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. 1986 Mar;39(3):284–292. doi: 10.1136/jcp.39.3.284

Poorly differentiated squamous carcinoma of the bronchus: a light and electron microscopic study.

A Carlile, C Edwards
PMCID: PMC499764  PMID: 2420833

Abstract

As there is little published information on the ultrastructure of poorly differentiated squamous carcinoma of the bronchus 18 examples of this tumour were studied. On light microscopy 10 of the tumours contained foci of keratinisation or intercellular bridges and therefore fulfilled the World Health Organisation's diagnostic criteria. In eight these features were absent, but the overall appearance was sufficiently squamoid to preclude their placement in any other category. On electron microscopy many cells showed the characteristic desmosomes and tonofilament of of squamous carcinoma, but there were also areas of adenodifferentiation. The ultrastructure of both light microscopic groups was identical. In conclusion, this type of tumour is dimorphic with characteristics of adenocarcinoma and squamous carcinoma on electron microscopy. Keratinisation and bridges are not essential diagnostic criteria: the overall pattern and cellular morphology are more important.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alvarez-Fernández E. Alveolar trapping in pulmonary carcinomas. Diagn Histopathol. 1982 Jan-Mar;5(1):59–64. [PubMed] [Google Scholar]
  2. Coalson J. J., Mohr J. A., Pirtle J. K., Dee A. L., Rhoades E. R. Electron microscopy of neoplasms in the lung with special emphasis on the alveolar cell carcinoma. Am Rev Respir Dis. 1970 Feb;101(2):181–197. doi: 10.1164/arrd.1970.101.2.181. [DOI] [PubMed] [Google Scholar]
  3. Dingemans K. P., Mooi W. J. Ultrastructure of squamous cell carcinoma of the lung. Pathol Annu. 1984;19(Pt 1):249–273. [PubMed] [Google Scholar]
  4. Greene J. G., Brown A. L., Jr, Divertie M. B. Fine structure of squamous cell carcinoma of the lung. Mayo Clin Proc. 1969 Feb;44(2):85–95. [PubMed] [Google Scholar]
  5. HAMPERL H., HELLWEG G. On mucoepidermoid tumors of different sites. Cancer. 1957 Nov-Dec;10(6):1187–1192. doi: 10.1002/1097-0142(195711/12)10:6<1187::aid-cncr2820100615>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  6. Hattori S., Matsuda M., Tateishi R., Terazawa T. Electron microscopic studies on human lung cancer cells. Gan. 1967 Jun;58(3):283–290. [PubMed] [Google Scholar]
  7. Heard B. E., Dewar A. Squamous cell carcinoma of bronchus: polypoid granules and mitochondrial densities found by electron microscopy. Diagn Histopathol. 1982 Jul-Sep;5(3):189–195. [PubMed] [Google Scholar]
  8. Lupulescu A., Boyd C. B. Lung cancer: a transmission and scanning electron microscopic study. Cancer. 1972 Jun;29(6):1530–1538. doi: 10.1002/1097-0142(197206)29:6<1530::aid-cncr2820290617>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  9. Matthews M. J., Mackay B., Lukeman J. The pathology of non-small cell carcinoma of the lung. Semin Oncol. 1983 Mar;10(1):34–55. [PubMed] [Google Scholar]
  10. McDowell E. M., Trump B. F. Pulmonary smell cell carcinoma showing tripartite differentiation in individual cells. Hum Pathol. 1981 Mar;12(3):286–294. doi: 10.1016/s0046-8177(81)80133-5. [DOI] [PubMed] [Google Scholar]
  11. McDowell E. M., Wilson T. S., Trump B. F. Atypical endocrine tumors of the lung. Arch Pathol Lab Med. 1981 Jan;105(1):20–28. [PubMed] [Google Scholar]
  12. Mollo F., Canese M. G., Campobasso O. Human peripheral lung tumours: light and electron microscopic correlation. Br J Cancer. 1973 Feb;27(2):173–182. doi: 10.1038/bjc.1973.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Obiditsch-Mayer I., Breitfellner G. Electron microscopy in cancer of the lung. Cancer. 1968 May;21(5):945–951. doi: 10.1002/1097-0142(196805)21:5<945::aid-cncr2820210519>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  14. Ogata T., Endo K. Clara cell granules of peripheral lung cancers. Cancer. 1984 Oct 15;54(8):1635–1644. doi: 10.1002/1097-0142(19841015)54:8<1635::aid-cncr2820540827>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  15. Razzuk M. A., Race G. J., Lynn J. A., Martin J. A., Urschel H. C., Jr, Paulson D. L. Observations on ultrastructural morphology of bronchogenic carcinoma. J Thorac Cardiovasc Surg. 1970 Apr;59(4):581–587. [PubMed] [Google Scholar]

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