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. 1985 Mar;38(3):259–264. doi: 10.1136/jcp.38.3.259

Incidence of intraglomerular platelets in steroid sensitive nephrotic syndrome.

J M Uttley, R A Elton, C M Hill, M K MacDonald
PMCID: PMC499121  PMID: 3973049

Abstract

Renal biopsies from 44 patients with steroid sensitive nephrotic syndrome were examined with respect to the content of their intraglomerular platelets and compared with 18 normal control patients and with 51 patients with membranous glomerulonephritis and the nephrotic syndrome. The results suggested that platelet activity was not involved in the pathogenesis of steroid sensitive nephrotic syndrome; in the active phase of the number of platelets in glomeruli is lower than that of normal controls, and this may be associated with increased sensitivity to aggregating agents as part of the nephrotic syndrome. After steroid treatment and disappearance of proteinuria, the number of intraglomerular platelets rises to normal values.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boulton Jones J. M., Tulloch I., Dore B., McLay A. Changes in the glomerular capillary wall induced by lymphocyte products and serum of nephrotic patients. Clin Nephrol. 1983 Aug;20(2):72–77. [PubMed] [Google Scholar]
  2. Duffy J. L., Cinque T., Grishman E., Churg J. Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. J Clin Invest. 1970 Feb;49(2):251–258. doi: 10.1172/JCI106234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FARQUHAR M. G., VERNIER R. L., GOOD R. A. Studies on familial nephrosis. II. Glomerular changes observed with the electron microscope. Am J Pathol. 1957 Jul-Aug;33(4):791–817. [PMC free article] [PubMed] [Google Scholar]
  4. Gerber M. A., Paronetto F. IgE in glomeruli of patients with nephrotic syndrome. Lancet. 1971 May 29;1(7709):1097–1099. doi: 10.1016/s0140-6736(71)91838-1. [DOI] [PubMed] [Google Scholar]
  5. Karpatkin S. Autoimmune thrombocytopenic purpura. Blood. 1980 Sep;56(3):329–343. [PubMed] [Google Scholar]
  6. Kauffmann R. H., Veltkamp J. J., Van Tilburg N. H., Van Es L. A. Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome. Am J Med. 1978 Oct;65(4):607–613. doi: 10.1016/0002-9343(78)90848-3. [DOI] [PubMed] [Google Scholar]
  7. Kendall A. G., Lohmann R. C., Dossetor J. B. Nephrotic syndrome. A hypercoagulable state. Arch Intern Med. 1971 Jun;127(6):1021–1027. [PubMed] [Google Scholar]
  8. Lagrue G., Xheneumont S., Branellec A., Hirbec G., Weil B. A vascular permeability factor elaborated from lymphocytes. I. Demonstration in patients with nephrotic syndrome. Biomedicine. 1975 Feb 10;23(1):37–40. [PubMed] [Google Scholar]
  9. Levinsky R. J., Malleson P. N., Barratt T. M., Soothill J. F. Circulating immune complexes in steroid-responsive nephrotic syndrome. N Engl J Med. 1978 Jan 19;298(3):126–129. doi: 10.1056/NEJM197801192980303. [DOI] [PubMed] [Google Scholar]
  10. Lewis E. J., Carpenter C. B., Schur P. H. Serum complement component levels in human glomerulonephritis. Ann Intern Med. 1971 Oct;75(4):555–560. doi: 10.7326/0003-4819-75-4-555. [DOI] [PubMed] [Google Scholar]
  11. Prasad D. R., Zimmerman S. W., Burkholder P. M. Immunohistologic features of minimal-change nephrotic syndrome. Arch Pathol Lab Med. 1977 Jul;101(7):345–349. [PubMed] [Google Scholar]
  12. Remuzzi G., Marchesi D., Mecca G., de Gaetano G., Silver M. Platelet hypersensitivity in the nephrotic syndrome. Proc Eur Dial Transplant Assoc. 1979;16:487–494. [PubMed] [Google Scholar]
  13. Richman A. V., Kasnic G., Jr Endothelial and platelet reactions in the idiopathic nephrotic syndrome: an ultrastructural study. Hum Pathol. 1982 Jun;13(6):548–553. doi: 10.1016/s0046-8177(82)80269-4. [DOI] [PubMed] [Google Scholar]
  14. Shalhoub R. J. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet. 1974 Sep 7;2(7880):556–560. doi: 10.1016/s0140-6736(74)91880-7. [DOI] [PubMed] [Google Scholar]
  15. Thomson P. D., Stokes C. R., Barratt T. M., Turner M. W., Soothill J. F. HLA antigens and atopic features in steroid-responsive nephrotic syndrome of childhood. Lancet. 1976 Oct 9;2(7989):765–768. doi: 10.1016/s0140-6736(76)90600-0. [DOI] [PubMed] [Google Scholar]

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