Table 4.
Histopathology-Histomorphometry for the Abdominal Fat Pads and Liver in Sham-operated or OVX ddY Mice.
| Items Groups | Abdominal Fat Pads | Hepatic Tissues | ||
|---|---|---|---|---|
| Total Thickness (μm) | Mean Adipocyte Diameters (μm) | Steatosis Regions (%) | Mean Hepatocyte Diameters (μm) | |
| Controls | ||||
| Sham | 1.41 ± 0.45 | 35.05 ± 10.25 | 13.08 ± 3.16 | 9.83 ± 3.34 |
| OVX | 6.04 ± 0.75 * | 129.93 ± 24.06 * | 78.58 ± 6.76 * | 31.93 ± 4.92 * |
| Estradiol | 2.89 ± 0.27 *,# | 67.49 ± 14.77 *,# | 43.43 ± 6.53 *,# | 18.45 ± 3.66 *,# |
| RC | 4.48 ± 0.51 *,# | 92.85 ± 12.70 *,# | 59.42 ± 7.08 *,# | 23.47 ± 3.83 *,# |
| PCP | 4.70 ± 0.63 *,# | 97.27 ± 15.68 *,# | 62.01 ± 7.82 *,# | 23.66 ± 3.59 *,# |
| RC:PCP | ||||
| 1:1 | 3.58 ± 0.49 *,#,†,‡ | 55.57 ± 12.55 *,#,†,‡ | 44.63 ± 6.94 *,#,†,‡ | 16.00 ± 3.73 *,#,†,‡ |
| 1:2 | 4.59 ± 0.45 *,# | 88.91 ± 15.64 *,# | 58.37 ± 7.54 *,# | 22.28 ± 4.15 *,# |
| 1:4 | 4.55 ± 0.65 *,# | 89.01 ± 13.89 *,# | 59.80 ± 6.51 *,# | 22.34 ± 2.75 *,# |
| 1:8 | 4.67 ± 0.61 *,# | 95.77 ± 18.09 *,# | 61.13 ± 10.91 *,# | 23.83 ± 2.67 *,# |
| 2:1 | 2.71 ± 0.93 *,#,†,‡ | 47.17 ± 10.84 #,†,‡ | 37.84 ± 9.05 *,#,†,‡ | 14.24 ± 4.07 *,#,†,‡ |
| 4:1 | 3.69 ± 0.50 *,#,†,‡ | 62.87 ± 14.30 *,#,†,‡ | 45.99 ± 8.44 *,#,†,‡ | 17.53 ± 3.43 *,#,†,‡ |
| 8:1 | 4.47 ± 0.75 *,# | 94.54 ± 14.59 *,# | 59.98 ± 7.88 *,# | 23.41 ± 4.31 *,# |
Values are expressed mean ± S.D. of eight mice. * p < 0.05 as compared with sham control; # p < 0.01 as compared with OVX control; † p < 0.05 as compared with RC single formula treated mice; ‡ p < 0.01 as compared with PCP single formula treated mice; OVX = Bilateral ovariectomy; RC = Red clover dry extracts; PCP = Pomegranate Concentrate Powder; RC:PCP = Mixed formulations consisted of RC and PCP (g/g).