Figure 4. Proteomics analysis of stromal cell types.

Volcano plots summarising the analysis of differentially expressed proteins, comparing Normal vs Disease stroma A. normal vs exosome-stimulated normal stroma B. normal vs sTGFβ-stimulated normal stroma C., where coloured symbols represent individual patients (n=6) and WCB949v-depicts the inclusion of data where the protein dose through the workflow was 1, 2, 4 and 8 μg instead of 10ug for all other samples. The thresholds shown indicate a p value <0.01 and a fold change of ±1.5. Identifications outside these criteria were not considered as differentially expressed. A Venn diagram D. shows a comparison of the differentially expressed protein lists, and the specific identifications are highlighted in Table 2.