Abstract
Twenty five specimens of branchial cyst from the same number of patients have been examined. On staining with haematoxylin and eosin a consistent finding was that the mural lymphoid follicles were always aligned with their mantle zones towards the luminal epithelium. With conventional staining lymphatic sinuses were noted in 17 of the specimens, but with immunohistochemical staining these structures were apparent in 23 cysts. Their frequent occurrence in branchial cysts supports the theory that these lesions are derived from epithelial inclusions in lymph nodes. Immunohistochemical techniques for a range of other markers, using polyclonal and monoclonal antisera, showed a distribution of lymphoid and non-lymphoid tissue elements, as seen in lymph nodes and, for example, palatine tonsils. The lining luminal epithelium also shared many features in common with the crypt epithelium of tonsils.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burnett D., Crocker J., Vaughan A. T. Synthesis of cathepsin B by cells derived from the HL60 promyelocytic leukaemia cell line. J Cell Physiol. 1983 Jun;115(3):249–254. doi: 10.1002/jcp.1041150306. [DOI] [PubMed] [Google Scholar]
- Crocker J., Burnett D., Jones E. L. Immunohistochemical demonstration of cathepsin B in the macrophages of benign and malignant lymphoid tissues. J Pathol. 1984 Jan;142(1):87–94. doi: 10.1002/path.1711420114. [DOI] [PubMed] [Google Scholar]
- Crocker J., Jenkins R., Burnett D. Immunohistochemical demonstration of leucocyte elastase in human tissues. J Clin Pathol. 1984 Oct;37(10):1114–1118. doi: 10.1136/jcp.37.10.1114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crocker J., Smith P. J. Immunohistochemical localisation of factor VIII-related antigen in Hodgkin's disease. J Clin Pathol. 1984 Jan;37(1):37–44. doi: 10.1136/jcp.37.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crocker J. The enzyme histochemistry of lymphoid and non-lymphoid cells of the human palatine tonsil: a basis for the study of lymphomas. J Pathol. 1981 May;134(1):81–95. doi: 10.1002/path.1711340109. [DOI] [PubMed] [Google Scholar]
- Curran R. C., Gregory J., Jones E. L. The distribution of immunoglobulin and other plasma proteins in human reactive lymph nodes. J Pathol. 1982 Apr;136(4):307–332. doi: 10.1002/path.1711360406. [DOI] [PubMed] [Google Scholar]
- Curran R. C., Jones E. L. Immunoglobulin-containing cells in human tonsils as demonstrated by immunohistochemistry. Clin Exp Immunol. 1977 Apr;28(1):103–115. [PMC free article] [PubMed] [Google Scholar]
- Howie A. J., Crocker J. The lining of branchial cysts studied by electron microscopy and enzyme histochemistry. J Pathol. 1981 Nov;135(3):189–197. doi: 10.1002/path.1711350304. [DOI] [PubMed] [Google Scholar]
- Howie A. J. Scanning and transmission electron microscopy on the epithelium of human palatine tonsils. J Pathol. 1980 Feb;130(2):91–98. doi: 10.1002/path.1711300205. [DOI] [PubMed] [Google Scholar]
- Jones E. L., Crocker J., Gregory J., Guibarra M., Curran R. C. Angiofollicular lymph node hyperplasia (Castleman's disease): an immunohistochemical and enzyme-histochemical study of the hyaline-vascular form of lesion. J Pathol. 1984 Oct;144(2):131–147. doi: 10.1002/path.1711440208. [DOI] [PubMed] [Google Scholar]
- Maran A. G., Buchanan D. R. Branchial cysts, sinuses and fistulae. Clin Otolaryngol Allied Sci. 1978 Feb;3(1):77–92. doi: 10.1111/j.1365-2273.1978.tb00670.x. [DOI] [PubMed] [Google Scholar]