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. 1985 May;38(5):496–501. doi: 10.1136/jcp.38.5.496

Morphometric analysis of nuclei in epithelial structures from normal and neoplastic endometrium: a study using the Isaacs cell sampler and Endoscann instruments.

E Skaarland
PMCID: PMC499196  PMID: 3889067

Abstract

Morphometric analysis of nuclear area and shape in epithelial cells from cytological specimens from 35 patients with normal endometrium and from 20 patients with moderately or well differentiated endometrial adenocarcinoma was performed. The mean nuclear area in malignant cells was significantly higher than in normal epithelial cells. The range of the mean values from the normal cases, however, included 70% of the malignant values. Furthermore, individual cell groups in a normal cell population often gave values well within the malignant range. The greatest distinction between normal and malignant cases was obtained using a cut off mean value of 45 micron 2. With this as the sole criterion 17% of reports would have been false positives and 25% false negatives.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbaro C. A., Fortune D. W., Bodey A. S., Hennessy E. Uterine lavage in the diagnosis of endometrial malignancy and its precursors. Acta Cytol. 1982 Mar-Apr;26(2):135–140. [PubMed] [Google Scholar]
  2. Ellice R. M., Morse A. R., Anderson M. C. Aspiration cytology versus histology in the assessment of the endometrium of women attending a menopause clinic. Br J Obstet Gynaecol. 1981 Apr;88(4):421–425. doi: 10.1111/j.1471-0528.1981.tb01007.x. [DOI] [PubMed] [Google Scholar]
  3. Favre J., Bernard P., Besançon D., Siebert S. A five-year experience with intrauterine washing cytology. Acta Cytol. 1982 Sep-Oct;26(5):623–629. [PubMed] [Google Scholar]
  4. Gravlee L. C., Jr Jet-irrigation method for the diagnosis of endometrial adenocarcinoma. Its principle and accuracy. Obstet Gynecol. 1969 Aug;34(2):168–172. [PubMed] [Google Scholar]
  5. Ng A. B. The cellular detection of endometrial carcinoma and its precursors. Gynecol Oncol. 1974 Aug;2(2-3):162–179. doi: 10.1016/0090-8258(74)90007-9. [DOI] [PubMed] [Google Scholar]
  6. Niklasson O., Johansson R., Stormby N. Screening of endometrial carcinoma by jet wash and endouterine aspiration cytology. Acta Obstet Gynecol Scand. 1981;60(2):125–129. [PubMed] [Google Scholar]
  7. Segadal E., Iversen O. E. Endoscann, a new endometrial cell sampler. Br J Obstet Gynaecol. 1983 Mar;90(3):266–271. doi: 10.1111/j.1471-0528.1983.tb08622.x. [DOI] [PubMed] [Google Scholar]
  8. Segadal E., Iversen O. E. The Isaacs cell sampler: an alternative to curettage. Br Med J. 1980 Aug 2;281(6236):364–365. doi: 10.1136/bmj.281.6236.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Segadal E., Iversen O. E., Ulstein M. Comparison of cytological 'jet-wash' specimens and histology in endometrial carcinoma. J Clin Pathol. 1980 Jul;33(7):688–690. doi: 10.1136/jcp.33.7.688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. So-Bosita J. L., Lebherz T. B., Blair O. M. Endometrial jet washer. Obstet Gynecol. 1970 Aug;36(2):287–293. [PubMed] [Google Scholar]
  11. Sturdee D. W., Wade-Evans T., Paterson M. E., Thom M., Studd J. W. Relations between bleeding pattern, endometrial histology, and oestrogen treatment in menopausal women. Br Med J. 1978 Jun 17;1(6127):1575–1577. doi: 10.1136/bmj.1.6127.1575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Underwood P. B., Jr, Kellett M. P., McKee E. E., Clark A. The Gravlee Jet Washer: can it replace the diagnostic curettage? Am J Obstet Gynecol. 1973 Sep 15;117(2):201–209. doi: 10.1016/0002-9378(73)90633-9. [DOI] [PubMed] [Google Scholar]

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