Abstract
A stereological analysis of epithelial structure at the lateral surface of the tongue showed that iron deficiency anaemia was associated with reduced epithelial thickness despite the absence of overt mucosal abnormalities. The epithelial atrophy was entirely due to a reduction in the size and number of cells in the maturation compartment. By contrast, the progenitor cell compartment was increased in thickness due to an increase in the number of cells. This hyperplastic reaction may be a trophic response to the overall loss of epithelium in this condition.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAIRD I. M., DODGE O. G., PALMER F. J., WAWMAN R. J. The tongue and oesophagus in iron-deficiency anaemia and the effect of iron therapy. J Clin Pathol. 1961 Nov;14:603–609. doi: 10.1136/jcp.14.6.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BERENBAUM M. C. The use of bovine albumin in the preparation of marrow and blood films. J Clin Pathol. 1956 Nov;9(4):381–383. doi: 10.1136/jcp.9.4.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BEVERIDGE B. R., BANNERMAN R. M., EVANSON J. M., WITTS L. J. HYPOCHROMIC ANAEMIA. A RETROSPECTIVE STUDY AND FOLLOW-UP OF 378 IN-PATIENTS. Q J Med. 1965 Apr;34:145–161. [PubMed] [Google Scholar]
- Eveson J. W., MacDonald D. G. Quantitative histological changes during early experimental carcinogenesis in the hamster cheek pouch. Br J Dermatol. 1978 Jun;98(6):639–644. doi: 10.1111/j.1365-2133.1978.tb03582.x. [DOI] [PubMed] [Google Scholar]
- Franklin C. D., Craig G. T. Stereological quantification of histological parameters in normal hamster cheek pouch epithelium. Arch Oral Biol. 1978;23(5):337–345. doi: 10.1016/0003-9969(78)90090-0. [DOI] [PubMed] [Google Scholar]
- JACOBS A. Carbohydrates and sulphur-containing compounds in the anaemic buccal epithelium. J Clin Pathol. 1961 Nov;14:610–614. doi: 10.1136/jcp.14.6.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JACOBS A. The buccal mucosa in anaemia. J Clin Pathol. 1960 Nov;13:463–468. doi: 10.1136/jcp.13.6.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MONTO R. W., RIZEK R. A., FINE G. Observations on the exfolative cytology and histology of the oral mucous membranes in iron deficiency. Oral Surg Oral Med Oral Pathol. 1961 Aug;14:965–974. doi: 10.1016/0030-4220(61)90013-5. [DOI] [PubMed] [Google Scholar]
- Ranasinghe A. W., Warnakulasuriya K. A., Tennekoon G. E., Seneviratna B. Oral mucosal changes in iron deficiency anemia in a Sri Lankan female population. Oral Surg Oral Med Oral Pathol. 1983 Jan;55(1):29–32. doi: 10.1016/0030-4220(83)90302-x. [DOI] [PubMed] [Google Scholar]
- Rennie J. S., MacDonald D. G. Cell kinetics of hamster ventral tongue epithelium in iron deficiency. Arch Oral Biol. 1984;29(3):195–199. doi: 10.1016/0003-9969(84)90054-2. [DOI] [PubMed] [Google Scholar]
- Rennie J. S., MacDonald D. G., Dagg J. H. Quantitative analysis of human buccal epithelium in iron deficiency anaemia. J Oral Pathol. 1982 Feb;11(1):39–46. doi: 10.1111/j.1600-0714.1982.tb00141.x. [DOI] [PubMed] [Google Scholar]
- Scott J., Valentine J. A., St Hill C. A., Balasooriya B. A. A quantitative histological analysis of the effects of age and sex on human lingual epithelium. J Biol Buccale. 1983 Dec;11(4):303–315. [PubMed] [Google Scholar]
