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. 1985 Mar;38(3):297–300. doi: 10.1136/jcp.38.3.297

Refractory anaemia terminating in a combined lymphoproliferative and myeloproliferative disorder.

L Camba, M V Joyner
PMCID: PMC499128  PMID: 3855867

Abstract

We report a case of non-sideroblastic refractory anaemia which evolved to a double lymphomyeloproliferative disorder. At presentation, bone marrow appearances and peripheral blood pancytopenia without myelomonocytosis were consistent with a diagnosis of non-sideroblastic refractory anaemia. Subsequently, the patient developed pronounced myelomonocytosis and lymphocytosis with prolymphocytes. Light and transmission electron microscopy as well as surface marker studies were compatible with a diagnosis of prolymphocytic transformation of chronic lymphocytic leukaemia/prolymphocytic leukaemia associated with myelomonocytic leukaemia. The pathogenesis of such double lympho-myeloproliferative disorders is discussed in the light of the evidence for common lymphoid and myeloid progenitor cells and some recent advances in the immunology of the myelodysplastic syndromes.

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Selected References

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  1. Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982 Jun;51(2):189–199. [PubMed] [Google Scholar]
  2. Catovsky D., Cherchi M., Brookss D., Bradely J., Zola H. Heterogeneity of B-cell leukemias demonstrated by the monoclonal antibody FMC7. Blood. 1981 Aug;58(2):406–408. [PubMed] [Google Scholar]
  3. Cazzola M., Barosi G., Berzuini C., Dacco M., Orlandi E., Stefanelli M., Ascari E. Quantitative evaluation of erythropoietic activity in dysmyelopoietic syndromes. Br J Haematol. 1982 Jan;50(1):55–62. doi: 10.1111/j.1365-2141.1982.tb01890.x. [DOI] [PubMed] [Google Scholar]
  4. Costello C., Catovsky D., O'Brien M., Galton D. A. Prolymphocytic leukaemia: an ultrastructural study of 22 cases. Br J Haematol. 1980 Mar;44(3):389–394. doi: 10.1111/j.1365-2141.1980.tb05908.x. [DOI] [PubMed] [Google Scholar]
  5. Enno A., Catovsky D., O'Brien M., Cherchi M., Kumaran T. O., Galton D. A. 'Prolymphocytoid' transformation of chronic lymphocytic leukaemia. Br J Haematol. 1979 Jan;41(1):9–18. doi: 10.1111/j.1365-2141.1979.tb03676.x. [DOI] [PubMed] [Google Scholar]
  6. Galton D. A., Goldman J. M., Wiltshaw E., Catovsky D., Henry K., Goldenberg G. J. Prolymphocytic leukaemia. Br J Haematol. 1974 May;27(1):7–23. doi: 10.1111/j.1365-2141.1974.tb06769.x. [DOI] [PubMed] [Google Scholar]
  7. Geschke W., Beutler E. Refractory sideroblastic and nonsideroblastic anemia: a review of 27 cases. West J Med. 1977 Aug;127(2):85–92. [PMC free article] [PubMed] [Google Scholar]
  8. HAYHOE F. G., QUAGLINO D. Cytochemical demonstration and measurement of leucocyte alkaline phosphatase activity in normal and pathological states by a modified azo-dye coupling technique. Br J Haematol. 1958 Oct;4(4):375–389. doi: 10.1111/j.1365-2141.1958.tb06039.x. [DOI] [PubMed] [Google Scholar]
  9. Kerndrup G., Meyer K., Ellegaard J., Hokland P. Natural killer (NK)-cell activity and antibody-dependent cellular cytotoxicity (ADCC) in primary preleukemic syndrome. Leuk Res. 1984;8(2):239–247. doi: 10.1016/0145-2126(84)90147-4. [DOI] [PubMed] [Google Scholar]
  10. Manoharan A., Catovsky D., Clein P., Traub N. E., Costello C., O'Brien M., Boralessa H., Galton D. A. Simultaneous or spontaneous occurrence of lympho- and myeloproliferative disorders: a report of four cases. Br J Haematol. 1981 May;48(1):111–116. doi: 10.1111/j.1365-2141.1981.00111.x. [DOI] [PubMed] [Google Scholar]
  11. Prchal J. T., Throckmorton D. W., Carroll A. J., 3rd, Fuson E. W., Gams R. A., Prchal J. F. A common progenitor for human myeloid and lymphoid cells. Nature. 1978 Aug 10;274(5671):590–591. doi: 10.1038/274590a0. [DOI] [PubMed] [Google Scholar]
  12. Quesenberry P., Levitt L. Hematopoietic stem cells. N Engl J Med. 1979 Oct 4;301(14):755–761. doi: 10.1056/NEJM197910043011404. [DOI] [PubMed] [Google Scholar]
  13. Roberts-Thomson I. C., Whittingham S., Youngchaiyud U., Mackay I. R. Ageing, immune response, and mortality. Lancet. 1974 Aug 17;2(7877):368–370. doi: 10.1016/s0140-6736(74)91755-3. [DOI] [PubMed] [Google Scholar]
  14. Rosenthal D. S., Moloney W. C. Refractory dysmyelopoietic anemia and acute leukemia. Blood. 1984 Feb;63(2):314–318. [PubMed] [Google Scholar]
  15. Schrader J. W. Role of a single haemopoietic growth factor in multiple proliferative disorders of haemopoietic and related cells. Lancet. 1984 Jul 21;2(8395):133–137. doi: 10.1016/s0140-6736(84)91049-3. [DOI] [PubMed] [Google Scholar]
  16. Zittoun R. Annotation: Subacute and chronic myelomonocytic leukaemia: a distinct haematological entity. Br J Haematol. 1976 Jan;32(1):1–7. doi: 10.1111/j.1365-2141.1976.tb01868.x. [DOI] [PubMed] [Google Scholar]
  17. Zittoun R., Bernadou A., Zittoun J., Cadiou M., Degos L. Leucémie myélo-monocytaire subaiguë. Etude cyto- et biochimique des lignées granulocytaires et monocytaires. Sem Hop. 1972 Jun 8;48(27):1965–1970. [PubMed] [Google Scholar]

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