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. 1984 Oct;37(10):1144–1146. doi: 10.1136/jcp.37.10.1144

Parvovirus infection in a family associated with aplastic crisis in an affected sibling pair with hereditary spherocytosis.

D H Green, A J Bellingham, M J Anderson
PMCID: PMC498956  PMID: 6092438

Abstract

There have been many reports of aplastic crisis preceded by a febrile illness in hereditary haemolytic anaemias. Recent research has shown that the human parvovirus may be a causative agent. We report on an adult sibling pair with hereditary spherocytosis who presented in aplastic crisis after a febrile illness. Both had evidence of recent parvovirus infection, shown by the presence of IgM class specific antibody in their sera. The children of one of the sibling pair, one of whom has hereditary spherocytosis but no chronic haemolysis, showed similar evidence of acute parvovirus infection.

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Selected References

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  1. Ager E. A., Chin T. D., Poland J. D. Epidemic erythema infectiosum. N Engl J Med. 1966 Dec 15;275(24):1326–1331. doi: 10.1056/NEJM196612152752402. [DOI] [PubMed] [Google Scholar]
  2. Anderson M. J., Davis L. R., Hodgson J., Jones S. E., Murtaza L., Pattison J. R., Stroud C. E., White J. M. Occurrence of infection with a parvovirus-like agent in children with sickle cell anaemia during a two-year period. J Clin Pathol. 1982 Jul;35(7):744–749. doi: 10.1136/jcp.35.7.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anderson M. J., Davis L. R., Jones S. E., Pattison J. R., Serjeant G. R. The development and use of an antibody capture radioimmunoassay for specific IgM to a human parvovirus-like agent. J Hyg (Lond) 1982 Apr;88(2):309–324. doi: 10.1017/s0022172400070169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Anderson M. J., Jones S. E., Fisher-Hoch S. P., Lewis E., Hall S. M., Bartlett C. L., Cohen B. J., Mortimer P. P., Pereira M. S. Human parvovirus, the cause of erythema infectiosum (fifth disease)? Lancet. 1983 Jun 18;1(8338):1378–1378. doi: 10.1016/s0140-6736(83)92152-9. [DOI] [PubMed] [Google Scholar]
  5. Anderson M. J. The emerging story of a human parvovirus-like agent. J Hyg (Lond) 1982 Aug;89(1):1–8. doi: 10.1017/s0022172400070480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cohen B. J., Mortimer P. P., Pereira M. S. Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (SPLV). J Hyg (Lond) 1983 Aug;91(1):113–130. doi: 10.1017/s0022172400060095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cossart Y. E., Field A. M., Cant B., Widdows D. Parvovirus-like particles in human sera. Lancet. 1975 Jan 11;1(7898):72–73. doi: 10.1016/s0140-6736(75)91074-0. [DOI] [PubMed] [Google Scholar]
  8. Duncan J. R., Potter C. B., Cappellini M. D., Kurtz J. B., Anderson M. J., Weatherall D. J. Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency. Lancet. 1983 Jul 2;2(8340):14–16. doi: 10.1016/s0140-6736(83)90005-3. [DOI] [PubMed] [Google Scholar]
  9. Edwards J. M., Kessel I., Gardner S. D., Eaton B. R., Pollock T. M., Fleck D. G., Gibson P., Woodroof M., Porter A. D. A search for a characteristic illness in children with serological evidence of viral or toxoplasma infection. J Infect. 1981 Dec;3(4):316–323. doi: 10.1016/s0163-4453(81)91863-6. [DOI] [PubMed] [Google Scholar]
  10. Evans J. P., Rossiter M. A., Kumaran T. O., Marsh G. W., Mortimer P. P. Human parvovirus aplasia: case due to cross infection in a ward. Br Med J (Clin Res Ed) 1984 Mar 3;288(6418):681–681. doi: 10.1136/bmj.288.6418.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kelleher J. F., Luban N. L., Mortimer P. P., Kamimura T. Human serum "parvovirus": a specific cause of aplastic crisis in children with hereditary spherocytosis. J Pediatr. 1983 May;102(5):720–722. doi: 10.1016/s0022-3476(83)80243-1. [DOI] [PubMed] [Google Scholar]
  12. Mortimer P. P. Hypothesis: the aplastic crisis of hereditary spherocytosis is due to a single transmissible agent. J Clin Pathol. 1983 Apr;36(4):445–448. doi: 10.1136/jcp.36.4.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pattison J. R., Jones S. E., Hodgson J., Davis L. R., White J. M., Stroud C. E., Murtaza L. Parvovirus infections and hypoplastic crisis in sickle-cell anaemia. Lancet. 1981 Mar 21;1(8221):664–665. doi: 10.1016/s0140-6736(81)91579-8. [DOI] [PubMed] [Google Scholar]
  14. Paver W. K., Clarke S. K. Comparison of human fecal and serum parvo-like viruses. J Clin Microbiol. 1976 Jul;4(1):67–70. doi: 10.1128/jcm.4.1.67-70.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rao K. R., Patel A. R., Anderson M. J., Hodgson J., Jones S. E., Pattison J. R. Infection with parvovirus-like virus and aplastic crisis in chronic hemolytic anemia. Ann Intern Med. 1983 Jun;98(6):930–932. doi: 10.7326/0003-4819-98-6-930. [DOI] [PubMed] [Google Scholar]
  16. Serjeant G. R., Topley J. M., Mason K., Serjeant B. E., Pattison J. R., Jones S. E., Mohamed R. Outbreak of aplastic crises in sickle cell anaemia associated with parvovirus-like agent. Lancet. 1981 Sep 19;2(8247):595–597. doi: 10.1016/s0140-6736(81)92739-2. [DOI] [PubMed] [Google Scholar]
  17. Shneerson J. M., Mortimer P. P., Vandervelde E. M. Febrile illness due to a parvovirus. Br Med J. 1980 Jun 28;280(6231):1580–1580. doi: 10.1136/bmj.280.6231.1580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Summers J., Jones S. E., Anderson M. J. Characterization of the genome of the agent of erythrocyte aplasia permits its classification as a human parvovirus. J Gen Virol. 1983 Nov;64(Pt 11):2527–2532. doi: 10.1099/0022-1317-64-11-2527. [DOI] [PubMed] [Google Scholar]

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