Abstract
Immunoglobulin has been measured and studied electrophoretically in cerebrospinal fluid (CSF) from 14 patients with Alzheimer's disease and 25 undemented controls. Presence or absence of the diagnosis of Alzheimer's disease was confirmed histologically, as these were postmortem specimens. There was no increased incidence of oligoclonal IgG bands in either group, and no significant differences in the levels of IgG and albumin. Non-immunoglobulin bands were found in the gamma region in some samples from Alzheimer's disease patients and controls; such bands are not found in the CSF from younger patients. There was a significantly increased incidence of double transferrin and double tau protein bands in the Alzheimer's group, suggesting that further studies of genetic markers might be worthwhile.
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- Chu A. B., Sever J. L., Madden D. L., Iivanainen M., Leon M., Wallen W., Brooks B. R., Lee Y. J., Houff S. Oligoclonal IgG bands in cerebrospinal fluid in various neurological diseases. Ann Neurol. 1983 Apr;13(4):434–439. doi: 10.1002/ana.410130410. [DOI] [PubMed] [Google Scholar]
- Henschke P. J., Bell D. A., Cape R. D. Alzheimer's disease and HLA. Tissue Antigens. 1978 Aug;12(2):132–135. doi: 10.1111/j.1399-0039.1978.tb01308.x. [DOI] [PubMed] [Google Scholar]
- Nerl C. W., Mayeux R., O'Neill G. J. Complement C4 allotypes in Alzheimer's disease. Lancet. 1982 Dec 11;2(8311):1343–1343. doi: 10.1016/s0140-6736(82)91546-x. [DOI] [PubMed] [Google Scholar]
- Roström B., Link B. Oligoclonal immunoglobulins in cerebrospinal fluid in acute cerebrovascular disease. Neurology. 1981 May;31(5):590–596. doi: 10.1212/wnl.31.5.590. [DOI] [PubMed] [Google Scholar]
- Sulkava R., Koskimies S., Wikström J., Palo J. HLA antigens in Alzheimer's disease. Tissue Antigens. 1980 Aug;16(2):191–194. doi: 10.1111/j.1399-0039.1980.tb00602.x. [DOI] [PubMed] [Google Scholar]
- Thompson E. J., Kaufmann P., Shortman R. C., Rudge P., McDonald W. I. Oligoclonal immunoglobulins and plasma cells in spinal fluid of patients with multiple sclerosis. Br Med J. 1979 Jan 6;1(6155):16–17. doi: 10.1136/bmj.1.6155.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thompson E. J., Riches P. G., Kohn J. Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis. J Clin Pathol. 1983 Mar;36(3):312–315. doi: 10.1136/jcp.36.3.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilcock G. K., Esiri M. M., Bowen D. M., Smith C. C. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J Neurol Sci. 1982 Dec;57(2-3):407–417. doi: 10.1016/0022-510x(82)90045-4. [DOI] [PubMed] [Google Scholar]
- Wilcock G. K., Esiri M. M. Plaques, tangles and dementia. A quantitative study. J Neurol Sci. 1982 Nov;56(2-3):343–356. doi: 10.1016/0022-510x(82)90155-1. [DOI] [PubMed] [Google Scholar]
- Williams A., Papadopoulos N., Chase T. N. Demonstration of CSF gamma-globulin banding in presenile dementia. Neurology. 1980 Aug;30(8):882–884. doi: 10.1212/wnl.30.8.882. [DOI] [PubMed] [Google Scholar]