Abstract
AIMS: To clarify a clinical entity of juvenile polyposis of the stomach compared with generalised juvenile gastrointestinal polyposis. METHODS: The clinicopathological features of juvenile polyposis dominantly involving the stomach at initial presentation were reviewed in 12 patients (three new patients and nine from the literature). These were compared with 29 cases of generalised juvenile gastrointestinal polyposis. RESULTS: There were three men and nine women with juvenile polyposis of the stomach, aged 10-63 years. Hypoproteinaemia was present in nine patients, anaemia in seven, and a family history of intestinal polyposis in seven. No patient presented with a congenital abnormality. During the observation period, two patients developed colonic juvenile polyps. Gastric polyps invariably affected the antrum and extended to the fundus, eventually becoming more numerous, larger, and more pedunculated. Ten patients required gastrectomy for associated malignancy or uncontrolled protein losing gastropathy. Histological examinations of the resected specimens demonstrated neoplastic tissue arising from juvenile polyps in four of the 12 patients. Atypism in these mixed polyps varied from adenoma to well or moderately differentiated adenocarcinoma. CONCLUSIONS: Juvenile polyposis of the stomach has malignant potential, and may be a separate entity from generalised juvenile gastrointestinal polyposis.
Full text
PDF



Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Desai D. C., Neale K. F., Talbot I. C., Hodgson S. V., Phillips R. K. Juvenile polyposis. Br J Surg. 1995 Jan;82(1):14–17. doi: 10.1002/bjs.1800820106. [DOI] [PubMed] [Google Scholar]
- Höfting I., Pott G., Schrameyer B., Stolte M. Familiäre Juvenile Polyposis mit vorwiegender Magenbeteiligung. Z Gastroenterol. 1993 Sep;31(9):480–483. [PubMed] [Google Scholar]
- Jass J. R., Williams C. B., Bussey H. J., Morson B. C. Juvenile polyposis--a precancerous condition. Histopathology. 1988 Dec;13(6):619–630. doi: 10.1111/j.1365-2559.1988.tb02093.x. [DOI] [PubMed] [Google Scholar]
- Leggett B. A., Thomas L. R., Knight N., Healey S., Chenevix-Trench G., Searle J. Exclusion of APC and MCC as the gene defect in one family with familial juvenile polyposis. Gastroenterology. 1993 Nov;105(5):1313–1316. doi: 10.1016/0016-5085(93)90134-x. [DOI] [PubMed] [Google Scholar]
- MCCOLL I., BUSXEY H. J., VEALE A. M., MORSON B. C. JUVENILE POLYPOSIS COLI. Proc R Soc Med. 1964 Oct;57:896–897. [PubMed] [Google Scholar]
- Morimoto Y., Nakao Y., Nagahara A., Tomoda J., Watanabe A., Nagashima H., Kin H., Mimura H., Tomoi M. [Case report of familial juvenile polyposis of the stomach associated with gastrointestinal malignancy]. Nihon Shokakibyo Gakkai Zasshi. 1986 Jul;83(7):1376–1381. [PubMed] [Google Scholar]
- Sachatello C. R., Hahn I. S., Carrington C. B. Juvenile gastrointestinal polyposis in a female infant: report of a case and review of the literature of a recently recognized syndrome. Surgery. 1974 Jan;75(1):107–114. [PubMed] [Google Scholar]
- Sachatello C. R., Pickren J. W., Grace J. T., Jr Generalized juvenile gastrointestinal polyposis. A hereditary syndrome. Gastroenterology. 1970 May;58(5):699–708. [PubMed] [Google Scholar]
- Sassatelli R., Bertoni G., Serra L., Bedogni G., Ponz de Leon M. Generalized juvenile polyposis with mixed pattern and gastric cancer. Gastroenterology. 1993 Mar;104(3):910–915. doi: 10.1016/0016-5085(93)91031-c. [DOI] [PubMed] [Google Scholar]
- Stemper T. J., Kent T. H., Summers R. W. Juvenile polyposis and gastrointestinal carcinoma. A study of a kindred. Ann Intern Med. 1975 Nov;83(5):639–646. doi: 10.7326/0003-4819-83-5-639. [DOI] [PubMed] [Google Scholar]
- Subramony C., Scott-Conner C. E., Skelton D., Hall T. J. Familial juvenile polyposis. Study of a kindred: evolution of polyps and relationship to gastrointestinal carcinoma. Am J Clin Pathol. 1994 Jul;102(1):91–97. doi: 10.1093/ajcp/102.1.91. [DOI] [PubMed] [Google Scholar]
- Watanabe A., Nagashima H., Motoi M., Ogawa K. Familial juvenile polyposis of the stomach. Gastroenterology. 1979 Jul;77(1):148–151. [PubMed] [Google Scholar]