Figure 1. The expression of RUNX2 in human GC specimens is correlated with the outcome of GC patients.

(A) RUNX2 is not or only weakly expressed in normal gastric tissue as detected by IHC staining. (B and C) RUNX2 expression in GC tissues is correlated with different stages of differentiation and depth of tumor invasion. Arrows indicate RUNX2 positive GC cells. (D) Positive staining of RUNX2 in GC metastatic foci of lymph node. (E) Kaplan-Meier Overall survival curves indicate that patients with RUNX2^High staining have shorter life time after surgery than patients with RUNX2^Low tumors (RUNX2^High, n = 220 and RUNX2^Low, n = 85). Scale bar = 50 μm.