Abstract
Background
Physicians work considerably longer hours and are less satisfied with work-life balance than U.S. workers in other fields. There is, however, minimal data on physicians’ parental satisfaction.
Methods
To evaluate differences in parental satisfaction among physicians and workers in other fields, we surveyed U.S. physicians as well as a probability-based sample of the general U.S. working population between August 2014–October 2014. Parental satisfaction and the perceived impact of career on relationships with children were evaluated.
Results
Among 6880 responding physicians (cooperation rate 19.2 %), 5582 (81.1 %) had children. Overall, physicians were satisfied in their relationships with their children, with 4782 (85.9 %) indicating that they were either very satisfied [n = 2738; (49.2 %)] or satisfied [n = 2044 (36.7 %)]. In contrast, less than half believed their career had made either a major [n = 1212; (21.8 %)] or minor positive [n = 1260; (22.7 %)] impact on their relationship with their children, with a slightly larger proportion indicating a major (n = 2071 [37.2 %]) or minor (n = 501 [9 %]) negative impact. Women physicians were less likely to believe their career had made a positive impact as were younger physicians. Hours worked/week inversely correlated with the belief that career had made a positive impact on relationships with children. Both men (OR: 2.75; p < 0.0001) and women (OR: 4.33; p < 0.0001) physicians were significantly more likely to report that their career had a negative impact on relationships with their children than the sex-matched U.S. working population.
Conclusions
U.S. physicians report generally high satisfaction in their relationships with their children. Despite their high satisfaction, physicians have a more negative perception of the impact of their career on relationships with their children than U.S. workers in general.
Electronic supplementary material
The online version of this article (doi:10.1186/s12909-016-0737-7) contains supplementary material, which is available to authorized users.
Keywords: Physicians, Doctors, Parents, Satisfaction, Children, Career, Work-life integration
Background
Being a physician is a demanding and rewarding endeavor. Physicians undergo long and arduous training, work dramatically more hours than workers in other fields, and are at high risk for professional burnout [1]. As a counterbalance to these factors, physicians engage in intellectually stimulating work, are well compensated relative to many professions, and often develop meaningful and fulfilling relationships with patients [2, 3]. The net effect of these positive and negative forces on each physician is unique and can vary over the course of their career [4–6].
The impact of a career in medicine on physicians’ personal relationships has been a subject of interest in recent years. This dimension has taken on new complexity as the proportion of women physicians and two-physician couples have increased. Despite the stereotypes that physicians neglect their partners and have high divorce rates, recent studies in the U.S. suggest divorce rates among physicians are lower than both the population in general as well as other professionals [7]. Recent studies also suggest high marital satisfaction among spouses/partners of U.S. physicians and indicate that the amount of time spent together each day is the dominant driver of relationship satisfaction among spouses/partners of physicians [8].
While these studies have provided insights regarding the marital satisfaction of physicians, one aspect that has not been well studied is the impact of a career in medicine on physicians’ relationships with their children. The largest study exploring this dimension to date included only 415 physicians, excluded single parents, and was derived from a survey conducted >25 years ago [9]. That study found that physicians were less satisfied in their relationships with their children than their relationships with their spouse, with comparable parental satisfaction among both women and men physicians. On multivariate analysis, greater parental satisfaction was found among physicians less than age 45 and among those whose spouse was supportive of their career, as well as those married to an individual working as a professional or as a homemaker [9]. Physicians working in an employed practice model also had higher parental satisfaction than those working in solo or group practice.
A number of societal shifts have occurred since the time of that study, including an increase in the proportion of physicians who are women, a higher prevalence of single parents and a greater number of adults in two-career relationships [10]. Many changes have also occurred in the practice structure of medicine with a majority of physicians now functioning as employees of large medical organizations [11]. There are no data comparing the parental experience of physicians to that of the general U.S. population. Here we report the results of a large study evaluating the parental satisfaction of U.S. physicians along with comparison to the general U.S. population.
Methods
As previously reported [12], we surveyed a national sample of U.S. physicians from all specialties between August 2014-October 2014 using the AMA’s Physician Master File, a nearly complete record of all physicians in the United States. Participation was voluntary and results were anonymous. In accordance with established methodology, the 35,922 physicians who opened at least one invitation e-mail were considered to have received the invitation to participate in the study [13]. A probability-based sample of employed U.S. adults was also surveyed for comparison to physicians in October 2014. The population survey was conducted using Knowledge Panel®, a probability-based panel designed to be representative of the U.S. population. Participants in the KnowledgePanel® are initially chosen scientifically by a random selection of telephone numbers and residential addresses. Persons in selected households are then invited by telephone or by mail to participate. Additional technical information is available at: http://www.gfk.com/products-a-z/us/knowledgepanelr-north-america/. The Mayo Clinic Institutional Review Board approved this study.
The initial results of this study, including the personal and professional characteristics of participating physicians, assessment of physician well-being (e.g. burnout, symptoms of depression, suicidal ideation, satisfaction with work/life balance, career satisfaction), and comparison of physician well-being to that of working U.S. adults have been previously reported [12].
Parental satisfaction
Participating physicians were asked whether they had any children. Those who indicated they had children were asked the age of their youngest child and questions regarding their parental satisfaction (questions provided in Additional file 1). One item asked physicians to rate their overall satisfaction with the relationship they have with their children (response options: very satisfied, satisfied, neither satisfied nor dissatisfied, dissatisfied, very dissatisfied). The second item asked physicians to rate the impact their career had made on their relationship with their children (response options: major positive impact, minor positive impact, no impact, minor negative impact, major negative impact). These items were formatted to be similar to previously used items evaluating marital satisfaction [1, 8, 9]. The second question was also asked of working U.S. adults.
Statistical analysis
Standard descriptive summary statistics were used to characterize physician and control samples. Associations between variables were evaluated using the Kruskal-Wallis test or Chi Square test as appropriate. All tests were two-sided with Type I error rates of 0.05. Multivariate analysis of differences across specialties was performed using logistic regression. Pooled multivariate logistic regression analysis of physicians with respect to the impact of their career on their relationship with their children was also performed to identify personal and professional factors associated with the dependent variable. For comparisons with population controls, physician data was restricted to responders between the ages of 29 and 65 years of age who were not retired in order to match the age and employment status of the U.S. population sample. All analyses were done using SAS version 9 (SAS Institute, Inc., Cary, North Carolina).
Results
Of the 35,922 physicians who received an invitation to participate, 6880 (19.2 %) completed surveys [12]. Among the 6880 responding physicians, 5582 (81.1 %) indicated that they had children. The personal and professional characteristics of physicians with children, as well as all responding physicians, are shown in Table 1.
Table 1.
Characteristics | 2014 Responders N = 6880 | Parents only N = 5582 |
---|---|---|
Gender | ||
Male | 4497(67.5 %) | 3986 (71.9 %) |
Female | 2162(32.5 %) | 1556 (28.1 %) |
Missing | 221 | 40 |
Age in Years | ||
Median | 56 | 57 |
</= 35 | 466 (7.0 %) | 244 (4.4 %) |
36–45 | 1212 (18.2 %) | 919 (16.6 %) |
46–55 | 1484 (22.3 %) | 1240 (22.4 %) |
56–65 | 2206 (33.1 %) | 1937 (35.0 %) |
>65 | 1289 (19.4 %) | 1201 (21.7 %) |
missing | 223 | 41 |
Relationship Status | ||
Missing | 209 | 32 |
Single | 722 (10.8 %) | 303 (5.5 %) |
Married | 5573 (83.5 %) | 5004 (90.2 %) |
Partnered | 274 (4.1 %) | 156 (2.8 %) |
Widowed | 102 (1.5 %) | 87 (1.6 %) |
Age Youngest Child | ||
<5 | 740 (11.2 %) | 740 (13.3 %) |
5–12 | 873 (13.2 %) | 873 (15.7 %) |
13–18 | 781 (11.8 %) | 781 (14.1 %) |
19–22 | 737 (11.1 %) | 737 (13.3 %) |
22+ | 2420 (36.5 %) | 2420 (43.6 %) |
Missing | 255 | 31 |
Hours Worked Per Week | ||
<40 h | 1172(17.4 %) | 990 (18.1 %) |
40–49 h | 1340(19.9 %) | 1066 (19.5 %) |
50–59 h | 1667(24.7 %) | 1350 (24.6 %) |
60–69 h | 1526(22.6 %) | 1238 (22.6 %) |
70–79 h | 535(7.9 %) | 436 (8.0 %) |
≥80 h | 509(7.5 %) | 399 (7.3 %) |
Missing | 131 | 103 |
# Nights on Call Per Week | ||
Median(IQR) | 1(0–3) | 1 (0–3) |
Primary Practice Setting | ||
Private practice | 3605(52.6 %) | 3048 (54.8 %) |
Academic Medical Center | 1625(23.7 %) | 1251 (22.5 %) |
Veterans hospital | 104(1.5 %) | 74 (1.3 %) |
Active military practice | 58(0.8 %) | 37 (0.7 %) |
Not in practice or retired | 160(2.3 %) | 136 (2.4 %) |
Other | 1303(19 %) | 1020 (18.3 %) |
Missing | 205 | 16 |
Level of satisfaction relationship with children | ||
Very satisfied | 2738 (49.2 %) | |
Satisfied | 2044 (36.7 %) | |
Neither satisfied/dissatisfied | 341 (6.1 %) | |
Dissatisfied | 372 (6.7 %) | |
Very dissatisfied | 73 (1.3 %) | |
No children/missing | 14 | |
Impact of career on relationship with children | ||
Major positive impact | 1212 (21.8 %) | |
Minor positive impact | 1260 (22.7 %) | |
No impact | 517 (9.3 %) | |
Minor negative impact | 2071 (37.2 %) | |
Major negative impact | 501 (9.0 %) | |
No children/missing | 21 |
Parental satisfaction of U.S. physicians
Overall, physicians were satisfied in their relationships with their children, with 4782 (85.9 %) indicating that they were either very satisfied [n = 2738; (49.2 %)] or satisfied [n = 2044; (36.7 %)]. Slightly less than half of physicians believed their career had made either a major positive [n = 1212; (21.8 %)] or a minor positive [n = 1260; (22.7 %)] impact on their relationships with their children, while fewer believed their career had made a minor [n = 2071; (37.2 %)] or major negative [501; (9 %)] impact, respectively.
Small differences in satisfaction in relationships with their children were observed by gender, age, hours worked/week, nights on call/week, specialty, practice setting, or method of compensation (Additional file 1 Figure S1). Larger associations were observed between these personal and professional characteristics and physicians’ perception of the impact of their career on relationships with their children (Fig. 1a-f). Women physicians were more likely to report a negative impact of their career on relationships with their children than their male colleagues (women: 51.7 % vs. men: 41.1 %; p ˂ 0.001; Fig. 1a). Younger physicians were also less likely to believe their career had made a positive impact than their older colleagues (Fig. 1b). Physicians whose relationship status was single or partnered were less likely to be satisfied than those who were married (Fig. 1c). Hours worked/week inversely correlated with the belief that career had made a positive impact on relationships with their children, with an apparent dose effect (Fig. 1d). Those in a salary-plus-bonus model were less likely to believe their career had made a positive impact on relationships with their children than those in either a pure salaried position or a pure incentive-based system (Fig. 1e).
The association between specialty and practice setting and physicians’ belief that their career had made a positive impact on relationships with their children is shown in Fig. 1f and g. Specialties least likely to believe that their career had made a positive impact on relationships with their children included obstetrics and gynecology, internal medicine subspecialties, and anesthesiology, while those most likely to believe that their career had made a positive impact included ophthalmologists, general pediatricians, and psychiatrists.
The results of multivariate analysis including the variables age, gender, relationship status, hours/week, specialty, practice setting, and method of compensation are shown in Table 2. Women physicians and physicians who were older were more likely to be satisfied in their relationships with their children. Physicians whose relationship status was single or partnered were less likely to be satisfied than those who were married. Physicians who were in an academic or “other” practice setting were more likely to be satisfied than those in private practice, while those who were not in practice or retired were less likely to be satisfied. Physicians in a salaried model were less likely to be satisfied in their relationship with their children than those in a pure incentive-based compensation model. Hours worked/week also remained strongly associated with parental satisfaction in the multivariate analysis, where each additional hour worked/week reduced the likelihood of satisfaction by 1 %.
Table 2.
Variable | OR (95 % CI) | P |
---|---|---|
Age (for each year older) | 1.01 (1.00–1.02) | 0.0070 |
Female (vs. Male) | 1.29 (1.07–1.56) | 0.0089 |
Partnered (vs. Married) | 0.46 (0.31–0.68) | 0.0001 |
Single (vs. Married) | 0.60 (0.46–0.77) | <0.0001 |
Academic practice vs. private practice | 1.50 (1.20–1.88) | 0.0004 |
Not in practice/retired (vs. private practice) | 0.54 (0.31–0.94) | 0.0293 |
Other practice setting (vs. private practice) | 1.31 (1.04–1.66) | 0.0244 |
Salaried w no incentive pay (vs. incentive pay only) | 0.72 (0.58–0.90) | 0.0036 |
Hours worked per week (for each additional hour) | 0.99 (0.98–0.99) | <0.0001 |
Factors in model: age, gender, relationship status, hours/week, specialty, practice setting, method of compensation
We also conducted a multivariate analysis including the same variables to identify factors associated with physicians’ perception that their career had made a positive impact on relationships with their children (Table 3). Increasing age (odds ratio [OR] = 1.039 [95 % confidence interval [CI]: 1.034-1.045]; p ˂ 0.0001) was associated with an increased likelihood of viewing career as a positive influence, while the number of hours worked/week (OR = 0.990 [95 % CI: 0.986-0.993]; p ˂ 0.0001) was inversely associated with the perception that career had made a positive impact. Physicians whose relationship status was single or partnered were less likely to view their career as a positive influence on relationship with children than those who were married. Physicians who specialized in general pediatrics and ophthalmology were more likely to believe that their career had made a positive impact than those in family medicine (used as the reference specialty).
Table 3.
Variable | OR (95 % CI) | P |
---|---|---|
Age (for each year older) | 1.039 (1.034–1.045) | <0.0001 |
Partnered (vs. Married) | 0.693 (0.485–0.989) | 0.0436 |
Single (vs. Married) | 0.596 (0.461–0.769) | <0.0001 |
Hours worked per week (for each additional hour) | 0.990 (0.986–0.993) | <0.0001 |
General Pediatrics as specialty (vs. Family Med) | 1.657 (1.213–2.264) | 0.0015 |
Ophthalmology as specialty (vs. Family Med) | 1.432 (1.000–2.048) | 0.0497 |
Factors in model: age, gender, relationship status, hours/week, specialty, practice setting, compensation
Physicians compared to U.S. working population
Next, we compared perceptions of the impact of career on relationships with children among physicians to the general U.S. working population (n = 3991; 74.2 %). Both men (physician 48.7 %; population 25.3 %; OR = 2.795 [95 % CI: 2.474-3.157]; p ˂ 0.001) and women (physician 54.0 %; population 21.3 %; OR = 4.327 [95 % CI: 3.715-5.041]; p ˂ 0.001) physicians were significantly more likely to report that their career had a negative impact on relationships with their children than U.S. workers (Fig. 2a). The strong relationship between increasing age and the perception that career had a positive impact on relationships with children was of greater magnitude among physicians than the general population for both men and women (Fig. 2b). Although the proportion of men and women physicians who believed that career had a positive impact on their relationships with children was lower for physicians than the age and sex-matched general population 45 and younger, it was similar to or higher than the age-matched general population for those age 46–65.
In the pooled (physicians and U.S. workers) multivariate analysis, the relationship between advancing age and a more favorable view of the impact of career on relationship with children persisted, as did the inverse association with hours worked/week. Single parents were less likely to view their career as a positive influence on relationship with children than those who were married. The effect of education on the perceived impact of career suggested a beneficial effect to higher levels of education. When compared to individuals who were high school graduates, a stepwise effect on likelihood of satisfaction was observed among individuals with an associate’s degree, bachelor’s degree, master’s degree, or professional/doctoral degree in a field other than medicine (i.e. greater likelihood of satisfaction with higher educational attainment). The beneficial effects of education also held true for physicians relative to high school graduates; however, the effect size of a doctoral degree in medicine degree appeared roughly equivalent to that of a bachelor’s degree, and was lower than that observed with a master’s degree or a professional/doctoral degree in a field outside medicine (Table 4).
Table 4.
Variable | OR (95 % CI) | P |
---|---|---|
Age (for each year older) | 1.026 (1.021–1.031) | <0.0001 |
Hours worked per week (for each additional hour) | 0.986 (0.983–0.989) | <0.001 |
Single (vs. Married) | 0.702 (0.601–0.820) | <0.0001 |
Some college, no degree (vs. High School Graduate) | 1.394 (1.131–1.717) | 0.0018 |
Associates Degree (vs. High School Graduate) | 1.581 (1.247–2.004) | 0.0002 |
Bachelors Degree (vs. High School Graduate) | 2.144 (1.759–2.613) | <0.0001 |
Masters Degree (vs. High School Graduate) | 2.570 (2.040–3.238) | <0.0001 |
Professional/Doctorate Degree (vs. High School Graduate) | 2.868 (2.068–3.976) | <0.0001 |
Physicians (vs. High School Graduate) | 2.117 (1.787–2.508) | <0.0001 |
Factors in model: age, gender, hours/week, relationship status, highest level of education
Discussion
There is minimal information available regarding physicians’ parental satisfaction and perception of the impact of their career on their children. To our knowledge, this is the first national study to assess physicians’ parental satisfaction in the last 25 years, and the only study to evaluate a comparison cohort of working adults from the general U.S. population. Generally, physicians reported high levels of parental satisfaction. Despite the high satisfaction with their relationships with their children, nearly half of physicians reported their career had adversely impacted those relationships. Not surprisingly, hours worked/week had an inverse relationship with the likelihood of perceiving that career had a positive impact. Although women physicians were more likely to report a negative impact of career on relationship with children in univariate analysis, this difference did not persist on multivariate analysis adjusting for age and other factors. Collectively, these results suggest that, while physicians view their career as a potential barrier to the relationships they desire to have with their children, most are satisfied with relationships they develop nonetheless.
Both men and women physicians were dramatically more likely than U.S. workers in general to believe their career had a negative impact on their relationship with their children. Physicians also had a more polarized view of the impact of their career than U.S. workers; <10 % of physicians reported their career had “no impact” on their relationship with their children as compared to 35 %-40 % of U.S. workers. Notably, in multivariate analysis of both physicians and U.S. workers, advancing age was associated with a higher likelihood of viewing career as having a positive impact, while the number of hours worked/week had an inverse association with the perceived impact of career on relationships with children. We are unable to determine the potential reason for this association with age given the cross-sectional nature of the study. A variety of factors may contribute to the more favorable view of the impact of career on parenting with age including: i) a generational effect, ii) a change in the perceived impact of career for those having children later, iii) a change in perception of the impact of career on parenting as the parent and children get older, iv) differences in role conflict over the course of a career, and v) other unmeasured interacting variables factors (e.g. whether the individual is in a two career relationship and the professional characteristics of their partner).
In both physicians and workers in other fields, the highest level of education achieved was also related to the perceived impact of career on relationships with children independent of gender. Relative to high school graduates, a stepwise greater likelihood of reporting that career had a positive impact was observed for those with an associate’s degree, bachelor’s degree, master’s degree, and professional/doctoral degree in a field other than medicine. In contrast to this clear stepwise, incremental association between level of education and the perception that career had made a positive impact among non-physicians, the magnitude of effect of doctoral degree in medicine was more similar to that of a bachelor’s degree and lower than a master’s or professional/doctoral degree in other fields.
Collectively, these findings regarding the relationship between work hours, age and level of education with parental satisfaction are thought provoking, particularly for women. They may argue against the notion that pursuing an advanced or professional degree has an adverse impact on relationship with children and may also suggest that the perceived impact of career on relationships with children becomes more favorable with age. The multivariate analyses of physicians also provide some potential insights for physicians attempting to mitigate a negative effect of their career on their relationships with their children and seeking to cultivate parental satisfaction. First, they suggest that these individuals be acutely aware of the total number of hours worked more so than other variables. Second, for the most part, specialty is irrelevant with respect to satisfaction in relationship with children. Third, practice setting does appear to be related to satisfaction in relationship with children (higher for those in academic practice settings than private practice) but not impact of career on relationship with children. At a minimum, it would seem physician parents need to rigorously monitor work hours, periodically evaluate if they are spending too much time at work, and make sure their specialty and practice setting allow them adequate flexibility to tailor work hours to meet both personal and professional priorities. In this regard, it should be noted that reducing professional work hours may be a helpful strategy for many physicians [14–17], and that the available evidence suggests that working part time does not adversely impact quality of care [8, 9] or patient satisfaction [15, 18–21].
How do these results relate to previous reports? In 1988, Warde and colleagues surveyed 656 married physicians with children in southern California (single parents excluded) [9]. Parental satisfaction among physicians was somewhat lower than marital satisfaction in this cohort. Lower parental satisfaction was observed among older physicians and those experiencing greater “role conflict”, defined as “frustration with the competing demands of career, marriage, and family”. A second report from this cohort indicated greater role conflict was present among women physicians and younger physicians [22]. Among physicians younger than 45, 51 % of men and 87 % of women reported they had made career changes for their children. The most common career changes reported were decreasing work hours, a change in practice type, and interrupting career for their children [22]. More recent studies have also found work-home conflicts and how they are resolved to be powerful contributors to physician burnout [23–25].
Childrearing can be particularly challenging for women physicians due to cultural and societal parenting expectations [26–28]. In 1988, Levinson and colleagues reported the results of a seminal study of 862 women physicians working as faculty members of academic internal medicine practices who were under the age of 50 [29]. They found women physicians were more likely to delay childbearing compared to U.S. women and took relatively short maternity leaves [29]. Collectively, 87 % of academic women physicians reported that they relied on a paid employee to assist in the care of their children, and 68 % reported childrearing had slowed their career progress [29]. At the time of this study, few institutions provided job-sharing opportunities for these faculty members. Although a variety of initiatives to address some of these challenges specific to women physicians have been reported or proposed in recent years [30–33], much more progress is needed given the rapidly growing number of women physicians.
Our study is subject to a number of limitations. First, approximately one in five of physicians surveyed responded. As previously reported, the demographic characteristics of responders were generally consistent with U.S. physicians overall [12]. Nonetheless, how representative participants are of all physicians is unknown. Second, our data are cross-sectional in nature, and we are unable to assess longitudinal changes over time. Third, a number of variables that may interact with parental satisfaction (e.g. characteristics of partner and their career, marital discord, access to family support, access and affordability of day care) were not assessed. Fourth, the study describes the experience of physicians in the U.S. and its generalizability of physicians in other countries is unknown. Finally, although they are similar to previous questions evaluating parental satisfaction in other studies of physicians, the questions we used to evaluate parental satisfaction are not standardized instruments. The fact that we collected simultaneous information using one of these items in a sample of the general U.S. working population for comparison may, to some extent, mitigate this limitation.
Our study also has a number of important strengths. Participants in this study represent a large and diverse sample of U.S. physicians from all specialties and practice types. Unlike previous studies [9, 29], we did not limit the sample to physicians of a single gender, specialty, or practice setting, and we did not exclude single parents. The comparison of physicians to the general U.S. working population is also a unique contribution of this study.
Conclusions
U.S. physicians report generally high satisfaction in their relationships with their children. Despite their high satisfaction, physicians have a more negative perception regarding the impact of their career on relationships with their children than other U.S. workers. The number of hours worked/week and specialty choice were strongly associated with the perceived impact of physicians’ career on their relationships with their children. Additional studies evaluating how physicians can promote healthy relationships with their children and the characteristics of the practice environment that facilitate healthy relationships would be useful.
Acknowledgements
None.
Funding
Funding for this study was provided by the Mayo Clinic Program on Physician Well-being.
Availability of data and materials
data is shared property of the American Medical Association and Mayo Clinic and will not be made public at this time because continued analysis is ongoing.
Authors’ contributions
Concept and design: TS, OH, CW, LD. Acquisition of data and interpretation: TS, OH, SH, CS, DS, JS, CW, LD. Drafting and critical revising the manuscript: TS, OH, SH, CS, DS, JS, CW, LD. Final approval of the manuscript: TS, OH, SH, CS, DS, JS, CW, LD. All authors read and approved the final manuscript.
Competing interest
The authors declare they have no competing interests.
Consent for publication
not applicable.
Ethics approval and consent to participate
The Mayo Clinic Institutional Review Board reviewed and approved the study. Participation was elective and all results anonymous. As approved by the Institutional Review Board reviewed consent was implied by completion of the survey.
Abbreviations
- CI
Confidence interval
- OR
Odds ratio
- US
United States
Additional file
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Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Data Availability Statement
data is shared property of the American Medical Association and Mayo Clinic and will not be made public at this time because continued analysis is ongoing.