Abstract
Malignant myoepithelioma (myoepithelial carcinoma) of the breast is extremely rare. A case is reported of a 46 year old female with clear cell mammary malignant myoepithelioma that, on histological examination, was glycogen abundant clear cell carcinoma. Immunohistochemically, the clear cells showed myoepithelial differentiation--that is, they were a smooth muscle actin and S100 protein positive. This case shows that glycogen abundant clear cell carcinoma is a variant of malignant myoepithelioma of the breast.
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- Barwick K. W., Kashgarian M., Rosen P. P. "Clear-cell" change within duct and lobular epithelium of the human breast. Pathol Annu. 1982;17(Pt 1):319–328. [PubMed] [Google Scholar]
- Bennett D. C., Peachey L. A., Durbin H., Rudland P. S. A possible mammary stem cell line. Cell. 1978 Sep;15(1):283–298. doi: 10.1016/0092-8674(78)90104-6. [DOI] [PubMed] [Google Scholar]
- Cameron H. M., Hamperl H., Warambo W. Leiomyosarcoma of the breast originating from myothelium (myoepithelium). J Pathol. 1974 Oct;114(2):89–92. doi: 10.1002/path.1711140206. [DOI] [PubMed] [Google Scholar]
- Cartagena N., Jr, Cabello-Inchausti B., Willis I., Poppiti R., Jr Clear cell myoepithelial neoplasm of the breast. Hum Pathol. 1988 Oct;19(10):1239–1243. doi: 10.1016/s0046-8177(88)80159-x. [DOI] [PubMed] [Google Scholar]
- Chen P. C., Chen C. K., Nicastri A. D., Wait R. B. Myoepithelial carcinoma of the breast with distant metastasis and accompanied by adenomyoepitheliomas. Histopathology. 1994 Jun;24(6):543–548. doi: 10.1111/j.1365-2559.1994.tb00573.x. [DOI] [PubMed] [Google Scholar]
- Eusebi V., Casadei G. P., Bussolati G., Azzopardi J. G. Adenomyoepithelioma of the breast with a distinctive type of apocrine adenosis. Histopathology. 1987 Mar;11(3):305–315. doi: 10.1111/j.1365-2559.1987.tb02635.x. [DOI] [PubMed] [Google Scholar]
- Hull M. T., Warfel K. A. Glycogen-rich clear cell carcinomas of the breast. A clinicopathologic and ultrastructural study. Am J Surg Pathol. 1986 Aug;10(8):553–559. doi: 10.1097/00000478-198608000-00005. [DOI] [PubMed] [Google Scholar]
- Merino M. J., Livolsi V. A. Signet ring carcinoma of the female breast: a clinicopathologic analysis of 24 cases. Cancer. 1981 Oct 15;48(8):1830–1837. doi: 10.1002/1097-0142(19811015)48:8<1830::aid-cncr2820480821>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Oberman H. A. Secretory carcinoma of the breast in adults. Am J Surg Pathol. 1980 Oct;4(5):465–470. doi: 10.1097/00000478-198010000-00006. [DOI] [PubMed] [Google Scholar]
- Ramos C. V., Taylor H. B. Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. Cancer. 1974 Mar;33(3):812–819. doi: 10.1002/1097-0142(197403)33:3<812::aid-cncr2820330328>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- Saksela E., Tarkkanen J., Wartiovaara J. Parotid clear-cell adenoma of possible myoepithelial origin. Cancer. 1972 Sep;30(3):742–748. doi: 10.1002/1097-0142(197209)30:3<742::aid-cncr2820300323>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
- Schürch W., Potvin C., Seemayer T. A. Malignant myoepithelioma (myoepithelial carcinoma) of the breast: an ultrastructural and immunocytochemical study. Ultrastruct Pathol. 1985;8(1):1–11. doi: 10.3109/01913128509141504. [DOI] [PubMed] [Google Scholar]
- Soares J., Tomasic G., Bucciarelli E., Eusebi V. Intralobular growth of myoepithelial cell carcinoma of the breast. Virchows Arch. 1994;425(2):205–210. doi: 10.1007/BF00230358. [DOI] [PubMed] [Google Scholar]
- Tamai M. Intraductal growth of malignant mammary myoepithelioma. Am J Surg Pathol. 1992 Nov;16(11):1116–1125. doi: 10.1097/00000478-199211000-00011. [DOI] [PubMed] [Google Scholar]
- Tavassoli F. A. Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol. 1991 Jun;15(6):554–568. doi: 10.1097/00000478-199106000-00004. [DOI] [PubMed] [Google Scholar]




