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. 1985 Jan;38(1):49–53. doi: 10.1136/jcp.38.1.49

Argentaffin and argyrophil reactions and serotonin content of endocrine tumours.

C A Wells, S M Taylor, A C Cuello
PMCID: PMC499070  PMID: 2578484

Abstract

Sixty carcinoid tumours were tested in a retrospective study with an immunoperoxidase technique using a monoclonal antibody against serotonin immunoreactive sites, with argyrophil staining using the Grimelius technique, and with argentaffin staining using the Masson-Fontana technique. A good correlation between all three techniques in the diagnosis of ileal carcinoid tumour was found, but the immunoperoxidase technique showed greater sensitivity than the Masson-Fontana technique and greater specificity than the Grimelius technique in the diagnosis of foregut and hindgut carcinoid tumours. The immunoperoxidase technique with a monoclonal antibody against serotonin immunoreactive sites (YC5/45) is recommended as a sensitive and specific test for carcinoid tumours. The reactions in other endocrine tumours are also included.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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