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. 1997 Jan;50(1):50–53. doi: 10.1136/jcp.50.1.50

Increased soluble ICAM-1 concentration and impaired delayed-type hypersensitivity skin tests in patients with chronic liver disease.

M Pirisi 1, D Vitulli 1, E Falleti 1, C Fabris 1, G Soardo 1, M Del Forno 1, P Bardus 1, F Gonano 1, E Bartoli 1
PMCID: PMC499713  PMID: 9059357

Abstract

AIMS/BACKGROUND: Soluble ICAM-1 may act as an antagonist of the membrane bound form, which is essential for the adhesion of leucocytes to endothelial cells. The aim of this study was to investigate whether the presence of high concentrations of soluble ICAM-1 are related to the impairment of delayed-type hypersensitivity reactions. METHODS: The study population comprised 73 patients (53 men and 20 women) with chronic liver disease (19 with chronic hepatitis, 36 with cirrhosis and 18 with hepatocellular carcinoma), and 21 age-matched controls (11 men and 10 women). Serum soluble ICAM-1 was measured using an enzyme immunoassay. Skin tests for seven different antigens (tetanus, diphtheria, streptococcus group C, tuberculin, Candida, tricophyton, and proteus) were considered positive when diameters > or = 2 mm were recorded; the diameters of positive tests were added to calculate a cumulative score. RESULTS: Patients with chronic liver disease had fewer positive skin tests (median 2) and a lower cumulative score (median 7) than controls (median 3 and 12, respectively). Multivariate analysis suggested the existence of an independent association between alkaline phosphatase and anergy to skin tests and between soluble ICAM-1 concentrations and the cumulative score. CONCLUSIONS: The strong association observed between increased soluble ICAM-1 concentrations and impairment of delayed-type hypersensitivity skin tests suggests that soluble ICAM-1 may be implicated in the immune depression seen in patients with chronic liver disease.

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Selected References

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  1. Adams D. H., Mainolfi E., Burra P., Neuberger J. M., Ayres R., Elias E., Rothlein R. Detection of circulating intercellular adhesion molecule-1 in chronic liver diseases. Hepatology. 1992 Sep;16(3):810–814. doi: 10.1002/hep.1840160330. [DOI] [PubMed] [Google Scholar]
  2. Adams D. H., Mainolfi E., Elias E., Neuberger J. M., Rothlein R. Detection of circulating intercellular adhesion molecule-1 after liver transplantation--evidence of local release within the liver during graft rejection. Transplantation. 1993 Jan;55(1):83–87. doi: 10.1097/00007890-199301000-00016. [DOI] [PubMed] [Google Scholar]
  3. Ahmed A. R., Blose D. A. Delayed-type hypersensitivity skin testing. A review. Arch Dermatol. 1983 Nov;119(11):934–945. [PubMed] [Google Scholar]
  4. Bailey T. C., Fraser V. J., Spitznagel E. L., Dunagan W. C. Risk factors for a positive tuberculin skin test among employees of an urban, midwestern teaching hospital. Ann Intern Med. 1995 Apr 15;122(8):580–585. doi: 10.7326/0003-4819-122-8-199504150-00004. [DOI] [PubMed] [Google Scholar]
  5. Battershill J. H. Cutaneous testing in the elderly patient with tuberculosis. Chest. 1980 Feb;77(2):188–189. doi: 10.1378/chest.77.2.188. [DOI] [PubMed] [Google Scholar]
  6. Berenyi M. R., Straus B., Cruz D. In vitro and in vivo studies of cellular immunity in alcoholic cirrhosis. Am J Dig Dis. 1974 Mar;19(3):199–205. doi: 10.1007/BF01072535. [DOI] [PubMed] [Google Scholar]
  7. Bevilacqua M. P. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol. 1993;11:767–804. doi: 10.1146/annurev.iy.11.040193.004003. [DOI] [PubMed] [Google Scholar]
  8. Gearing A. J., Hemingway I., Pigott R., Hughes J., Rees A. J., Cashman S. J. Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann N Y Acad Sci. 1992 Dec 4;667:324–331. doi: 10.1111/j.1749-6632.1992.tb51633.x. [DOI] [PubMed] [Google Scholar]
  9. Gearing A. J., Newman W. Circulating adhesion molecules in disease. Immunol Today. 1993 Oct;14(10):506–512. doi: 10.1016/0167-5699(93)90267-O. [DOI] [PubMed] [Google Scholar]
  10. Hsu C. C., Leevy C. M. Inhibition of PHA-stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis. Clin Exp Immunol. 1971 May;8(5):749–760. [PMC free article] [PubMed] [Google Scholar]
  11. Pirisi M., Falleti E., Fabris C., Soardo G., Toniutto P., Vitulli D., Pezzetta F., Bortolotti N., Gonano F., Bartoli E. Circulating intercellular adhesion molecule-1 (cICAM-1) concentration in liver disease. Relationship with cholestasis and functioning hepatic mass. Am J Clin Pathol. 1994 Nov;102(5):600–604. doi: 10.1093/ajcp/102.5.600. [DOI] [PubMed] [Google Scholar]
  12. Plusa S., Webster N., Primrose J. Obstructive jaundice causes reduced expression of polymorphonuclear leucocyte adhesion molecules and a depressed response to bacterial wall products in vitro. Gut. 1996 May;38(5):784–787. doi: 10.1136/gut.38.5.784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rothlein R., Mainolfi E. A., Czajkowski M., Marlin S. D. A form of circulating ICAM-1 in human serum. J Immunol. 1991 Dec 1;147(11):3788–3793. [PubMed] [Google Scholar]
  14. Rubin L. A., Nelson D. L. The soluble interleukin-2 receptor: biology, function, and clinical application. Ann Intern Med. 1990 Oct 15;113(8):619–627. doi: 10.7326/0003-4819-113-8-619. [DOI] [PubMed] [Google Scholar]
  15. Swain M. G., Tjandra K., Kanwar S., Kubes P. Neutrophil adhesion is impaired in rat model of cholestasis. Gastroenterology. 1995 Sep;109(3):923–932. doi: 10.1016/0016-5085(95)90403-4. [DOI] [PubMed] [Google Scholar]
  16. Thomas H. C., Singer C. R., Tilney N. L., Folch H., MacSween R. N. The immune response in cirrhotic rats. Antigen distribution, humoral immunity, cell-mediated immunity and splenic suppressor cell activity. Clin Exp Immunol. 1976 Dec;26(3):574–582. [PMC free article] [PubMed] [Google Scholar]
  17. Volpes R., van den Oord J. J., Desmet V. J. Immunohistochemical study of adhesion molecules in liver inflammation. Hepatology. 1990 Jul;12(1):59–65. doi: 10.1002/hep.1840120110. [DOI] [PubMed] [Google Scholar]
  18. Zöhrens G., Armbrust T., Pirzer U., Meyer zum Büschenfelde K. H., Ramadori G. Intercellular adhesion molecule-1 concentration in sera of patients with acute and chronic liver disease: relationship to disease activity and cirrhosis. Hepatology. 1993 Oct;18(4):798–802. doi: 10.1002/hep.1840180408. [DOI] [PubMed] [Google Scholar]

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