Abstract
Six tumours of the lung initially classified as clear cell carcinoma, were studied. Examination of further material by light and electron microscopy showed adenocarcinomatous differentiation in three cases and squamous differentiation in two. One case showed the features of a large cell anaplastic carcinoma. The clear appearance of the cytoplasm in paraffin sections was due to accumulations of glycogen that were partially removed during processing. It is concluded that clear cell carcinoma is not a single and separate entity.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Churg A. The fine structure of large cell undifferentiated carcinoma of the lung. Evidence for its relation to squamous cell carcinomas and adenocarcinomas. Hum Pathol. 1978 Mar;9(2):143–156. doi: 10.1016/s0046-8177(78)80105-1. [DOI] [PubMed] [Google Scholar]
- Coppola G., Bancale A., Oliva G. Il carcinoma "a cellule chiare" del polmone. Morfologia, istochimica, istogenesi. Ann Ist Carlo Forlanini. 1965;25(3):280–297. [PubMed] [Google Scholar]
- Drut R., Alicia Attadema G., Osvaldo Giménez P., Chiappe L. Carcinomas de pulmón con células claras. Arch Fund Roux Ocefa. 1970;4(1):79–86. [PubMed] [Google Scholar]
- Hoch W. S., Patchefsky A. S., Takeda M., Gordon G. Benign clear cell tumor of the lung. An ultrastructural study. Cancer. 1974 May;33(5):1328–1336. doi: 10.1002/1097-0142(197405)33:5<1328::aid-cncr2820330518>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
- Katzenstein A. L., Prioleau P. G., Askin F. B. The histologic spectrum and significance of clear-cell change in lung carcinoma. Cancer. 1980 Mar 1;45(5):943–947. doi: 10.1002/1097-0142(19800301)45:5<943::aid-cncr2820450518>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- MORGAN A. D., MACKENZIE D. H. CLEAR-CELL CARCINOMA OF THE LUNG. J Pathol Bacteriol. 1964 Jan;87:25–27. doi: 10.1002/path.1700870104. [DOI] [PubMed] [Google Scholar]
- Sidhu G. S., Forrester E. M. Glycogen-rich Clara cell-type bronchiolo-alveolar carcinoma: light and electron microscopic study. Cancer. 1977 Nov;40(5):2209–2215. doi: 10.1002/1097-0142(197711)40:5<2209::aid-cncr2820400531>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- WALTER J. B., PRYCE D. M. The histology of lung cancer. Thorax. 1955 Jun;10(2):107–116. doi: 10.1136/thx.10.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zolliker A., Jacques J., Goldstein A. S. Benign clear cell tumor of the lung. Arch Pathol Lab Med. 1979 Sep;103(10):526–530. [PubMed] [Google Scholar]