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. 1985 Nov;38(11):1247–1251. doi: 10.1136/jcp.38.11.1247

Fertility in young men and women after treatment for lymphoma: a study of a population.

D J King, M A Ratcliffe, A A Dawson, B Bennett, J E Macgregor, A I Klopper
PMCID: PMC499421  PMID: 3934229

Abstract

All young patients in the Grampian area attending the lymphoma review clinic who had received first line treatment for Hodgkin's disease and had attained complete remission without subsequent relapse were studied between 1980 and 1983. Chemotherapy with MVPP (mustine, vinblastine, procarbazine, and prednisolone) had more severe effects on the fertility of men than that of women; younger women and those taking oral contraceptives were more likely to retain fertility than those over 30 or not taking the pill at the time of chemotherapy, but these two effects could not be differentiated. Premature menopause was common after treatment with MVPP. Mantle radiotherapy had no discernible effect on gonadal function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chapman R. M., Sutcliffe S. B., Malpas J. S. Cytotoxic-induced ovarian failure in Hodgkin's disease. II. Effects on sexual function. JAMA. 1979 Oct 26;242(17):1882–1884. [PubMed] [Google Scholar]
  2. Chapman R. M., Sutcliffe S. B., Malpas J. S. Cytotoxic-induced ovarian failure in women with Hodgkin's disease. I. Hormone function. JAMA. 1979 Oct 26;242(17):1877–1881. [PubMed] [Google Scholar]
  3. Chapman R. M., Sutcliffe S. B., Malpas J. S. Male gonadal dysfunction in Hodgkin's disease. A prospective study. JAMA. 1981 Apr 3;245(13):1323–1328. [PubMed] [Google Scholar]
  4. Chapman R. M., Sutcliffe S. B., Rees L. H., Edwards C. R., Malpas J. S. Cyclical combination chemotherapy and gonadal function. Retrospective study in males. Lancet. 1979 Feb 10;1(8111):285–289. doi: 10.1016/s0140-6736(79)90701-3. [DOI] [PubMed] [Google Scholar]
  5. Furuyama S., Mayes D. M., Nugent C. A. A radioimmunoassay for plasma testosterone. Steroids. 1970 Oct;16(4):415–428. doi: 10.1016/s0039-128x(70)80124-6. [DOI] [PubMed] [Google Scholar]
  6. Horning S. J., Hoppe R. T., Kaplan H. S., Rosenberg S. A. Female reproductive potential after treatment for Hodgkin's disease. N Engl J Med. 1981 Jun 4;304(23):1377–1382. doi: 10.1056/NEJM198106043042301. [DOI] [PubMed] [Google Scholar]
  7. Hotchkiss J., Atkinson L. E., Knobil E. Time course of serum estrogen and luteinizing hormone (LH) concentrations during the menstrual cycle of the rhesus monkey. Endocrinology. 1971 Jul;89(1):177–183. doi: 10.1210/endo-89-1-177. [DOI] [PubMed] [Google Scholar]
  8. Johansson E. D. Progesterone levels in peripheral plasma during the luteal phase of the normal human menstrual cycle measured by a rapid competitive protein binding technique. Acta Endocrinol (Copenh) 1969 Aug;61(4):592–606. doi: 10.1530/acta.0.0610592. [DOI] [PubMed] [Google Scholar]
  9. Schilsky R. L., Sherins R. J., Hubbard S. M., Wesley M. N., Young R. C., DeVita V. T. Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin's disease. Am J Med. 1981 Oct;71(4):552–556. doi: 10.1016/0002-9343(81)90205-9. [DOI] [PubMed] [Google Scholar]
  10. Shaaban M. M., Klopper A. Plasma oestradiol and progesterone concentration in the normal menstrual cycle. J Obstet Gynaecol Br Commonw. 1973 Sep;80(9):776–782. doi: 10.1111/j.1471-0528.1973.tb11218.x. [DOI] [PubMed] [Google Scholar]
  11. Sherins R. J., DeVita V. T., Jr Effect of drug treatment for lymphoma on male reproductive capacity. Studies of men in remission after therapy. Ann Intern Med. 1973 Aug;79(2):216–220. doi: 10.7326/0003-4819-79-2-216. [DOI] [PubMed] [Google Scholar]
  12. Sherins R. J., Olweny C. L., Ziegler J. L. Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin's disease. N Engl J Med. 1978 Jul 6;299(1):12–16. doi: 10.1056/NEJM197807062990103. [DOI] [PubMed] [Google Scholar]
  13. Van Thiel D. H., Sherins R. J., Myers G. H., Jr, De Vita V. T., Jr Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man. J Clin Invest. 1972 Apr;51(4):1009–1019. doi: 10.1172/JCI106861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Vigersky R. A., Chapman R. M., Berenberg J., Glass A. R. Testicular dysfunction in untreated Hodgkin's disease. Am J Med. 1982 Oct;73(4):482–486. doi: 10.1016/0002-9343(82)90325-4. [DOI] [PubMed] [Google Scholar]
  15. Waxman J. H., Terry Y. A., Wrigley P. F., Malpas J. S., Rees L. H., Besser G. M., Lister T. A. Gonadal function in Hodgkin's disease: long-term follow-up of chemotherapy. Br Med J (Clin Res Ed) 1982 Dec 4;285(6355):1612–1613. doi: 10.1136/bmj.285.6355.1612. [DOI] [PMC free article] [PubMed] [Google Scholar]

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