Abstract
Endometrial biopsies were obtained from 32 women with suspected pelvic inflammatory disease, of whom 23 (72%) had histopathological evidence of endometritis. Chlamydia trachomatis was isolated from the endometria of nine (39%) women (chlamydia group) but not from the other 14 (non-chlamydia group). Severe plasma cell endometritis and lymphoid follicles with transformed lymphocytes were significantly more common in the chlamydia group than in the non-chlamydia group. This suggests that C trachomatis is an invasive endometrial pathogen which often causes severe inflammation. The association was independent of predisposing factors such as use of intrauterine contraceptive devices.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ahlqvist J., Anderson L. Methyl green-pyronin staining: effects of fixation; use in routine pathology. Stain Technol. 1972 Jan;47(1):17–22. doi: 10.3109/10520297209116529. [DOI] [PubMed] [Google Scholar]
- Bard J., Levitt D. Chlamydia trachomatis stimulates human peripheral blood B lymphocytes to proliferate and secrete polyclonal immunoglobulins in vitro. Infect Immun. 1984 Jan;43(1):84–92. doi: 10.1128/iai.43.1.84-92.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLYDE W. A., Jr MYCOPLASMA SPECIES IDENTIFICATION BASED UPON GROWTH INHIBITION BY SPECIFIC ANTISERA. J Immunol. 1964 Jun;92:958–965. [PubMed] [Google Scholar]
- Czernobilsky B. Endometritis and infertility. Fertil Steril. 1978 Aug;30(2):119–130. doi: 10.1016/s0015-0282(16)43448-5. [DOI] [PubMed] [Google Scholar]
- FRIEND W. G. A polychrome stainfor differentiating precollagen from collagen. Stain Technol. 1963 May;38:204–206. [PubMed] [Google Scholar]
- Greenwood S. M., Moran J. J. Chronic endometritis: morphologic and clinical observations. Obstet Gynecol. 1981 Aug;58(2):176–184. [PubMed] [Google Scholar]
- Gump D. W., Dickstein S., Gibson M. Endometritis related to Chlamydia trachomatis infection. Ann Intern Med. 1981 Jul;95(1):61–63. doi: 10.7326/0003-4819-95-1-61. [DOI] [PubMed] [Google Scholar]
- Hare M. J., Toone E., Taylor-Robinson D., Evans R. T., Furr P. M., Cooper P., Oates J. K. Follicular cervicitis--colposcopic appearances and association with Chlamydia trachomatis. Br J Obstet Gynaecol. 1981 Feb;88(2):174–180. doi: 10.1111/j.1471-0528.1981.tb00964.x. [DOI] [PubMed] [Google Scholar]
- Ingerslev H. J., Møller B. R., Mårdh P. A. Chlamydia trachomatis in acute and chronic endometritis. Scand J Infect Dis Suppl. 1982;32:59–63. [PubMed] [Google Scholar]
- Mårdh P. A. An overview of infectious agents of salpingitis, their biology, and recent advances in methods of detection. Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 2):933–951. doi: 10.1016/0002-9378(80)91084-4. [DOI] [PubMed] [Google Scholar]
- Mårdh P. A., Møller B. R., Ingerselv H. J., Nüssler E., Weström L., Wølner-Hanssen P. Endometritis caused by Chlamydia trachomatis. Br J Vener Dis. 1981 Jun;57(3):191–195. doi: 10.1136/sti.57.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mårdh P. A., Ripa T., Svensson L., Weström L. Chilamydia trachomatis infection in patients with acute salpingitis. N Engl J Med. 1977 Jun 16;296(24):1377–1379. doi: 10.1056/NEJM197706162962403. [DOI] [PubMed] [Google Scholar]
- Paavonen J., Aine R., Teisala K., Heinonen P. K., Punnonen R. Comparison of endometrial biopsy and peritoneal fluid cytologic testing with laparoscopy in the diagnosis of acute pelvic inflammatory disease. Am J Obstet Gynecol. 1985 Mar 1;151(5):645–650. doi: 10.1016/0002-9378(85)90156-5. [DOI] [PubMed] [Google Scholar]
- Paavonen J., Purola E. Cytologic findings in cervical chlamydial infection. Med Biol. 1980 Jun;58(3):174–178. [PubMed] [Google Scholar]
- Paavonen J., Teisala K., Heinonen P. K., Aine R., Miettinen A., Lehtinen M., Grönroos P. Endometritis and acute salpingitis associated with Chlamydia trachomatis and herpes simplex virus type two. Obstet Gynecol. 1985 Feb;65(2):288–291. [PubMed] [Google Scholar]
- Paavonen J., Vesterinen E., Meyer B., Saksela E. Colposcopic and histologic findings in cervical chlamydial infection. Obstet Gynecol. 1982 Jun;59(6):712–715. [PubMed] [Google Scholar]
- Peacock W. L., Jr Method for preparing Neisseria gonorrhoeae fluorescent antibody conjugate. Public Health Rep. 1970 Aug;85(8):733–738. [PMC free article] [PubMed] [Google Scholar]
- Punnonen R., Terho P., Nikkanen V., Meurman O. Chlamydial serology in infertile women by immunofluorescence. Fertil Steril. 1979 Jun;31(6):656–659. doi: 10.1016/s0015-0282(16)44056-2. [DOI] [PubMed] [Google Scholar]
- Ripa K. T., Mårdh P. A. Cultivation of Chlamydia trachomatis in cycloheximide-treated mccoy cells. J Clin Microbiol. 1977 Oct;6(4):328–331. doi: 10.1128/jcm.6.4.328-331.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts T. H., Ng A. B. Chronic lymphocytic cervicitis: cytologic and histopathologic manifestations. Acta Cytol. 1975 May-Jun;19(3):235–243. [PubMed] [Google Scholar]
- Rotterdam H. Chronic endometritis. A clinicopathologic study. Pathol Annu. 1978;13(Pt 2):209–231. [PubMed] [Google Scholar]
- Shepard M. C., Lunceford C. D. Differential agar medium (A7) for identification of Ureaplasma urealyticum (human T mycoplasmas) in primary cultures of clinical material. J Clin Microbiol. 1976 Jun;3(6):613–625. doi: 10.1128/jcm.3.6.613-625.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shepard M. C., Lunceford C. D. Serological typing of Ureaplasma urealyticum isolates from urethritis patients by an agar growth inhibition method. J Clin Microbiol. 1978 Nov;8(5):566–574. doi: 10.1128/jcm.8.5.566-574.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stray-Pedersen B., Bruu A. L., Molne K. Infertility and uterine colonization with Ureaplasma urealyticum. Acta Obstet Gynecol Scand. 1982;61(1):21–24. doi: 10.3109/00016348209156945. [DOI] [PubMed] [Google Scholar]
- Tully J. G., Whitcomb R. F., Clark H. F., Williamson D. L. Pathogenic mycoplasmas: cultivation and vertebrate pathogenicity of a new spiroplasma. Science. 1977 Mar 4;195(4281):892–894. doi: 10.1126/science.841314. [DOI] [PubMed] [Google Scholar]
- Wølner-Hanssen P., Mårdh P. A., Møller B., Weström L. Endometrial infection in women with Chlamydial salpingitis. Sex Transm Dis. 1982 Apr-Jun;9(2):84–88. doi: 10.1097/00007435-198204000-00006. [DOI] [PubMed] [Google Scholar]