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. 1985 Feb;38(2):146–159. doi: 10.1136/jcp.38.2.146

Heart transplant pathology: the British experience.

A Pomerance, P G Stovin
PMCID: PMC499095  PMID: 2981905

Abstract

An account of human heart transplantation as seen by the histopathologists involved at the two UK transplant centres is presented. Between January 1979 and July 1984 179 patients received 186 hearts and 124 are still alive up to four years after operation. Cyclosporin A based immunosuppression has been used in the last 120 patients. Four patients developed neoplastic lesions. The commonest reason for transplantation was ischaemic heart disease (63%), followed by congestive cardiomyopathy (35%). The seven retransplants were for acute or chronic rejection. The monitoring of rejection by endomyocardial biopsies is described, and the causes of death and necropsy findings are presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bieber C. P., Griepp R. B., Oyer P. E., David L. A., Stinson E. B. Relationship of rabbit ATG serum clearance rate to circulating T-cell level, rejection onset, and survival in cardiac transplantation. Transplant Proc. 1977 Mar;9(1):1031–1036. [PubMed] [Google Scholar]
  2. Bieber C. P., Stinson E. B., Shumway N. E., Payne R., Kosek J. Cardiac transplantation in man. VII. Cardiac allograft pathology. Circulation. 1970 May;41(5):753–772. doi: 10.1161/01.cir.41.5.753. [DOI] [PubMed] [Google Scholar]
  3. Billingham M. E. Some recent advances in cardiac pathology. Hum Pathol. 1979 Jul;10(4):367–386. doi: 10.1016/s0046-8177(79)80043-x. [DOI] [PubMed] [Google Scholar]
  4. Caves P. K., Stinson E. B., Billingham M. E., Rider A. K., Shumway N. E. Diagnosis of human cardiac allograft rejection by serial cardiac biopsy. J Thorac Cardiovasc Surg. 1973 Sep;66(3):461–466. [PubMed] [Google Scholar]
  5. Cebelin M. S., Hirsch C. S. Human stress cardiomyopathy. Myocardial lesions in victims of homicidal assaults without internal injuries. Hum Pathol. 1980 Mar;11(2):123–132. doi: 10.1016/s0046-8177(80)80129-8. [DOI] [PubMed] [Google Scholar]
  6. Cooper D. K., Charles R. G., Fraser R. C., Beck W., Barnard C. N. Long-term survival after orthotopic and heterotopic cardiac transplantation. Br Med J. 1980 Oct 25;281(6248):1093–1096. doi: 10.1136/bmj.281.6248.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cosimi A. B., Colvin R. B., Burton R. C., Rubin R. H., Goldstein G., Kung P. C., Hansen W. P., Delmonico F. L., Russell P. S. Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med. 1981 Aug 6;305(6):308–314. doi: 10.1056/NEJM198108063050603. [DOI] [PubMed] [Google Scholar]
  8. McGregor C. G., Fleck D. G., Nagington J., Stovin P. G., Cory-Pearce R., English T. A. Disseminated toxoplasmosis in cardiac transplantation. J Clin Pathol. 1984 Jan;37(1):74–77. doi: 10.1136/jcp.37.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McLeod A. A., Neil-Dwyer G., Meyer C. H., Richardson P. L., Cruickshank J., Bartlett J. Cardiac sequelae of acute head injury. Br Heart J. 1982 Mar;47(3):221–226. doi: 10.1136/hrt.47.3.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. O'Toole C. M., Carvalho G. S., Cranage M. P., Large S. Immune responses in cardiac transplantation. I. Detection of activated TIa+ cells in the blood during herpes virus infections. Clin Exp Immunol. 1984 Sep;57(3):671–678. [PMC free article] [PubMed] [Google Scholar]
  11. Spiegelhalter D. J., Stovin P. G. An analysis of repeated biopsies following cardiac transplantation. Stat Med. 1983 Jan-Mar;2(1):33–40. doi: 10.1002/sim.4780020105. [DOI] [PubMed] [Google Scholar]
  12. Starzl T. E., Nalesnik M. A., Porter K. A., Ho M., Iwatsuki S., Griffith B. P., Rosenthal J. T., Hakala T. R., Shaw B. W., Jr, Hardesty R. L. Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet. 1984 Mar 17;1(8377):583–587. doi: 10.1016/s0140-6736(84)90994-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Weintraub J., Warnke R. A. Lymphoma in cardiac allotransplant recipients. Clinical and histological features and immunological phenotype. Transplantation. 1982 Apr;33(4):347–351. doi: 10.1097/00007890-198204000-00002. [DOI] [PubMed] [Google Scholar]
  14. Williams D. M., Krick J. A., Remington J. S. Pulmonary infection in the compromised host: part I. Am Rev Respir Dis. 1976 Aug;114(2):359–394. doi: 10.1164/arrd.1976.114.2.359. [DOI] [PubMed] [Google Scholar]

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