Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1985 Feb;38(2):160–164. doi: 10.1136/jcp.38.2.160

Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

J M Theaker, K C Gatter, A Heryet, D J Evans, J O McGee
PMCID: PMC499096  PMID: 3968215

Abstract

In order to elucidate the origin of giant cells in giant cell myocarditis a case has been studied immunohistologically using monoclonal antibodies against a variety of antigens, including those associated with muscle and macrophages. The results strongly suggest that the giant cells are derived from macrophages rather than the muscle cells.

Full text

PDF
160

Images in this article

161Image
on p.161
162Image
on p.162
162Image
on p.162

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beverley P. C., Callard R. E. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol. 1981 Apr;11(4):329–334. doi: 10.1002/eji.1830110412. [DOI] [PubMed] [Google Scholar]
  2. Chambers T. J. Multinucleate giant cells. J Pathol. 1978 Nov;126(3):125–148. doi: 10.1002/path.1711260302. [DOI] [PubMed] [Google Scholar]
  3. Cordell J. L., Falini B., Erber W. N., Ghosh A. K., Abdulaziz Z., MacDonald S., Pulford K. A., Stein H., Mason D. Y. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984 Feb;32(2):219–229. doi: 10.1177/32.2.6198355. [DOI] [PubMed] [Google Scholar]
  4. Davies M. J., Pomerance A., Teare R. D. Idiopathic giant cell myocarditis--a distinctive clinico-pathological entity. Br Heart J. 1975 Feb;37(2):192–195. doi: 10.1136/hrt.37.2.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davies M. J. The cardiomyopathies: a review of terminology, pathology and pathogenesis. Histopathology. 1984 May;8(3):363–393. doi: 10.1111/j.1365-2559.1984.tb02351.x. [DOI] [PubMed] [Google Scholar]
  6. Debus E., Weber K., Osborn M. Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J. 1983;2(12):2305–2312. doi: 10.1002/j.1460-2075.1983.tb01738.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gerdes J., Schwab U., Lemke H., Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer. 1983 Jan 15;31(1):13–20. doi: 10.1002/ijc.2910310104. [DOI] [PubMed] [Google Scholar]
  8. Mason D. Y., Taylor C. R. The distribution of muramidase (lysozyme) in human tissues. J Clin Pathol. 1975 Feb;28(2):124–132. doi: 10.1136/jcp.28.2.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pyun K. S., Kim Y. H., Katzenstein R. E., Kikkawa Y. Giant cell myocarditis. Light and electron microscopic study. Arch Pathol. 1970 Aug;90(2):181–188. [PubMed] [Google Scholar]
  10. Tubbs R. R., Sheibani K., Hawk W. A. Giant cell myocarditis. Arch Pathol Lab Med. 1980 May;104(5):245–246. [PubMed] [Google Scholar]
  11. WHITEHEAD R. ISOLATED MYOCARDITIS. Br Heart J. 1965 Mar;27:220–230. doi: 10.1136/hrt.27.2.220. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES