Figure 3. Several different aromatase inhibitors promote lymphoma growth in male NSG mice grafted with human mantle B cell lymphomas cells (Granta-519).

Intact male NSG mice were grafted with human Granta-519 Mantle cell lymphoma cells and treated with different aromatase inhibitors, Letrozole (▲) (n=8), Anastrazole (■) (n=9), Exemestane (▼) (n=9) or vehicle (●) (n=9) from the time of development of palpable tumors. Tumor growth curves are shown.* p<0.05, ** p<0.01, ***p<0.001 vehicle vs. Letrozole, # p<0.05, ## p<0.01 vehicle vs. Anastrazole, ¶ p<0.05 vehicle vs. Exemestane. No significant difference in lymphoma tumor growth was seen between any of the aromatase inhibitors. Data analyzed by 2-tailed Student t-test.