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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Gastroenterology. 2016 Jun 16;151(3):540–553.e14. doi: 10.1053/j.gastro.2016.06.005

Figure 2. Overexpression of Etv1 in KPfCY -cells significantly increases liver metastasis (A-D).

Figure 2

Types of liver metastases observed in Etv1 overexpressing tumors including Isolated Tumor Cells (A), tumor microthrombi (B), micrometastasis (C), & macrometastasis (D). (C) Metastases demonstrate stromal expansion reminiscent of primary Etv1 overexpressing tumors (right panel expanded from white box in lower magnification). (E) Matched H&E and immunofluorescence staining for YFP (green) of liver metastasis of Etv1 overexpressing KPfCY tumors. (F) The number of animals with liver metastatic events is significantly higher among Etv1 overexpressing tumors. In addition, Etv1 overexpression was associated with a significantly larger number of total metastatic events of all subtypes pictured in (A-D).