Table 3. p-values and nature of the relationship between the capillaries and the INRG poor-prognostic factors.
| Parameter | Stage: metastatic | Age: >18 months | Histopathology: (pd, uNB) | MYCN: MNA | Genetic profile: SCA | 11q: 11qD | Risk group: high-risk |
|---|---|---|---|---|---|---|---|
| Density | - | - | 0.008↑ | - | - | - | - |
| SA | - | 0.040↓ | 0.028↑, *0.019↑ | 0.021↓ | - | - | - |
| Rel. density | - | - | - | 0.018↓ | - | - | - |
| Rel. SA | - | 0.039↓ | - | 0.032↓ | - | - | - |
| Area | - | - | 0.001↑ | 0.001↑ | - | - | 0.006↑ |
| Length | - | - | 0.010↑ | - | - | - | - |
| Width | - | - | 0.001↑ | 0.001↑ | - | - | 0.003↑ |
| Perimeter | - | - | 0.001↑ | - | - | - | - |
| Aspect | - | - | 0.001↓ | 0.000↓ | - | - | 0.001↓ |
| Roundness | - | - | 0.001↓ | 0.000↓ | - | - | 0.002↓ |
| Per. ratio | - | - | - | - | - | - | - |
| Deformity | - | 0.046↓ | 0.015↑ | - | - | - | - |
| Shape factor | 0.026↓ | - | 0.000↓ | 0.000↓ | - | - | 0.000↓ |
| Branching | - | - | 0.007↑ | - | - | - | - |
SA: Stained area Rel. density: relative density, Rel. SA: relative SA, Per. ratio: perimeter ratio, -: not statistically significant, ↑/↓: higher or lower median value for the poor-prognostic group(s)
*
statistically significant differences between the different degrees of differentiation within the NB histological category.