Abstract
Lymphoid tissue of the endometrium was analysed by histological, immunohistological, and electron microscopical methods in 10 healthy uteri. A panel of monoclonal antibodies recognising macrophages (OKMI), HLA-DR antigen, B lymphocytes, T lymphocytes and their subsets, and dendritic reticulum cells was used in a two stage indirect immunoperoxidase labelling technique. Endometrial lymphoid tissue showed a remarkably consistent pattern of labelling in all cases. Lymphoid tissue was present in three sites: namely, (i) intraepithelial lymphocytes (predominantly T lymphocytes with occasional macrophages) associated with periglandular and sub-epithelial HLA-DR+, OKMI+ macrophages; (ii) interstitial lymphocytes and macrophages; (iii) lymphoid aggregates in the stratum basalis. These were composed mainly of T lymphocytes with a few B lymphocytes. Dendritic reticulum cells were found in those occasional lymphoid aggregates in which germinal centres were present. These features suggest that endometrial lymphoid tissue has many of the hallmarks of mucosal associated lymphoid tissue as found elsewhere in the body--for example, the bronchus and intestine. Endometrial lymphoid tissue appears to be unique, however, in that most of the stratum functionalis in which it is situated shows cyclical shedding during the menstrual cycle.
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- Bienenstock J., Johnston N., Perey D. Y. Bronchial lymphoid tissue. I. Morphologic characteristics. Lab Invest. 1973 Jun;28(6):686–692. [PubMed] [Google Scholar]
- EGLI G. E., NEWTON M. The transport of carbon particles in the human female reproductive tract. Fertil Steril. 1961 Mar-Apr;12:151–155. doi: 10.1016/s0015-0282(16)34084-5. [DOI] [PubMed] [Google Scholar]
- Geboes K., De Wolf-Peeters C., Rutgeerts P., Janssens J., Vantrappen G., Desmet V. Lymphocytes and Langerhans cells in the human oesophageal epithelium. Virchows Arch A Pathol Anat Histopathol. 1983;401(1):45–55. doi: 10.1007/BF00644788. [DOI] [PubMed] [Google Scholar]
- Lampert I. A., Suitters A. J., Chisholm P. M. Expression of Ia antigen on epidermal keratinocytes in graft-versus-host disease. Nature. 1981 Sep 10;293(5828):149–150. doi: 10.1038/293149a0. [DOI] [PubMed] [Google Scholar]
- Morris H. H., Gatter K. C., Stein H., Mason D. Y. Langerhans' cells in human cervical epithelium: an immunohistological study. Br J Obstet Gynaecol. 1983 May;90(5):400–411. doi: 10.1111/j.1471-0528.1983.tb08935.x. [DOI] [PubMed] [Google Scholar]
- Natali P. G., De Martino C., Quaranta V., Nicotra M. R., Frezza F., Pellegrino M. A., Ferrone S. Expression of Ia-like antigens in normal human nonlymphoid tissues. Transplantation. 1981 Jan;31(1):75–78. doi: 10.1097/00007890-198101000-00017. [DOI] [PubMed] [Google Scholar]
- Ogra P. L., Ogra S. S. Local antibody response to poliovaccine in the human female genital tract. J Immunol. 1973 May;110(5):1307–1311. [PubMed] [Google Scholar]
- Parrott D. M. The gut as a lymphoid organ. Clin Gastroenterol. 1976 May;5(2):211–228. [PubMed] [Google Scholar]
- Stein H., Gerdes J., Mason D. Y. The normal and malignant germinal centre. Clin Haematol. 1982 Oct;11(3):531–559. [PubMed] [Google Scholar]
- di Sant' Agnese P. A., De Mesy Jensen K. L. Dibasic staining of large epoxy tissue sections and applications to surgical pathology. Am J Clin Pathol. 1984 Jan;81(1):25–29. doi: 10.1093/ajcp/81.1.25. [DOI] [PubMed] [Google Scholar]