Abstract
The term "dysplastic" melanocytic naevus has recently been used to describe pigmented naevi with unusual histological and clinical features. There is currently no clear clinical or pathological definition of the term, and this has led to a lack of comparability of material described in reports on these lesions. As a result of careful histological study and a clinicopathological correlation of 100 naevi, we suggest that three distinct groups of histopathological features distinguish so called dysplastic naevi from banal melanocytic naevi. These are architectural atypia, cytological atypia, and a host response. Description of each of these features in routine reports and in published series in place of the loose use of the term "dysplastic" would enable comparisons to be made between series of melanocytic lesions reported from different centres. In the course of this study we observed a considerably increased incidence of naevus type giant cells in the dermal portion of the atypical naevi. These giant cells should not be confused with possibly premalignant cytological atypia.
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- Ackerman A. B., Mihara I. Dysplasia, dysplastic melanocytes, dysplastic nevi, the dysplastic nevus syndrome, and the relation between dysplastic nevi and malignant melanomas. Hum Pathol. 1985 Jan;16(1):87–91. [PubMed] [Google Scholar]
- Clark W. H., Jr, Reimer R. R., Greene M., Ainsworth A. M., Mastrangelo M. J. Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'. Arch Dermatol. 1978 May;114(5):732–738. [PubMed] [Google Scholar]
- Cook M. G., Robertson I. Melanocytic dysplasia and melanoma. Histopathology. 1985 Jun;9(6):647–658. doi: 10.1111/j.1365-2559.1985.tb02845.x. [DOI] [PubMed] [Google Scholar]
- Elder D. E., Goldman L. I., Goldman S. C., Greene M. H., Clark W. H., Jr Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer. 1980 Oct 15;46(8):1787–1794. doi: 10.1002/1097-0142(19801015)46:8<1787::aid-cncr2820460816>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
- Elder D. E., Green M. H., Guerry D., 4th, Kraemer K. H., Clark W. H., Jr The dysplastic nevus syndrome: our definition. Am J Dermatopathol. 1982 Oct;4(5):455–460. doi: 10.1097/00000372-198210000-00014. [DOI] [PubMed] [Google Scholar]
- Reimer R. R., Clark W. H., Jr, Greene M. H., Ainsworth A. M., Fraumeni J. F., Jr Precursor lesions in familial melanoma. A new genetic preneoplastic syndrome. JAMA. 1978 Feb 20;239(8):744–746. [PubMed] [Google Scholar]
- Rhodes A. R., Harrist T. J., Day C. L., Mihm M. C., Jr, Fitzpatrick T. B., Sober A. J. Dysplastic melanocytic nevi in histologic association with 234 primary cutaneous melanomas. J Am Acad Dermatol. 1983 Oct;9(4):563–574. doi: 10.1016/s0190-9622(83)70171-4. [DOI] [PubMed] [Google Scholar]
- Wagner B. M. The surgical pathology report. Hum Pathol. 1984 Jan;15(1):1–1. doi: 10.1016/s0046-8177(84)80325-1. [DOI] [PubMed] [Google Scholar]