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. 1984 Sep;37(9):1032–1034. doi: 10.1136/jcp.37.9.1032

Idiopathic acquired sideroblastic anaemia transforming to acute myelosclerosis.

A C Bested, G Cheng, P H Pinkerton, O Kassim, J S Senn
PMCID: PMC498922  PMID: 6470180

Abstract

A case of idiopathic acquired sideroblastic anaemia transforming to acute myelofibrosis is reported. The appearance of atypical megakaryocytic proliferation in idiopathic acquired sideroblastic anaemia may presage the development of an acute myelofibrotic phase of this usually chronic disease.

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Selected References

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  1. Bain B. J., Catovsky D., O'Brien M., Prentice H. G., Lawlor E., Kumaran T. O., McCann S. R., Matutes E., Galton D. A. Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reaction. Blood. 1981 Aug;58(2):206–213. [PubMed] [Google Scholar]
  2. Barton J. C., Conrad M. E., Parmley R. T. Acute lymphoblastic leukemia in idiopathic refractory sideroblastic anemia: evidence for a common lymphoid and myeloid progenitor cell. Am J Hematol. 1980;9(1):109–115. doi: 10.1002/ajh.2830090111. [DOI] [PubMed] [Google Scholar]
  3. Breton-Gorius J., Reyes F., Duhamel G., Najman A., Gorin N. C. Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase. Blood. 1978 Jan;51(1):45–60. [PubMed] [Google Scholar]
  4. Butler W. M., Taylor H. G., Viswanathan U. Idiopathic acquired sideroblastic anemia terminating in acute myelosclerosis. Cancer. 1982 Jun 15;49(12):2497–2499. doi: 10.1002/1097-0142(19820615)49:12<2497::aid-cncr2820491215>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  5. Castro-Malaspina H., Moore M. A. Pathophysiological mechanisms operating in the development of myelofibrosis: role of megakaryocytes. Nouv Rev Fr Hematol. 1982;24(4):221–226. [PubMed] [Google Scholar]
  6. Catovsky D., Shaw M. T., Hoffbrand A. V., Dacie J. V. Sideroblastic anaemia and its association with leukaemia and myelomatosis: a report of five cases. Br J Haematol. 1971 Apr;20(4):385–393. doi: 10.1111/j.1365-2141.1971.tb07050.x. [DOI] [PubMed] [Google Scholar]
  7. Cheng D. S., Kushner J. P., Wintrobe M. M. Idiopathic refractory sideroblastic anemia: incidence and risk factors for leukemic transformation. Cancer. 1979 Aug;44(2):724–731. doi: 10.1002/1097-0142(197908)44:2<724::aid-cncr2820440245>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  8. DAMESHEK W. SIDEROBLASTIC ANAEMIA: IS THIS A MALIGNANCY? Br J Haematol. 1965 Jan;11:52–58. doi: 10.1111/j.1365-2141.1965.tb00084.x. [DOI] [PubMed] [Google Scholar]
  9. Dameshek W. The DiGuglielmo syndrome revisited. Blood. 1969 Nov;34(5):567–572. [PubMed] [Google Scholar]
  10. Kushner J. P., Lee G. R., Wintrobe M. M., Cartwright G. E. Idiopathic refractory sideroblastic anemia: clinical and laboratory investigation of 17 patients and review of the literature. Medicine (Baltimore) 1971 May;50(3):139–159. doi: 10.1097/00005792-197105000-00001. [DOI] [PubMed] [Google Scholar]
  11. LEWIS S. M., SZUR L. MALIGNANT MYELOSCLEROSIS. Br Med J. 1963 Aug 24;2(5355):472–477. doi: 10.1136/bmj.2.5355.468-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lewy R. I., Kansu E., Gabuzda T. Leukemia in patients with acquired idiopathic sideroblastic anemia: an evaluation of prognostic indicators. Am J Hematol. 1979;6(4):323–331. doi: 10.1002/ajh.2830060404. [DOI] [PubMed] [Google Scholar]
  13. Lukowicz D. F., Myers T. J., Grasso J. A., Albala M. M. Sideroblastic anemia terminating in myelofibrosis. Am J Hematol. 1982 Nov;13(3):253–257. doi: 10.1002/ajh.2830130309. [DOI] [PubMed] [Google Scholar]
  14. McCulloch E. A. Haemopoiesis in myeloblastic leukaemia. Clin Haematol. 1979 Jun;8(2):501–523. [PubMed] [Google Scholar]
  15. Prchal J. T., Throckmorton D. W., Carroll A. J., 3rd, Fuson E. W., Gams R. A., Prchal J. F. A common progenitor for human myeloid and lymphoid cells. Nature. 1978 Aug 10;274(5671):590–591. doi: 10.1038/274590a0. [DOI] [PubMed] [Google Scholar]
  16. Yeung K., Trowbridge A. A. Idiopathic acquired sideroblastic anemia terminating in acute myelofibrosis: case report and review of leterature. Cancer. 1977 Jan;39(1):359–365. doi: 10.1002/1097-0142(197701)39:1<359::aid-cncr2820390155>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]

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