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. 1985 Oct;38(10):1175–1178. doi: 10.1136/jcp.38.10.1175

Defective activation of neutrophils after splenectomy.

P N Foster, R P Bolton, K L Cotter, M S Losowsky
PMCID: PMC499464  PMID: 3902902

Abstract

Neutrophil chemotaxis and phagocytosis in the presence of serum from 20 patients who had undergone splenectomy and from 15 healthy volunteers was studied. The mean distance migrated by normal neutrophils in the presence of serum from the patients after splenectomy was significantly less than that when normal serum was used (p less than 0.005). The percentage of neutrophils phagocytosing a yeast was also significantly reduced in the presence of serum from patients after splenectomy (p less than 0.02). In addition, when neutrophils from these patients were studied both chemotaxis and phagocytosis were enhanced in normal compared with autologous serum (p less than 0.05).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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