Skip to main content
PMC home page
Nature Communications logoLink to Nature Communications
. 2016 Aug 17;7:12223. doi: 10.1038/ncomms12223

General low-temperature reaction pathway from precursors to monomers before nucleation of compound semiconductor nanocrystals

Kui Yu 1,a, Xiangyang Liu 2, Ting Qi 3, Huaqing Yang 3,a, Dennis M Whitfield 2, Queena Y Chen 2, Erik J C Huisman 2, Changwei Hu 1
PMCID: PMC4992053  PMID: 27531507

Abstract

Little is known about the molecular pathway to monomers of semiconductor nanocrystals. Here we report a general reaction pathway, which is based on hydrogen-mediated ligand loss for the precursor conversion to ‘monomers' at low temperature before nucleation. We apply 31P nuclear magnetic resonance spectroscopy to monitor the key phosphorous-containing products that evolve from MXn+E=PPh2H+HY mixtures, where MXn, E=PPh2H, and HY are metal precursors, chalcogenide precursors, and additives, respectively. Surprisingly, the phosphorous-containing products detected can be categorized into two groups, Ph2P–Y and Ph2P(E)–Y. On the basis of our experimental and theoretical results, we propose two competing pathways to the formation of M2En monomers, each of which is accompanied by one of the two products. Our study unravels the pathway of precursor evolution into M2En monomers, the stoichiometry of which directly correlates with the atomic composition of the final compound nanocrystals.

Inline graphicLittle is known about the molecular pathway to monomers of semiconductor nanocrystals. Here, the authors report a general reaction pathway based on hydrogen-mediated ligand loss for the precursor conversion to ‘monomers' at low temperature prior to nucleation, via 31P NMR spectroscopic measurements.

Colloidal semiconductor nanocrystal (NC) quantum dots (QDs) with distinct properties and well-acknowledged potential in many applications such as light-emitting diodes1,2, lasing3,4, photovoltaics5,6 and bio-labelling/imaging7,8,9 have been the focus of intense research ranging from fundamental science to applied technologies. For the past two decades, there have been significant efforts made to advance NC syntheses10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38. Mainly, the wet-chemical synthesis of colloidal metal chalcogenide NCs depends on the use of metal salts such as cadmium oleate (Cd(OA)2 or Cd(OOCC17H33)2) and tri-n-octylphosphine chalcogenides (E=P(C8H17)3 or ETOP, E=S, Se, and Te), together with beneficial additives in 1-octadecene (ODE) including diphenylphosphines13,14,15,16,17,18,19, primary alkyl amines16,25,26,27,28,29,30,35,36, thiols22,29,30,31 and alcohols14,27,34.

A major advance in the NC synthesis occurred with the recognition that commercial tertiary phosphine TOP contains dioctylphosphine (HP(C8H17)2, a secondary phosphine) that acts as an active impurity facilitating NC nucleation/growth but leading to low synthetic reproducibility (because of its varying amount from batch to batch)13,14,15,23. It was first suggested15 and then experimentally demonstrated23 that the use of commercial diphenylphosphine (HP(C6H5)2 or HPPh2, a secondary phosphine) resulted in an equilibrium of SeTOP+HPPh2⇌TOP+Se=PPh2H. Meanwhile, high metal-to-Se and low Se-to-TOP feed ratios were found to shift the equilibrium to the right23, which remarkably improved the NC synthesis with high particle yield and synthetic reproducibility at low reaction temperatures17,18,19,21,22,38. E=PPh2H is much more reactive than ETOP15,23. The use of ETOP+HPPh2 leading to the E precursor of E=PPh2H instead of ETOP has been shown to be beneficial for the synthesis of NCs such as PbSe (refs 17, 18) and CdSeS (ref. 38), while the direct use of E=PPh2H (made from E+HPPh2) is preferable to the synthesis of NCs such as ZnSe (ref. 19), ZnSeS (ref. 21) and CuInS2 (ref. 22). With the large number of recipes developed, recent studies have demonstrated clearly that the control of precursor reactivity has a strong impact on the reproducibility, particle yield, and size and size distribution of the resulting NCs17,18,19,21,22,36,37,38. For example, the reactivity of thiourea precursors was shown to control the size, yield and batch-to-batch consistency of PbS NCs37.

Generally, the current state-of-the-art in NC synthesis is principally empirical, with little insight into the stepwise pathway by which monomers are generated. There exists ‘an induction period' before nucleation occurs, which was briefly addressed for CdSe from CdX2+SePR3 (X=carboxylate and R=alkane groups ref. 33). During the induction period, the consumption of SePR3 was visible, but NC absorbance did not appear. The consumption of SePR3 was claimed to accumulate ‘solutes' that may be composed of multiple monomer units; afterwards, nucleation took place. Accordingly, the formation of ‘monomers' from precursors takes place at the beginning of the ‘induction period'.

With the monomer in the form of Cd1Se1 instead of Cd2Se2, the pathway from precursors to Cd1Se1 monomers was recently documented for CdSe NCs in the presence of C18H35NH2 as one additive from the reaction of Cd(OA)2+SeTOP+HPPh2. The P-containing products Ph2P-OOCC17H33 (1a), Ph2P−PPh2 (1b), Ph2P-NHC18H35 (1c) and Ph2P(Se)–NHC18H35 (2c) were detected, and the equilibrium of 1c+Se=PPh2H⇌2c+HPPh2 was demonstrated25. Different NC systems are supposed to follow different reaction pathways to their monomers; for this seemingly obvious reason, we decided to investigate individual pathways from precursor evolution to monomers at low reaction temperatures in each of the reactions of MXn+nE=PPh2H+HY, where M=Cu (I), Cd (II), Zn (II), Ge (II), Pb (II) and In (III), E=S, Se and Te, and HY=RCOOH, HPPh2, RNH2, RSH and ROH. The anion X for the starting metal cations was chosen such that MXn is soluble under the reaction conditions and can often be a long-chain alkyl carboxylate or thiolate. This reaction system has proven to be practical for the synthesis of various NCs with high quality, enhanced reproducibility and yield17,18,19,21,22,38. However, the pathway from precursors to monomers of the reaction MXn+nE=PPh2H+HY is perplexing to study because of the inevitable presence of HX and HPPh2 (as explained by the below equations 1, 2, 3, 4, 5, 6).

Here, we present our study on the reaction pathway from precursors to M2En monomers for the reaction of MXn+nE=PPh2H+HY. Conclusively, various P-containing compounds are detected for the metal M=Cu (I), Cd (II), Zn (II), Ge (II), Pb (II) and In (III) in combination with the chalcogen E=S, Se and Te. Most importantly and surprisingly, we are able to categorize these P-containing compounds into two groups of Ph2P–Y (1) and Ph2P(E)–Y (2), which are summarized in Supplementary Table 1 and Supplementary Note 1 (with Y=–OOCC17H33 (a), –PPh2 (b), –NHC18H35 (c), –SC12H25 (d) and –OC12H25 (e)), together with the detailed information on their assignment that includes our calculation of 31P NMR chemical shifts and a summary of the experimental information available in the literature. Accordingly, we propose two competing pathways leading to M2En monomers as illustrated by equations 1 and 2 (with further explanation in equations 3, 4, 5, 6).

graphic file with name ncomms12223-m1.jpg
graphic file with name ncomms12223-m2.jpg

where M=cation Cu (I), Cd(II), Zn (II), Ge (II), Pb (II) and In (III), n=1, 2 and 3 of the oxidation state of monovalent, divalent and trivalent M, respectively, X=anion (such as carboxylate C17H33COO−), E=S, Se and Te, and additive HY=RCOOH (a), HPPh2 (b), RNH2 (c), RSH (d) and ROH (e). A monomer in the form of M2En is proposed, which leads to NC nucleation followed by growth. The H atoms involved in the first and second H-mediated ligand loss steps are denoted as H′ and H″, respectively. It is noteworthy that other secondary phosphines such as dicyclohexylphosphine (HPCy2) leads to precursor E=PCy2H to start with; the correlation between the reactivity of E=PR2H (such as with R=Ph or Cy) and the size of the resulting NCs will be the subject of another study. Our general stepwise pathway from precursor evolution to M2En monomers at low reaction temperatures should result in a much more in-depth fundamental understanding, which may advance the design and synthesis of colloidal semiconductor NCs and advance the realization of their potential.

Results

NMR study of various reaction systems

The reactions studied are presented in Fig. 1 for CdSe and Supplementary Figs 1–9 for M (II) Se, Fig. 2 for CdS and Supplementary Figs 10–13 for CdS and ZnS, and Fig. 3 for CdTe and Supplementary Figs 14–21 for GeTe. Figure 4 is for Cu2Se, In2Se3 and CuInSe2, and Supplementary Figs 22–23 are for Cu2S, In2S3 and CuInS2. Figure 5 deals with [Cd(Se2PPh2)]2 (3)+Cd(OA)2+HY for the demonstration of equation 2, which leads to Cd2Se2+2 as shown by Supplementary Fig. 25 and which is supported by Supplementary Fig. 24 with the reaction of [Cd(Se2PPh2)]2 (3)+Cd(OA)2+HY+HPPh2. On the basis of our in situ31P NMR monitoring of a large number of reactions dealing with six metal cations (M) and three chalcogens (E) in the presence of the five types of HY additives, we propose a conceptual pathway (Fig. 6) that demonstrates the probable reactions from precursors to monomers. This distinct pathway starts with the coordination of n E=PPh2H molecules per MXn, followed by the H-mediated ligand loss of n HX molecules to result in one M(EPPh2)n (A). Afterwards, A undergoes dimerization to D that reacts with HY to E and/or F, or reacts with HY leading to B and/or C that undergoes dimerization to E and/or F, respectively. M2En and 1 are then produced from E (equation 1), while M2En and 2 from F (equation 2). Metathesis equilibria are involved, in which there are reversible exchanges of small ligand molecules, HPPh2, E=HPPh2 and HY (around metal chalcogenide centres, such as D+HY⇌E+E=PPh2H and D+HY⇌F+HPPh2), and chalcogenide exchange reactions such as 1+Se=PPh2H⇌2+HPPh2, which affect the detection of 1, 2 and HPPh2. The chalcogenide exchange equilibria were examined by density functional theory (DFT) shown in Supplementary Table 2 and Supplementary Note 2. Furthermore, we performed extensive DFT calculations for the probable isomers of the intermediates A–F shown in Fig. 6; therefore, we are able to elucidate further the pathway we proposed in Fig. 7, in which the probable isomers with detailed bonding skeletons of each intermediate A–F are illustrated, providing a much deeper understanding.

Figure 1. 31P NMR spectra of CdSe reaction mixtures with Se precursor.

Figure 1

Open in a new tab

(a) 2Cd(OOCC17H33)2+SeTOP+HPPh2. (b) 2Cd(OOCC17H33)2+SeTOP+HPPh2+2C18H35NH2. (c) 2Cd(OOCC17H33)2+SeTOP+HPPh2+2C12H25SH. (d) 2Cd(OOCC17H33)2+SeTOP+HPPh2+2C12H25OH. The experiments were performed at RT for 15 (1), 30 (2) and 60 min (3). The peak denoted with an asterisk (*) is TOP complexed to Cd (ref. 23). Interestingly, the P-containing products detected from the four reactions can be grouped into two product types, Ph2P–Y (1) and Ph2P(Se)–Y (2). The slowest disappearance of SeTOP is with the use of amine, the trend of which is in agreement with our kinetics study (Supplementary Figs 28–31 and Supplementary Note 5) based on our putative pathway proposed (Fig. 6) and the consideration of constitutional isomers (Fig. 7).

Figure 2. 31P NMR spectra of CdS reaction mixtures with S precursor.

Figure 2

Open in a new tab

(a) 2Cd(OOCC17H33)2+S=PPh2H. (b) 2Cd(OOCC17H33)2+S=PPh2H+4C18H35NH2. (c) 2Cd(OOCC17H33)2+S=PPh2H+4C12H25SH. The 1d−to−S=PPh2H ratio increased from 0.28 (1), 0.36 (2) to 0.41 (3) is shown in Supplementary Fig. 2c. (d) 2Cd(OOCC17H33)2+S=PPh2H+4C12H25OH. The experiments were carried out at RT for 15 (1), 30 (2) and 60 min (3). The peak denoted with an asterisk (*) is probably Cd(S2PPh2)2 (ref. 36).

Figure 3. 31P NMR spectra of CdTe reaction mixtures with Te precursor.

Figure 3

Open in a new tab

(a) 2Cd(OOCC17H33)2+TeTOP+HPPh2. (b) 2Cd(OOCC17H33)2+TeTOP+HPPh2+2C18H35NH2. (c) 2Cd(OOCC17H33)2+TeTOP+HPPh2+2C12H25SH. (d) 2Cd(OOCC17H33)2+TeTOP+HPPh2+2C12H25OH. The experiments were performed at RT for 15 (1), 30 (2), 45 (3) and 60 min (4) for a, and 15 (1), 30 (2) and 60 min (3) for the rest. The peak denoted with an asterisk (*) is TOP complexed to Cd (ref. 23).

Figure 4. 31P NMR spectra of Cu/In-containing reaction mixtures.

Figure 4

Open in a new tab

(a) CuI/C12H25SH+2Se=PPh2H, with RT (1), 80 °C per 10 min (2) and 100 °C per 10 min (3). (b) CuI/C12H25SH+2Se=PPh2H+8C18H35NH2, with RT per 10 min (1), 100 °C per 15 min (2) and 100 °C per 75 min (3). (c) CuI/C12H25SH+2Se=PPh2H+8C12H25OH, with RT (1), 80 °C per 10 min (2), 100 °C per 10 min (3). (d,e) In(OAc)3/C12H25SH+2Se=PPh2H, with RT per 15 min (1), 80 °C per 10 min (2), 100 °C per 10 min (3) for d and RT per 15 min (1) for e (repeated with 512 scans). (f) CuI/C12H25SH+In(OAc)3/C12H25SH+4Se=PPh2H, with RT per 15 min (1), 80 °C per 5 min (2) and 100 °C per 5 min (3). The peak denoted with an asterisk (*) was assigned to HPPh2 complexed to Cu (ref. 22).

Figure 5. 31P NMR spectra of reaction mixtures of 3+6Cd(OA)2+HY.

Figure 5

Open in a new tab

(a) 16RNH2. (b) 4RSH. (c) 16ROH. The slowest disappearance of 3 occurs with the use of amine, the trend of which is in agreement with that shown in Fig. 1. The relevant pathway to the formation of monomers and 2 is shown in Supplementary Fig. 25.

Figure 6. Schematic of the general pathway for formation of M2En monomers.

Figure 6

Open in a new tab

For simplicity, this figure is drawn for M (II) only at low temperature from metal carboxylate (MX2) and dialkylphosphine chalcogenide (E=PPh2H) with the use of additive HY. Specific schemes for the other metal valences can be constructed accordingly. E=S, Se or Te. When HY=RCOOH (a), HPPh2 (b), RNH2 (c), RSH (d) and ROH (e), Compounds 1 and 2 are labelled as 1a–e and 2a–e, respectively. The equilibrium of 1+E=PPh2H⇌2+HPPh2 is worthy of notice (Supplementary Table 2 and Supplementary Note 2). Note that another secondary phosphine, dicyclohexylphosphine (HPCy2), was also tested (as shown in Supplementary Figs 1 and 3); precursor E=PCy2H instead of E=PPh2H also leads to Compound Cy2P–Y (1) and Cy2P(E)–Y (2). The correlation between the reactivity of E=PR2H (with R=Ph or Cy) and the size of resulting NCs is the subject of another study. The dotted box is for a system to start from single-source precursors (such as 3 shown in Supplementary Fig. 25 with E=Se and M=Cd (II)). See Supplementary Fig. 26 and Supplementary Note 3 for the difference of the putative mechanisms proposed by ref. 15 and by the present study. With Y=PPh2, intermediate D in nature is F. Here two competing pathways are proposed for the formation of M2En monomer: one is A–(B or D)–E–1+M2En, the other is A−(C or D)–F–2+M2En.

Figure 7. Possible isomers with binding skeletons.

Figure 7

Open in a new tab

Here two of the most probable constitutional isomers of intermediates B to F are shown; there are 99 CdSe-containing isomer structures computed as shown Supplementary Tables 4–17. With M=Cd and E=Se, B1 and C1 are favoured for Y=NHR, whereas B2 and C2 are preferred for Y=SR, OOCR. For Y=OR, the distinction is not clear cut. For the immediate precursors E and F leading to monomers Cd2Se2 with Compounds 1 and 2, respectively, E1 and F1 are favoured for Y=NHR and OR, whereas E2 and F2 are preferred for Y=SR and OOCR. For Y=PPh2, D2 is more stable than D1. Possibly, the release of Compound 1 is more apparent from E1 (via the M–P bond cleavage) than from E2, while Compound 2 from F1 (via the M–E bond cleavage) than from F2.

Figure 1 presents our 31P NMR spectra collected from four representative mixtures of Cd(OA)2+SeTOP+HPPh2 (a) and with the additional additives of oleylamine (C18H35NH2, b), dodecylthiol (C12H25SH, c) and dodecylalcohol (C12H25OH, d). It is Se=PPh2H rather than SeTOP that reacts with Cd(OA)2 because of SeTOP+HPPh2⇌Se=PPh2H+TOP (refs 15, 23). The products 1a (Ph2P–OOCC17H35) and 1b (Ph2P–PPh2) equilibrate via Ph2P–COOR (1a)+HPPh2⇌RCOOH+Ph2P–PPh2 (1b), which is weighted to the right at room temperature (RT)21,24. The additional products of 2a (Ph2P(Se)–OOCC17H35) and 2b (Ph2P(Se)–PPh2) from the mixtures of Cd(OA)2, Zn(OA)2 or Ge(OA)2+Se=PPh2H are shown in Supplementary Figs 3–5. The addition of a primary amine C18H35NH2 to the mixture of Fig. 1a, as shown in Fig. 1b, resulted in additional 1c (Ph2P–NHC18H35) and 2c (Ph2P(Se)–NHC18H35). The use of the thiol C12H25SH generated 1d (Ph2P–SC12H25) without the detection of 1a and 1b (Fig. 1c). Similarly, the use of the alcohol C12H25OH produced 1e (Ph2P–OC12H25) and 2e (Ph2P(Se)–OC12H25; Fig. 1d). The same P-containing compounds were observed from the mixtures with Pb(OA)2 replacing Cd(OA)2 (Supplementary Fig. 5), which strongly suggests that Compounds 1a–e (Ph2P–Y) have their own similar pathways (for different Y), and Compounds 2a–e (Ph2P(Se)–Y) have their own similar pathways (for different Y). Thus, we propose that Compounds 1 and 2 follow two different paths for their formation from their own immediate precursors (Figs 1 and 2).

The temporal evolution of the absorption of growing CdSe NCs (shown in Supplementary Figs 6–7) suggests that the amount of additives, thiol C12H25SH or alcohol C12H25OH affects nucleation/growth, in addition to other experimental parameters such as the temperature and amount of HPPh2 used. Focusing on the identification of the reaction pathway before nucleation, the present study does not address the control of the size and size distribution, which could be affected by various experimental parameters including cation-to-anion feed molar ratios and the nature of Se=PR2H as shown by Supplementary Figs 8 and 9. In addition, the size and size distribution of the CdSe NCs synthesized with SeTOP+HPR2 (dicyclohexylphosphine (or HPCy2) and HPPh2) are different from those with Se=PCy2H and Se=PPh2H. Previously, the reaction of Cd(OA)2+Se=PCy2H was reported to lead to Compound Cy2P–OOCC17H33 (1a analogue) and Cy2P(Se)–OOCC17H33 (2a analogue)24. Therefore, the present study on the general reaction pathway from precursors to M2En monomers before nucleation at low reaction temperatures should benefit the field by leading to a better understanding of the ‘induction periods' to tailor, optimize and manipulate nucleation/growth, which offers finer control of the size and size distribution of NCs produced.

Figure 2 shows our 31P NMR spectra collected from four representative mixtures of Cd(OA)2+S=PPh2H (a) and with the additional additives of oleylamine (C18H35NH2, b), dodecylthiol (C12H25SH, c) and dodecylalcohol (C12H25OH, d). The chalcogenide S is generally less reactive than Se and Te under QD formation conditions10,11,12. Rather than employing an in situ generation of Se=PPh2H (Fig. 1 and Supplementary Figs 1–9) or Te=PPh2H (Fig. 3 and Supplementary Figs 14–21), the analogue S=PPh2H is sufficiently stable to be used directly (Supplementary Figs 10–13)21,22. The P-containing products detected from the S=PPh2H-related reactions with Cd(OA)2 (without additional HPPh2 but with free HPPh2 present) are similar to other chalcogenide-related reactions (Figs 1 and 3). Again, the products from the four reactions (Fig. 2) are grouped into Compounds 1 and 2. For example, the products formed are elucidated as follows: 1a without an additive (Fig. 2a), 1a and 1c with an amine additive (Fig. 2b), 1d with a thiol additive (Fig. 2c) and 1e and 1a with an alcohol additive (Fig. 2d). The major difference between the Cd+S reactions (Fig. 2) and the Cd+Se reactions (Fig. 1) is the formation of 2b′ (Ph2P(S)–PPh2) under all conditions. Compound 2b′ was also detected from a mixture of Zn(OA)2+S=PPh2H shown in Supplementary Figs 10–12.

TeTOP is much more reactive than SeTOP and STOP in QD engineering10,11,12. Under the reaction conditions, this fact is readily discernible, as TeTOP (Supplementary Fig. 14) reacts completely when the first spectrum (1) of the each reaction shown in Fig. 3 was collected. Again, the products 1a (Fig. 3a), 1c (together with 1a, in the presence of amine Fig. 3b), 1d (in the presence of thiol Fig. 3c) and 1e (in the presence of alcohol Fig. 3d) were detected in addition to 1b. The same P-containing products were detected from the Ge(OA)2+TeTOP+HPPh2+HY reactions (Supplementary Fig. 19). As shown in Supplementary Figs 15–17, the amount of HPPh2 used affects the ratio of 1a and 1b detected in the mixture of Cd(OA)2+TeTOP+HPPh2: the more HPPh2 is used, the more diphosphine compound 1b is detected, the trend of which is similar to what was reported for CdSe because of the equilibrium of Ph2P−COOR (1a)+HPPh2⇌RCOOH+Ph2P−PPh2 (1b) being weighted towards the right at RT21,24. Notably under these conditions, no Compound 2 (Ph2P(Te)–Y) was observed. The Te–P bond strength is lower than that of Se–P or S–P and, thus, Ph2P(Te)–Y might be too reactive to be detected.

For the S, Se and Te chalcogenide series with Cd (II) under all examined conditions (Figs 1, 2, 3), Ph2P–Y (1a–e) and/or Ph2P(E)–Y (2a–e) are identified as major P-containing products. For the other divalent metal salts of Zn, Ge and Pb studied, the same trends were discovered (Supplementary Figs 1–21). For E=Se (Supplementary Figs 1–2) in the absence of additional additives, 1a and 1b were predominantly found. With amine addition, 1c and 2c are also formed. With thiol addition, 1d is formed as a main product, and with alcohol addition, both 1e and 2e are formed. For E=S, 1a–e were detected along with 2b′ (Supplementary Figs 10–13). For E=Te, none of Ph2P(Te)–Y but 1a–e were observed (Supplementary Figs 14–21). Thus, for all the combinations investigated, the reaction of MX2+E=PPh2H+HY appeared to follow equation 1 to produce 1 and/or equation 2 to produce 2 along with the formation of M2E2 monomers.

More interestingly, the detection of P-containing compounds for Cu (I) and In (III) is similar to that for M (II). C12H25SH has been used as a solvent and a ligand to improve the synthesis of CuInSe2 and CuInS2 QDs22,29,30,31. Representative 31P NMR data for the synthesis of Cu2Se, In2Se3 and CuInSe2 using Se=PPh2H and S=PPh2H as the Se and S precursors are shown in Fig. 4, and for the synthesis of Cu2S, In2S3 and CuInS2 in Supplementary Figs 22 and 23. In the presence of CuI, C12H25SH and Se=PPh2H (Fig. 4a), 2d (Ph2P(Se)–SC12H25) is formed as Se=PPh2H is consumed. The absence of 1d (Ph2P–SC12H25) could be because of the equilibrium of 1d+Se=PPh2H⇌2d+HPPh2 being weighted towards the right (Supplementary Fig. 1, Supplementary Table 2 and Supplementary Note 2). As mentioned before, 1d and 2d should have their own formation path. The addition of amine (Fig. 4b) leads to the product 2c (Ph2P(Se)–NHC18H35), in addition to 1d and salt Ph2P(Se2)NH2C18H35 (which can have resulted from the reaction of Se=PPh2H+C18H35NH2)16,24,25. The addition of alcohol (Fig. 4c) results in 2e (Ph2P(Se)–OC12H25), in addition to 2d. The absence of 1e (Ph2P–OC12H25) could be because of the equilibrium of 1e+Se=PPh2H⇌2e+HPPh2 being weighted towards the right (Supplementary Fig. 2, Supplementary Table 2 and Supplementary Note 2).

Indium, as expected, is more reactive under the same reaction conditions where Se=PPh2H completely reacts at 80 °C per 10 min (Figs 4d–2) compared with Fig. 4a22. Intriguingly, at RT per 15 min (Fig. 4e with expansion), the additional peaks near free Se=PPh2H (∼7.3 p.p.m.) are readily interpreted as coordinated Se=PPh2H to In (Fig. 4e and Supplementary Fig. 22). The products 1d and 2d are observed with the absence of Se=PPh2H (Fig. 4d, the In-only experiment), whereas only 2d is formed in the reaction with the presence of Se=PPh2H (Fig. 4f with both the presence of Cu and In). Thus, the observation of Compounds 1 and 2 could be affected by several factors, including the equilibrium of 1+Se=PPh2H⇌2+HPPh2, which could be weighted towards the right (Supplementary Table 2 and Supplementary Note 2), similar to TOP+Se=PPh2H⇌SeTOP+HPPh2 (refs 15, 23), except for 1b+Se=PPh2H⇌2b+HPPh2 (refs 21, 23, 24, 25).

It is critical to perform additional experimental investigation regarding the formation of Compound 2 from a direct path. Figure 5 shows the corroborative evidence for equation 2 (Figs 6 and 7 and Supplementary Figs 1–9). These experiments relied on the independent preparation of cadmium bis(diselenophosphinate) (Cd(Se2PPh2)2, 3)24, which reacted with Cd(OA)2 in the presence of HY of C18H35NH2 (a), C12H25SH (b) and C12H25OH (c). The reaction of 3+Cd(OA)2+HY leads to 2c, 2d and 2e, respectively. It is noteworthy that 1 was not detected. The addition of oleic acid did not lead to 2a (not shown). These results suggest that equation 2 is active at the appropriate temperatures tested (with the amine, thiol and alcohol, but not with the acid). According to the previous study on 3+Cd(OA)2 (ref. 24), it is reasonable that the presence of HPPh2 could speed up equation 2. As shown by Supplementary Fig. 24, the catalytic amount of HPPh2 (0.05 eq. based on 3) accelerated significantly each of the three reactions, with 2 still being the main product. With more HPPh2 (1.00 eq. based on 3), additional 1c (with 1b), 1d (with 1a and 2a) and 1e were detected, respectively. Thus, HPPh2 could also initiate another equation 1 to 1+Cd2Se2 (via A (Cd(SePPh2)2) as shown in Supplementary Fig. 25). The results shown by Fig. 5 and Supplementary Fig. 24 clearly support that the equilibrium of 1e+Se=PPh2H⇌2e+HPPh2 is weighted towards the right, which is in agreement with our DFT examination shown in Supplementary Table 2 and Supplementary Note 2.

Figure 6 presents a schematic interpretation of our experimental results (shown in Figs 1, 2, 3, 4, 5 and Supplementary Figs 1–24). When a mixture of metal carboxylate and chalcogenide TOP compound (ETOP) was mixed with dialkylphosphine such as HPPh2 with or without the presence of additives such as amines, thiols and/or alcohols, the formation of NCs begins with chalcogen E exchange, namely ETOP+HPPh2⇌TOP+E=PPh2H (refs 15, 23, 24, 25), the exchange of which activates the chalcogenide. Subsequently, the activated E=PPh2H reacts by coordinating the chalcogenide atom to the metal centre (equation 3). In the absence of HPPh2, the dioctylphosphine impurity in TOP could play the same chemical function, which was only realized recently15,17,18,19,20,21,22,23.

graphic file with name ncomms12223-m3.jpg
graphic file with name ncomms12223-m4.jpg
graphic file with name ncomms12223-m5.jpg
graphic file with name ncomms12223-m6.jpg

Following the coordination (equation 3), as experimentally demonstrated by Fig. 4e, intermediate A (M–(EPPh2)n) is formed, accompanied by H−X (equation 4). It seems reasonable that the H–P bond of E=PPh2H is strong enough to sustain the coordination to the metal, but weak enough for H to leave and to form HX. The chalcogen coordination to the metal not only increases the acidity of the P-bound H but also makes H accessible to the adjacent X group. Thus, in the forward reaction direction, the P-bound H leads to the elimination of the ligand X resulting in A and HX (equation 4). In the next step, we propose A reacts with HY first to give B and/or C, which then dimerize towards E and/or F, respectively. At the same time, A could first dimerize towards D, [M−(EPPh2)n]2, and then reacts with HY to give E and/or F. For example, dimer D reacts with HY to produce E=PPh2H+M2En+Ph2P−Y (1; equation 5) or HPPh2+M2En+Ph2P(E)−Y (2; equation 6). Our proposed pathway leading to the observation of 1 and 2 significantly differs from the pathway proposed in 2010 (ref. 15), as detailed in Supplementary Fig. 26 and Supplementary Note 3. One major difference is intermediate A and its formation and subsequent evolution (equations 3, 4, 5, 6), which were not addressed in the work of 2010 but are clearly elucidated in the present study. Note that the pathway proposed in 2010 does not address at all the detection of 1b (PPh2−PPh2, 14 p.p.m.) from the reactions of Pb(OA)2+Se=PPh2H and Cd(OA)2+Se=PPh2H at RT.

Figure 6 is formulated for the case of M (II), but also applies to M (I) and M (III) where their monomers are accordingly proposed to be M2E and M2E3, respectively. Obviously, A and B are connected by equilibrium A+HY⇌B+E=PPh2H, while A and C by A+HY⇌C+HPPh2. Consequently, B and C are correlated by B+E=PPh2H⇌C+HPPh2, similarly to Compounds 1 and 2 by 1+E=PPh2H⇌2+HPPh2. These equilibria are clearly affected by the relative amount of HPPh2, E=PPh2H and HY. The formation of the monomer M2E2 occurs via the ligand loss of 1 from intermediate E (equation 1) and/or 2 from intermediate F (equation 2). With Y=PPh2, intermediate D in nature is F; thus, D can result in 2b+M2En (equation 2).

DFT study

To further understand the fundamental chemistry involved in the putative pathway proposed in Fig. 6, let us turn our attention to the possible isomers with their bonding skeletons of each of the intermediate species A to F proposed in Fig. 6. In addition to metal ions (M), chalcogenides (E) and diphenylphosphinio species (Ph2P), intermediates B to F contain the various Y groups. Consequently, each intermediate has multiple possible constitutional isomers, while most possible combinations of bonds, such as P–E, E–E, P–P, P–Y and E–Y bonds, exist in well-known compounds, and all such bonds can in principle coordinate to metal ions leading to multiple possibilities. For example, for Y=NHR in Fig. 6, the N could bond to Cd, P or Se; if N is bound to P, two bonding arrangements (M–P–N and M–N–P) could in principle be expected. These uncertainties are amenable to DFT calculations, which provide useful information to minimize positional isomers, with the cancellation of errors in the DFT approximation39,40,41,42. In this way, the calculated bonding trends should be reliable. The possibilities in Fig. 7 are distinguished by DFT calculations at the M06//B3LYP/6-31++G (d, p), Stuttgart/Dresden (SDD) level in ODE media. Our DFT-calculated structures and energies of many more possible isomers are shown in Supplementary Tables 3–25 including structural, geometric and rotational isomers. An additional description and discussion of the isomers of each intermediate A to F can be found immediately before Supplementary Tables 3–17.

The most stable A is with the P–Se–Cd–Se–P skeleton among the seven isomers computed (Supplementary Table 3). For the two predominant species B1 and B2 found, they have the Se–Cd–P–Y and P–Se–Cd–Y skeletons, respectively. B1 versus B2 includes P–Y versus M–Y bonds, without E–Y bonds. With Y=NHR for CdSe (Supplementary Table 4), the B1 isomer was calculated to be 10.1 kJ mol−1 (free energy ΔG) more stable than B2. This energy trend of B1<B2 was not found for the other Y. For Y=SR (Supplementary Table 4), the distinction is quite clear that the direct metal-bound B2 isomer P–Se–Cd–SR was calculated to be 82.5 kJ mol−1 more stable than the B1 isomer with Se–Cd–P–SR. For Y=OR (Supplementary Table 5), the B2 isomer with the P–Se–Cd–OR skeleton was found to be at the lowest energy, but the B1 isomer with the Se–Cd–P–OR skeleton was only 6.9 kJ mol−1 higher—an energy difference that is close to the accuracy of the DFT method and could be affected by the exact nature of various R groups, the solvent used and the temperature employed. For Y=OOCR (Supplementary Table 6), the directly metal-bound B2 isomer is 111.3 kJ mol−1 more stable than the B1 isomer with Se–Cd–P–OOCR. For Y=PPh2 (Supplementary Table 6), B2 is 58.7 kJ mol−1 more stable than B1.

Intermediate C with an extra chalcogen E atom compared with intermediate B evidently has more constitutional possibilities. Intriguingly, the connectivity follows similar patterns to that of intermediate B. For Y=NHR (Supplementary Table 7), C1 with the Se–Cd–Se–P–N connectivity has the lowest energy. Note that there is an extra Se inserted between the Cd and P atoms. The most stable Cd–N-bound species C2 was found to contain the four-membered N–Cd*–Se–P–Se–(Cd*) ring, which was 18.7 kJ mol−1 calculated. For Y=SR (Supplementary Table 8), C2 with a direct Cd–SR bond is favoured much more than the other isomers considered. Complexes with this C2-type connectivity but with Y=SSPPh2 have been characterized experimentally35. For Y=OR (Supplementary Table 9), C1 and C2 differ by only 2.3 kJ mol−1 and can therefore be considered iso-energetic. For Y=OOCR (Supplementary Table 10), C2 with the direct Cd–OOCR bonding is much more stable, similar to the case of Y=SR.

Consequently, for Y=NHR, B1 and C1 are preferred. For Y=OR, the selectivity is not obvious. For Y=SR and OOCR, B2 and C2 are favoured. Thus, the preference on the bonding skeleton calculated for intermediates B and C is similar. The nature of the chalcogenide also affects the relative stability of B1 versus B2 (Supplementary Table 18) as well as that of C1 versus C2 (Supplementary Table 19). For Y=NHR specifically, B2 and C2 are stabilized for E=S, whereas B1 and C1 are more stable for E=Te than for E=Se. For CdSe, our preliminary efforts on the kinetics associated with the putative pathway A+H−Y→B+Se=PPh2H are presented in Supplementary Figs 28–31 and Supplementary Note 5 with A1b for A and B2a for B. The trend of the kinetics computed seems to be in agreement with our experimental data showing the slowest disappearance of SeTOP (Fig. 1) and of 3 (Fig. 5) is from the batch with HY=RNH2.

Intermediates E and F are proposed as the very immediate precursors leading to monomers M2En with Compounds 1 and 2, respectively. E1 could have resulted from dimerization of B1 and E2 from B2. F1 could have resulted from dimerization of C1 and F2 from C2. Again, DFT calculations were performed to address the question of whether the various Y species are bound to Cd or to Se or to P. Clearly, E and F are computationally demanding. Generally, E isomers follow the trend of B isomers, and F follows C: low-energy B isomers lead to low-energy E, and C to F. In all cases, the four-membered ring Cd*–Se–Cd–Se–(Cd*) was found by minimization. For Y=NHR (Supplementary Table 11), E1 with the P–N bond is much more stable than E2 with the Cd–N bond by ∼150 kJ mol−1. For Y=SR (Supplementary Table 11), E2 with the Cd–S bond is more stable than E1, but the difference is smaller (32.7 kJ mol−1) than that (82.5 kJ mol−1) of B2 versus B1. For Y=OR (Supplementary Table 12), E1 is much more stable than E2, whereas B1 is similar to B2. For Y=OOCR (Supplementary Table 13), isomers such as E2 (with the Cd–Y bond) are the most stable ones found.

Intermediate F consists of two more E atoms than E. For Y=NHR (Supplementary Table 14), F1, with Se inserted between the Cd and P, namely Cd–Se–P–N, is 196.6 kJ mol−1 more stable than F2 with the direct Cd–N bond. For Y=SR (Supplementary Table 15), F2 is 78.0 kJ mol−1 more stable than F1. For Y=OR (Supplementary Table 15), F1 is 126.1 kJ mol−1 more stable than F2. For Y=OOCR (Supplementary Table 16), F2 is 78.8 kJ mol−1 more stable than F1. For Y=PPh2, D2 (a dimer of A) is more stable than D1 (equivalent to F1) by 86.6 kJ mol−1.

Although speculative, our current proposal is that E and F (or possibly higher oligomers such as from the dimerization of E and F)43 facilitate the release of 1 and 2, respectively. The release of Compound 1 is more apparent from E1 (via the M–P bond cleavage) than from E2; the Cd–P bond expected to break for E1 to lose 1 has a length of 2.66 Å (longer than 2.58 Å in B1). In addition, the release of Compound 2 is more apparent from F1 (via the M–E bond cleavage) than from F2; the Cd–Se bond expected to break for F1 to lose 2 has a length of 2.74 Å (longer than 2.69 Å in C1). For the release of 1 and 2 from E2 and F2, respectively, it seems reasonable that the formation of a Y–P bond (via the interaction of Y with Ph2P and with Ph2P(E)) could be accompanied by the cleavage of M–Y and P–E bonds44. It has been suggested that the oligomerization to [Cd2Se2]m is accompanied by a decrease in free energy for at least m=6 (ref. 24); this thermodynamic stability of [M2En]m may be the driving force of the overall reaction45.

Discussion

The molecular pathway of precursor evolution to monomers responsible for nucleation at low reaction temperature to semiconductor NCs has been recognized as a major challenge in advancing the design and synthesis of high-quality NCs with high synthetic reproducibility and particle yield. We have successfully rationalized a general reaction pathway for precursor evolution to monomers at low reaction temperatures from the mixture of MXn+ETOP+HPPh2+HY or MXn+E=PPh2H+HY. On the basis of the experimental and computational investigations, we propose the monomer of M2En and its formation accompanied by the loss of ligand Ph2P–Y (1) and Ph2P(E)–Y (2) via two competing paths. Experimentally, the combination of six metal ions of monovalent, divalent or trivalent, three chalcogenides and five types of additive HY (of carboxylic acid, dialkylphosphine, amine, thiol or alcohol) results in the P-containing products of Ph2P–Y (1) and Ph2P(E)–Y (2). The in-depth interpretation of the mechanism is supported by our DFT calculations. Our proposed pathway features a series of H-mediated ligand loss/exchange reactions triggered by dialkylphospine chalcogenides (such as E=PPh2H) to form intermediate A (M–(EPPh2)n), which leads to intermediate E (YPh2P–MEnM–PPh2Y, equation 1) and intermediate F (YPh2PE–MEnM–EPPh2Y, equation 2), the formation of which consists of dimerization and reaction with HY. The disassociation of ligand 1 from E and ligand 2 from F results in M2En monomers. Clearly, HY participates in the formation of monomers and thus could accelerate nucleation; meanwhile, a large amount of HY plays the role of a solvent and, thus, could retard nucleation. Importantly, the general pathway applies to metal chalcogenide NCs made from both toxic metals such as Cd (II) and Pb (II) and more benign metals such as Cu (I), Zn (II) and In (III). The insights into the chemical nature of the M2En monomer the building block, could provide the basis for the field to enable the manipulation of the chemical processes for rational design and synthesis of a variety of NCs with complex stoichiometry. The use of secondary phosphines together with beneficial additive HY should be a general and practical avenue to engineer metal chalcogenide NCs at low reaction temperatures with high quality, enhanced synthetic reproducibility and particle yield. We anticipate that the insight gained on the molecular pathway for precursor evolution into various types of M2En monomers may enable the field to synthesize sophisticated NCs, including phase-change materials, with better-controlled chemical processes via cation exchange as well as doping and co-doping with monovalent and trivalent metal ions46,47,48,49,50,51,52. We are actively exploring the correlation between the pathway of monomer formation with the formation of magic-size and regular QDs, aiming at the control of product properties including the size and size distribution. In addition, we believe that, similar to the endeavour of the development of organic syntheses, the basic chemistry reported embraces the advance of the NC synthesis from an empirical art to science with pathway-enabled design leading towards the full realization of the NC potential53,54,55,56,57.

Methods

31P NMR measurements

31P NMR was performed on a Bruker AV-III 400 spectrometer operating at 161.98 MHz, referenced with an external standard, 85% H3PO4. Usually, we used D1=2 s (64 scans total taking ∼3 min; unless mentioned otherwise). NMR samples were usually prepared and loaded in NMR tubes in a glovebox and properly sealed. All chemicals used are commercially available from Sigma-Aldrich and were used as received (or otherwise specified). The used ligands and additives are oleic acid (OA, tech. 90%), diphenylphosphine (HPPh2, 99%, Strem Chemicals), oleic amine (OLA, C18H35NH2, tech. 70%), 1-dodecanethiol (C12H25SH, 98%) and lauryl alcohol (C12H25OH, 98%). The elemental chalcogens used are sulfur (S, precipitated, Anachemia), selenium (Se, 200 mesh, 99.999%, Alfa Aeser) and tellurium (Te, 200 mesh, 99.8%). For the assignment of Compounds 1 and 2, sodium hydride (NaH, 95%, dry), chlorodiphenylphosphine (Ph2P–Cl, 97%, Alfa Aeser) were used. Compounds 1 (Ph2P–Y) and 2 (Ph2P(E)−Y) detected with NMR are related to the formation of monomers/solutes/NCs, and have been use to explore the formation of monomers since 2006 (refs 13, 15, 23, 24, 25). The P-containing products detected with 31P NMR are listed as follows: 1a (Ph2P–OOCC17H33), 1b (Ph2P–PPh2), 1c (Ph2P–NHC18H35), 1d (Ph2P–SC12H25), 1e (Ph2P–OC12H25), 2a (Ph2P(Se)–OOCC17H33), 2b (Ph2P(Se)–PPh2), 2b′ (Ph2P(S)–PPh2), 2c (Ph2P(Se)–NHC18H35), 2d Ph2P(Se)–SC12H25) and 2e Ph2P(Se)–OC12H25).

Computational

Our DFT calculations were performed using Gaussian 09, with ethyl groups (-C2H5) applied to represent the alkyl group of C17H33COO-, C18H35NH-, C12H25S- and C12H25O-; no simplicity was applied for the phenyl group of -PPh2. Full geometry optimizations were carried out to locate all of the stationary points via a hybrid B3LYP functional method with the SDD basis set and the corresponding effective core potential for the Cd, Se and Te atoms, and the all-electron 6-31++G(d, p) basis set for the other atoms of C, H, O, N, P and S, namely B3LYP/6-31++G(d, p), SDD. The use of effective core potential and all-electron basis was the same as before25. Systematic harmonic frequency calculations were performed to ensure that all the structures obtained are true minima on the potential energy surfaces. A polarized continuum model (PCM-SMD) with dielectric constant ɛ=2.0 was utilized to simulate the solvent effect of ODE via a hybrid M06 functional method with the same basis sets as mentioned above by performing single-point calculation on the optimized structures at the B3LYP/6-31++G(d, p), SDD level, namely M06//B3LYP/6-31++G(d, p), SDD. The charges and dominant occupancies of natural bond orbitals have been analysed with the help of the natural bond orbital analysis.

Data availability

The authors declare that all relevant data supporting the findings of this study are available from the authors on request.

Additional information

How to cite this article: Yu, K. et al. General low-temperature reaction pathway from precursors to monomers before nucleation of compound semiconductor nanocrystals. Nat. Commun. 7:12223 doi: 10.1038/ncomms12223 (2016).

Supplementary Material

Supplementary Information

Supplementary Figures 1-31, Supplementary Tables 1-25, Supplementary Notes 1-5, Supplementary Methods, Supplementary Discussion and Supplementary References.

ncomms12223-s1.pdf (6.6MB, pdf)

Acknowledgments

We Dr Keith U. Ingold for his support and beneficial discussions, Dr Frank S. Riehle for invaluable discussions, Dr X. Wu for transmission electron microscopy and Dr M. Yang and Dr X. Wang for discussions on the DFT. Q.Y.C. thanks National Research Council of Canada's summer student programme. K.Y. thanks National Natural Science Foundation of China (NSFC) 21573155 and the Fundamental Research Funds for the Central Universities SCU2015A002.

Footnotes

Author contributions K.Y. designed and directed this study. H.Y. designed and analysed the computational results. X.L. carried out NMR. T.Q. performed computation. Q.Y.C. and E.J.C.H. carried out in situ absorption monitoring. K.Y. and D.M.W. wrote the manuscript, with the help of the co-authors. All authors analysed and discussed the results and commented on the manuscript.

References

  1. Reineke S. Complementary LED technologies. Nat. Mater. 14, 459–462 (2015). [DOI] [PubMed] [Google Scholar]
  2. Editorial. Let there be light. Nat. Mater. 14, 453 (2015). [DOI] [PubMed] [Google Scholar]
  3. Fan F., Turkdogan S., Liu Z., Shelhammer D. & Ning C. Z. A monolithic white laser. Nat. Nanotechnol. 10, 796–803 (2015). [DOI] [PubMed] [Google Scholar]
  4. Tan C. K. & Tansu N. Nanostructured lasers: electrons and holes get closer. Nat. Nanotechnol. 10, 107–109 (2015). [DOI] [PubMed] [Google Scholar]
  5. Lan X., Masala S. & Sargent E. H. Charge-extraction strategies for colloidal quantum dot photovoltaics. Nat. Mater. 13, 233–240 (2014). [DOI] [PubMed] [Google Scholar]
  6. Chuang C. H. M., Brown P. R., Bulovic V. & Bawendi M. G. Improved performance and stability in quantum dot solar cells through band alignment engineering. Nat. Mater. 13, 796–801 (2014). [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Resch-Genger U., Grabolle M., Cavaliere-Jaricot S., Nitschke R. & Nann T. Quantum dots versus organic dyes as fluorescent labels. Nat. Methods 5, 763–775 (2008). [DOI] [PubMed] [Google Scholar]
  8. Yu J. H. et al. High-resolution three-photon biomedical imaging using doped ZnS nanocrystals. Nat. Mater. 13, 359–366 (2014). [DOI] [PubMed] [Google Scholar]
  9. Ming K. et al. Integrated quantum dot barcode smartphone optical device for wireless multiplexed diagnosis of infected patients. ACS Nano 9, 3060–3074 (2015). [DOI] [PubMed] [Google Scholar]
  10. Murray C. B., Norris D. J. & Bawendi M. G. Synthesis and characterization of nearly monodisperse CdE (E=sulfur, selenium, tellurium) semiconductor nanocrystallites. J. Am. Chem. Soc. 115, 8706–8715 (1993). [Google Scholar]
  11. Peng Z. A. & Peng X. Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. J. Am. Chem. Soc. 123, 183–184 (2001). [DOI] [PubMed] [Google Scholar]
  12. Yang Y. A., Wu H., Williams K. R. & Cao Y. C. Synthesis of CdSe and CdTe nanocrystals without precursor injection. Angew. Chem. Int. Ed. 44, 6712–6715 (2005). [DOI] [PubMed] [Google Scholar]
  13. Steckel J. S., Yen B. K. H., Oertel D. C. & Bawendi M. G. On the mechanism of lead chalcogenide nanocrystal formation. J. Am. Chem. Soc. 128, 13032–13033 (2006). [DOI] [PubMed] [Google Scholar]
  14. Joo J. et al. A reduction pathway in the synthesis of PbSe nanocrystals quantum dots. J. Am. Chem. Soc. 131, 10620–10628 (2009). [DOI] [PubMed] [Google Scholar]
  15. Evans C. M., Evans M. E. & Krauss T. D. Mysteries of TOPSe revealed: insights into quantum dot nucleation. J. Am. Chem. Soc. 132, 10973–10975 (2010). [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Cossairt B. M. & Owen J. S. At the interface of small molecules and quantum dots. Chem. Mater. 23, 3114–3119 (2011). [Google Scholar]
  17. Ouyang J. et al. Low-temperature approach to high-yield and reproducible syntheses of high-quality small-sized PbSe colloidal nanocrystals for photovoltaic applications. ACS Appl. Mater. Interfaces 3, 553–565 (2011). [DOI] [PubMed] [Google Scholar]
  18. Yu K., Ouyang J. & Leek D. M. In-situ observation of nucleation and growth of PbSe magic-sized nanoclusters and regular nanocrystals. Small 7, 2250–2262 (2011). [DOI] [PubMed] [Google Scholar]
  19. Yu K. et al. Highly-photoluminescent ZnSe nanocrystals via a non-injection-based approach with precursor reactivity elevated by a secondary phosphine. Chem. Commun. 47, 8811–8813 (2011). [DOI] [PubMed] [Google Scholar]
  20. Wang F. & Buhro W. R. Morphology control of cadmium selenide nanocrystals: insights into the roles of di-n-octylphosphine oxide (DOPO) and di-n-octylphosphinic acid (DOPA). J. Am. Chem. Soc. 134, 5369–5380 (2012). [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Yu K. et al. Ultraviolet ZnSe1-xSx gradiently-alloyed nanocrystals via a noninjection approach. ACS Appl. Mater. Interfaces 4, 4302–4311 (2012). [DOI] [PubMed] [Google Scholar]
  22. Yu K. et al. Low-temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications. ACS Appl. Mater. Interfaces 5, 2870–2880 (2013). [DOI] [PubMed] [Google Scholar]
  23. Yu K. et al. Effect of tertiary and secondary phosphines on low-temperature formation of quantum dots. Angew. Chem. Int. Ed. 52, 4823–4828 (2013). [DOI] [PubMed] [Google Scholar]
  24. Yu K. et al. The formation mechanism of binary semiconductor nanomaterials shared by single-source and dual-source precursor approaches at ambient temperature. Angew. Chem. Int. Ed. 52, 11034–11039 (2013). [DOI] [PubMed] [Google Scholar]
  25. Yu K. et al. Mechanistic study of the role of primary amines in precursor conversions to semiconductor nanocrystals at low temperature. Angew. Chem. Int. Ed. 53, 6896–6904 (2014). [DOI] [PubMed] [Google Scholar]
  26. Li L. S., Pradhan N., Wang Y. & Peng X. High quality ZnSe and ZnS nanocrystals formed by activating carboxylate precursors. Nano Lett. 4, 2261–2264 (2004). [Google Scholar]
  27. Xu S., Kumar S. & Nann T. Rapid synthesis of high-quality InP nanocrystals. J. Am. Chem. Soc. 128, 1054–1055 (2006). [DOI] [PubMed] [Google Scholar]
  28. Allen P. M., Walker B. J. & Bawendi M. G. Mechanistic insights into the formation of InP quantum dots. Angew. Chem. Int. Ed. 49, 760–762 (2010). [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Kruszynska M., Borchert H., Parisi J. & Kolny-Olesiak J. Synthesis and shape control of CuInS2 nanoparticles. J. Am. Chem. Soc. 132, 15976–15986 (2010). [DOI] [PubMed] [Google Scholar]
  30. Meinardi F. et al. Highly efficient large-area colourless luminescent solar concentrators using heavy-metal-free colloidal quantum dots. Nat. Nanotechnol. 10, 878–885 (2015). [DOI] [PubMed] [Google Scholar]
  31. Li L. et al. Efficient synthesis of highly luminescent copper indium sulfide-based core/shell nanocrystals with surprisingly long-lived emission. J. Am. Chem. Soc. 133, 1176–1179 (2011). [DOI] [PubMed] [Google Scholar]
  32. Liu H., Owen J. S. & Alivisatos A. P. Mechanistic study of precursor evolution in colloidal group II-VI semiconductor nanocrystal synthesis. J. Am. Chem. Soc. 129, 305–312 (2007). [DOI] [PubMed] [Google Scholar]
  33. Owen J. S., Chan E. M., Liu H. & Alivisatos A. P. Precursor conversion kinetics and the nucleation of cadmium selenide nanocrystals. J. Am. Chem. Soc. 132, 18206–18213 (2010). [DOI] [PubMed] [Google Scholar]
  34. Garcia-Rodriguez R. & Liu H. Mechanistic study of the synthesis of CdSe nanocrystals: release of selenium. J. Am. Chem. Soc. 134, 1400–1403 (2012). [DOI] [PubMed] [Google Scholar]
  35. Garcia-Rodriguez R. & Liu H. Mechanistic insights into the role of alkylamine in the synthesis of CdSe nanocrystals. J. Am. Chem. Soc. 136, 1968–1975 (2014). [DOI] [PubMed] [Google Scholar]
  36. Hendricks M. P., Cossairt B. M. & Owen J. S. The importance of nanocrystal precursor conversion kinetics: mechanism of the reaction between cadmium carboxylate and cadmium bis(diphenyldithiophosphinate). ACS Nano 6, 10054–10062 (2012). [DOI] [PubMed] [Google Scholar]
  37. Hendricks M. P., Campos M. P., Cleveland G. T., Plante J. L. & Owen J. S. A tunable library of substituted thiourea precursors to metal sulfide nanocrystals. Science 348, 1226–1230 (2015). [DOI] [PubMed] [Google Scholar]
  38. Zhang J. et al. Bright gradient-alloyed CdSexS1-x quantum dots exhibiting cyan-blue emission. Chem. Mater. 28, 618–625 (2016). [Google Scholar]
  39. Reed A. E., Curtiss L. A. & Weinhold F. Intermolecular interactions from a natural bond orbital, donor-acceptor viewpoint. Chem. Rev. 88, 899–926 (1988). [Google Scholar]
  40. Becke A. D. Density-functional thermochemistry. III. the role of exact exchange. J. Chem. Phys. 98, 5648–5652 (1993). [Google Scholar]
  41. Vajda S. et al. Subnanometre platinum clusters as highly active and selective catalysts for the oxidative dehydrogenation of propane. Nat. Mater. 8, 213–216 (2009). [DOI] [PubMed] [Google Scholar]
  42. Kazemi M. & Aqvist J. Chemical reaction mechanisms in solution from brute force computational Arrhenius plots. Nat. Commun. 6, 7293 (2015). [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Sharma S., Sivalingam K., Neese F. & Chan G. K. L. Low-energy spectrum of iron–sulfur clusters directly from many-particle quantum mechanics. Nat. Chem. 6, 927–933 (2014). [DOI] [PubMed] [Google Scholar]
  44. Khusnutdinova J. R. & Milstein D. Metal-ligand cooperation. Angew. Chem. Int. Ed. 54, 12236–12273 (2015). [DOI] [PubMed] [Google Scholar]
  45. Wang Y., He J., Liu C., Chong W. H. & Chen H. Thermodynamics versus kinetics in nanosynthesis. Angew. Chem. Int. Ed. 54, 2022–2051 (2015). [DOI] [PubMed] [Google Scholar]
  46. Lencer D. et al. A map for phase-change materials. Nat. Mater. 7, 972–977 (2008). [DOI] [PubMed] [Google Scholar]
  47. Polking M. J. et al. Ferroelectric order in individual nanometer-scale crystals. Nat. Mater. 11, 700–709 (2012). [DOI] [PubMed] [Google Scholar]
  48. Chen O. et al. Compact high-quality CdSe-CdS core–shell nanocrystals with narrow emission linewidths and suppressed blinking. Nat. Mater. 12, 445–451 (2013). [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Miszta K. et al. Selective cation exchange in the core region of Cu2–xSe/Cu2–xS core/shell nanocrystals. J. Am. Chem. Soc. 137, 12195–12198 (2015). [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Cooper J. K., Gul S., Lindley S. A., Yano J. & Zhang J. Z. Tunable photoluminescent core/shell Cu+doped ZnSe/ZnS quantum dots codoped with Al3+, Ga3+, or In3+. ACS Appl. Mater. Interfaces 7, 1005–10066 (2015). [DOI] [PubMed] [Google Scholar]
  51. Yu J. H. et al. Giant Zeeman splitting in nucleation-controlled doped CdSe:Mn2+ quantum nanoribbons. Nat. Mater. 9, 47–53 (2010). [DOI] [PubMed] [Google Scholar]
  52. Yang J. et al. Route to the smallest doped semiconductor: Mn2+-doped (CdSe)13 clusters. J. Am. Chem. Soc. 137, 12776–12779 (2015). [DOI] [PubMed] [Google Scholar]
  53. Weissleder R., Nahrendorf M. & Pittet M. J. Imaging macrophages with nanoparticles. Nat. Mater. 13, 125–138 (2014). [DOI] [PubMed] [Google Scholar]
  54. Kovalenko M. V. et al. Prospects of nanoscience with nanocrystals. ACS Nano 9, 1012–1057 (2015). [DOI] [PubMed] [Google Scholar]
  55. Curran D. P. Free at last. Nat. Chem. 4, 958–958 (2012). [DOI] [PubMed] [Google Scholar]
  56. Cui J. et al. Direct probe of spectral inhomogeneity reveals synthetic tunability of single-nanocrystal spectral linewidths. Nat. Chem. 5, 602–606 (2013). [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Bao J. & Bawendi M. G. A colloidal quantum dot spectrometer. Nature 523, 67–70 (2015). [DOI] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Information

Supplementary Figures 1-31, Supplementary Tables 1-25, Supplementary Notes 1-5, Supplementary Methods, Supplementary Discussion and Supplementary References.

ncomms12223-s1.pdf (6.6MB, pdf)

Data Availability Statement

The authors declare that all relevant data supporting the findings of this study are available from the authors on request.

Articles from Nature Communications are provided here courtesy of Nature Publishing Group

RESOURCES