Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1985 May;38(5):481–488. doi: 10.1136/jcp.38.5.481

Immunocytochemistry of folliculo-stellate cells of normal and neoplastic human pituitary gland.

C S Morris, E Hitchcock
PMCID: PMC499193  PMID: 3889065

Abstract

Five normal human pituitaries and 20 pituitary neoplasms were investigated by immunocytochemical methods. Glial fibrillary acidic protein and S100 have been shown in the anterior lobe of the pituitary. Both these markers were present in the folliculo-stellate cell. Evidence is presented for the presence of a transitional folliculo-stellate cell which is immunoreactive for S100. The role of the folliculo-stellate cell is discussed.

Full text

PDF
481

Images in this article

482Image
on p.482
482Image
on p.482
483Image
on p.483
484Image
on p.484
485Image
on p.485
485Image
on p.485
486Image
on p.486
487Image
on p.487

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allan P. M., Garson J. A., Harper E. I., Asser U., Coakham H. B., Brownell B., Kemshead J. T. Biological characterization and clinical applications of a monoclonal antibody recognizing an antigen restricted to neuroectodermal tissues. Int J Cancer. 1983 May 15;31(5):591–598. doi: 10.1002/ijc.2910310510. [DOI] [PubMed] [Google Scholar]
  2. Asa S. L., Ryan N., Kovacs K., Singer W., Marangos P. J. Immunohistochemical localization of neuron-specific enolase in the human hypophysis and pituitary adenomas. Arch Pathol Lab Med. 1984 Jan;108(1):40–43. [PubMed] [Google Scholar]
  3. Bergland R. M., Torack R. M. An ultrastructural study of follicular cells in the human anterior pituitary. Am J Pathol. 1969 Nov;57(2):273–297. [PMC free article] [PubMed] [Google Scholar]
  4. Bonnin J. M., Rubinstein L. J. Immunohistochemistry of central nervous system tumors. Its contributions to neurosurgical diagnosis. J Neurosurg. 1984 Jun;60(6):1121–1133. doi: 10.3171/jns.1984.60.6.1121. [DOI] [PubMed] [Google Scholar]
  5. Cocchia D., Miani N. Immunocytochemical localization of the brain-specific S-100 protein in the pituitary gland of adult rat. J Neurocytol. 1980 Dec;9(6):771–782. doi: 10.1007/BF01205018. [DOI] [PubMed] [Google Scholar]
  6. Dhillon A. P., Rode J., Leathem A. Neurone specific enolase: an aid to the diagnosis of melanoma and neuroblastoma. Histopathology. 1982 Jan;6(1):81–92. doi: 10.1111/j.1365-2559.1982.tb02704.x. [DOI] [PubMed] [Google Scholar]
  7. Fukuda T. Agranular stellate cells (so-called follicular cells) in human fetal and adult adenohypophysis and in pituitary adenoma. Virchows Arch A Pathol Pathol Anat. 1973 Mar 20;359(1):19–30. doi: 10.1007/BF00549080. [DOI] [PubMed] [Google Scholar]
  8. Horvath E., Kovacs K., Penz G., Ezrin C. Origin, possible function and fate of "follicular cells" in the anterior lobe of the human pituitary. Am J Pathol. 1974 Nov;77(2):199–212. [PMC free article] [PubMed] [Google Scholar]
  9. Kahn H. J., Marks A., Thom H., Baumal R. Role of antibody to S100 protein in diagnostic pathology. Am J Clin Pathol. 1983 Mar;79(3):341–347. doi: 10.1093/ajcp/79.3.341. [DOI] [PubMed] [Google Scholar]
  10. Nakajima T., Yamaguchi H., Takahashi K. S100 protein in folliculostellate cells of the rat pituitary anterior lobe. Brain Res. 1980 Jun 9;191(2):523–531. doi: 10.1016/0006-8993(80)91300-1. [DOI] [PubMed] [Google Scholar]
  11. Odelstad L., Påhlman S., Läckgren G., Larsson E., Grotte G., Nilsson K. Neuron specific enolase: a marker for differential diagnosis of neuroblastoma and Wilms' tumor. J Pediatr Surg. 1982 Aug;17(4):381–385. doi: 10.1016/s0022-3468(82)80494-6. [DOI] [PubMed] [Google Scholar]
  12. Otsuka Y., Ishikawa H., Omoto T., Takasaki Y., Yoshimura F. Effect of CRF on the morphological and functional differentiation of the cultured chromophobes isolated from rat anterior pituitaries. Endocrinol Jpn. 1971 Apr;18(2):133–153. doi: 10.1507/endocrj1954.18.133. [DOI] [PubMed] [Google Scholar]
  13. Royds J. A., Parsons M. A., Taylor C. B., Timperley W. R. Enolase isoenzyme distribution in the human brain and its tumours. J Pathol. 1982 May;137(1):37–49. doi: 10.1002/path.1711370105. [DOI] [PubMed] [Google Scholar]
  14. Salm A. K., Hatton G. I., Nilaver G. Immunoreactive glial fibrillary acidic protein in pituicytes of the rat neurohypophysis. Brain Res. 1982 Mar 25;236(2):471–476. doi: 10.1016/0006-8993(82)90729-6. [DOI] [PubMed] [Google Scholar]
  15. Schmechel D., Marangos P. J., Brightman M. Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature. 1978 Dec 21;276(5690):834–836. doi: 10.1038/276834a0. [DOI] [PubMed] [Google Scholar]
  16. Shirasawa N., Kihara H., Yamaguchi S., Yoshimura F. Pituitary folliculo-stellate cells immunostained with S-100 protein antiserum in postnatal, castrated and thyroidectomized rats. Cell Tissue Res. 1983;231(2):235–249. doi: 10.1007/BF00222177. [DOI] [PubMed] [Google Scholar]
  17. Sternberger L. A., Hardy P. H., Jr, Cuculis J. J., Meyer H. G. The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem. 1970 May;18(5):315–333. doi: 10.1177/18.5.315. [DOI] [PubMed] [Google Scholar]
  18. Suess U., Pliska V. Identification of the pituicytes as astroglial cells by indirect immunofluorescence-staining for the glial fibrillary acidic protein. Brain Res. 1981 Sep 21;221(1):27–33. doi: 10.1016/0006-8993(81)91061-1. [DOI] [PubMed] [Google Scholar]
  19. Tapia F. J., Polak J. M., Barbosa A. J., Bloom S. R., Marangos P. J., Dermody C., Pearse A. G. Neuron-specific enolase is produced by neuroendocrine tumours. Lancet. 1981 Apr 11;1(8224):808–811. doi: 10.1016/s0140-6736(81)92682-9. [DOI] [PubMed] [Google Scholar]
  20. Velasco M. E., Roessmann U., Gambetti P. The presence of glial fibrillary acidic protein in the human pituitary gland. J Neuropathol Exp Neurol. 1982 Mar;41(2):150–163. doi: 10.1097/00005072-198203000-00005. [DOI] [PubMed] [Google Scholar]
  21. Vila-Porcile E. Le réseau des cellules folliculo-stellaires et les follicules de l'adénohypophyse du rat (pars distalis. Z Zellforsch Mikrosk Anat. 1972;129(3):328–369. [PubMed] [Google Scholar]
  22. Yoshimura F., Nogami H. Immunohistochemical characterization of pituitary stellate cells in rats. Endocrinol Jpn. 1980 Feb;27(1):43–51. doi: 10.1507/endocrj1954.27.43. [DOI] [PubMed] [Google Scholar]
  23. Yoshimura F., Soji T., Sato S., Yokoyama M. Development and differentiation of rat pituitary follicular cells under normal and some experimental conditions with special reference to an interpretation of renewal cell system. Endocrinol Jpn. 1977 Oct;24(5):435–449. doi: 10.1507/endocrj1954.24.435. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES