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. 1997 Sep;50(9):769–770. doi: 10.1136/jcp.50.9.769

Helicobacter pylori does not release cysteamine into gastric juice.

M B Leonard 1, W D Neithercut 1, D Gillen 1, K E McColl 1
PMCID: PMC500175  PMID: 9389979

Abstract

AIM: To determine whether Helicobacter pylori releases cysteamine into gastric juice as cysteamine is known to be ulcerogenic. METHODS: Samples of fasting gastric juice were collected from 22 individuals (four women); 10 subjects were H pylori negative. The presence of infection was confirmed by examination and culture of gastric biopsies. Cysteamine in gastric juice was measured by reversed phase gradient high performance liquid chromatography with a detection limit of 10 mumol/l. RESULTS: Cysteamine was not detected in any of the gastric juice samples or in extracts of cultured H pylori. CONCLUSIONS: If H pylori produces cysteamine then the amounts produced are insignificant and are unlikely to explain the association between H pylori infection and the development of duodenal ulcer disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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