805100507. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sullivan N. M., Sutter V. L., Mims M. M., Marsh V. H., Finegold S. M. Clinical aspects of bacteremia after manipulation of the genitourinary tract. J Infect Dis. 1973 Jan;127(1):49–55. doi: 10.1093/infdis/127.1.49. [DOI] [PubMed] [Google Scholar]
- TALBOT C. H. Septicaemia due to gram-negative bacilli. Lancet. 1962 Mar 31;1(7231):668–670. doi: 10.1016/s0140-6736(62)92882-9. [DOI] [PubMed] [Google Scholar]