Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1985 May;38(5):489–495. doi: 10.1136/jcp.38.5.489

Quantitative morphometry of squamous cell hyperplasia of the larynx.

P Olde Kalter, H Lubsen, J F Delemarre, C L Alons, R W Veldhuizen, C J Meyer, G B Snow
PMCID: PMC499194  PMID: 3889066

Abstract

The histopathological diagnosis of squamous cell hyperplasia of the larynx is very subjective. Since morphometry is highly reproducible, this method was applied to routine processed slides of 45 such lesions to assess objectively the epithelial characteristics. In each case measurements of nuclei of 50 cells in the basal, intermediate, and superficial cell layers were carried out. The data were analysed statistically. The findings suggest that quantitative morphometry may be helpful for the histopathological classification of squamous cell hyperplasia of the laryngeal mucosa.

Full text

PDF

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Giarelli L., Silvestri F., Antonutto G., Stanta G. Observations of the pathologist on precancerous lesions of the larynx. Integrated with histological data and quantitative analysis of nuclear DNA content. Acta Otolaryngol Suppl. 1977;344:7–18. [PubMed] [Google Scholar]
  2. Greisen O. Deoxyribonucleic acid content in the laryngeal mucosa with special reference to polyploid cell nuclei. Acta Pathol Microbiol Scand A. 1975 Nov;83(6):704–708. doi: 10.1111/j.1699-0463.1975.tb01400.x. [DOI] [PubMed] [Google Scholar]
  3. Gröntoft O., Hellquist H., Olofsson J., Nordström G. The DNA content and nuclear size in normal, dysplastic and carcinomatous laryngeal epithelium. A spectrophotometric study. Acta Otolaryngol. 1978 Nov-Dec;86(5-6):473–479. doi: 10.3109/00016487809107528. [DOI] [PubMed] [Google Scholar]
  4. Hellquist H., Olofsson J., Gröntoft O. Carcinoma in situ and severe dysplasia of the vocal cords. A clinicopathological and photometric investigation. Acta Otolaryngol. 1981 Nov-Dec;92(5-6):543–555. doi: 10.3109/00016488109133294. [DOI] [PubMed] [Google Scholar]
  5. Klein-Szanto A. J., Bánóczy J., Schroeder H. E. Metaplastic conversion of the differentiation pattern in oral epithelia affected by leukoplakia simplex. A stereologic study. Pathol Eur. 1976;11(3):189–210. [PubMed] [Google Scholar]
  6. Meijer C. J., van der Loo E. M., van Vloten W. A., van der Velde E. A., Scheffer E., Cornelisse C. J. Early diagnosis of mycosis fungoides and Sézary's syndrome by morphometric analysis of lymphoid cells in the skin. Cancer. 1980 Jun 1;45(11):2864–2871. doi: 10.1002/1097-0142(19800601)45:11<2864::aid-cncr2820451124>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  7. Miller A. H. Premalignant laryngeal lesions, carcinoma in situ, superficial carcinoma--definition and management. Can J Otolaryngol. 1974;3(4):573–575. [PubMed] [Google Scholar]
  8. Weibel E. R. Stereological principles for morphometry in electron microscopic cytology. Int Rev Cytol. 1969;26:235–302. doi: 10.1016/s0074-7696(08)61637-x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES