Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1985 Oct;38(10):1100–1105. doi: 10.1136/jcp.38.10.1100

Follicular thyroid tumours: a study of laminin and type IV collagen in basement membrane and endothelium.

C H Kendall, P R Sanderson, J Cope, I C Talbot
PMCID: PMC499449  PMID: 3902896

Abstract

Immunocytochemical stains for laminin and type IV collagen can be used as markers for basement membrane and vascular endothelium. Thirty four follicular thyroid lesions were examined using these techniques to investigate two aspects: firstly, the relation between the extent of invasion and the integrity of basement membrane; secondly, whether the techniques could enhance the detection of tumour vascular invasion. The results showed that although basement membrane was lost in widely invasive tumours, preservation was seen in most but not all encapsulated tumours. The potential for improved recognition of vascular invasion was also found.

Full text

PDF
1100

Images in this article

1101Image
on p.1101
1101Image
on p.1101
1102Image
on p.1102
1102Image
on p.1102
1102Image
on p.1102
1103Image
on p.1103
1103Image
on p.1103

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albrechtsen R., Nielsen M., Wewer U., Engvall E., Ruoslahti E. Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin. Cancer Res. 1981 Dec;41(12 Pt 1):5076–5081. [PubMed] [Google Scholar]
  2. Barsky S. H., Siegal G. P., Jannotta F., Liotta L. A. Loss of basement membrane components by invasive tumors but not by their benign counterparts. Lab Invest. 1983 Aug;49(2):140–147. [PubMed] [Google Scholar]
  3. Bettelheim R., Mitchell D., Gusterson B. A. Immunocytochemistry in the identification of vascular invasion in breast cancer. J Clin Pathol. 1984 Apr;37(4):364–366. doi: 10.1136/jcp.37.4.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Birembaut P., Caron Y., Adnet J. J., Foidart J. M. Usefulness of basement membrane markers in tumoural pathology. J Pathol. 1985 Apr;145(4):283–296. doi: 10.1002/path.1711450402. [DOI] [PubMed] [Google Scholar]
  5. Burtin P., Chavanel G., Foidart J. M., Martin E. Antigens of the basement membrane and the peritumoral stroma in human colonic adenocarcinomas: an immunofluorescence study. Int J Cancer. 1982 Jul 15;30(1):13–20. doi: 10.1002/ijc.2910300104. [DOI] [PubMed] [Google Scholar]
  6. Cady B., Sedgwick C. E., Meissner W. A., Bookwalter J. R., Romagosa V., Werber J. Changing clinical, pathologic, therapeutic, and survival patterns in differentiated thyroid carcinoma. Ann Surg. 1976 Nov;184(5):541–553. doi: 10.1097/00000658-197611000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ekblom P., Miettinen M., Forsman L., Andersson L. C. Basement membrane and apocrine epithelial antigens in differential diagnosis between tubular carcinoma and sclerosing adenosis of the breast. J Clin Pathol. 1984 Apr;37(4):357–363. doi: 10.1136/jcp.37.4.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ekblom P., Miettinen M., Rapola J., Foidart J. M. Demonstration of laminin, a basement membrane glycoprotein, in routinely processed formalin-fixed human tissues. Histochemistry. 1982;75(3):301–307. doi: 10.1007/BF00496733. [DOI] [PubMed] [Google Scholar]
  9. Evans H. L. Follicular neoplasms of the thyroid. A study of 44 cases followed for a minimum of 10 years, with emphasis on differential diagnosis. Cancer. 1984 Aug 1;54(3):535–540. doi: 10.1002/1097-0142(19840801)54:3<535::aid-cncr2820540325>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  10. Foidart J. M., Bere E. W., Jr, Yaar M., Rennard S. I., Gullino M., Martin G. R., Katz S. I. Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. Lab Invest. 1980 Mar;42(3):336–342. [PubMed] [Google Scholar]
  11. Forster S. J., Talbot I. C., Critchley D. R. Laminin and fibronectin in rectal adenocarcinoma: relationship to tumour grade, stage and metastasis. Br J Cancer. 1984 Jul;50(1):51–61. doi: 10.1038/bjc.1984.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HAZARD J. B., KENYON R. Encapsulated angioinvasive carcinoma (angioinvasive adenoma) of thyroid gland. Am J Clin Pathol. 1954 Jul;24(7):755–766. doi: 10.1093/ajcp/24.7.755. [DOI] [PubMed] [Google Scholar]
  13. Harach H. R., Jasani B., Williams E. D. Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid. J Clin Pathol. 1983 Sep;36(9):1050–1054. doi: 10.1136/jcp.36.9.1050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Johannessen J. V., Gould V. E., Jao W. The fine structure of human thyroid cancer. Hum Pathol. 1978 Jul;9(4):385–400. doi: 10.1016/s0046-8177(78)80025-2. [DOI] [PubMed] [Google Scholar]
  15. Kahn N. F., Perzin K. H. Follicular carcinoma of the thyroid: an evaluation of the histologic criteria used for diagnosis. Pathol Annu. 1983;18(Pt 1):221–253. [PubMed] [Google Scholar]
  16. Miettinen M., Virtanen I. Expression of laminin in thyroid gland and thyroid tumors: an immunohistologic study. Int J Cancer. 1984 Jul 15;34(1):27–30. doi: 10.1002/ijc.2910340106. [DOI] [PubMed] [Google Scholar]
  17. Schröder S., Pfannschmidt N., Dralle H., Arps H., Böcker W. The encapsulated follicular carcinoma of the thyroid. A clinicopathologic study of 35 cases. Virchows Arch A Pathol Anat Histopathol. 1984;402(3):259–273. doi: 10.1007/BF00695080. [DOI] [PubMed] [Google Scholar]
  18. Yaoita H., Foidart J. M., Katz S. I. Localization of the collagenous component in skin basement membrane. J Invest Dermatol. 1978 Apr;70(4):191–193. doi: 10.1111/1523-1747.ep12541313. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES