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. 1997 Oct;50(10):863–866. doi: 10.1136/jcp.50.10.863

Expression of tenascin in lymphocytic autoimmune thyroiditis.

W Back 1, C Heubner 1, J Winter 1, U Bleyl 1
PMCID: PMC500271  PMID: 9462272

Abstract

AIMS: To study the distribution of tenascin by immunocytochemistry in autoimmune diseases of the thyroid. METHODS: Thyroids from patients with inflammatory lesions of the thyroid (lymphocytic thyroiditis Hashimoto, Grave's disease, thyroiditis DeQuervain) were studied by immunocytochemistry using antibodies against tenascin, collagen III, and collagen IV. RESULTS: In autoimmune lymphocytic thyroiditis Hashimoto there was a characteristic corona-like staining pattern of tenascin around all activated lymph follicles with germinal centres. This staining pattern contrasted with the immunoreactions for collagen III and IV, which were not enhanced in the perilymphofollicular interstitium. In cases of thyroiditis DeQuervain the areas of early and ongoing fibrosis showed some diffuse staining for tenascin and for collagen III. Enhanced diffuse immunostaining for collagen IV in the perivascular and interfollicular interstitium was present in cases of Grave's disease. In Grave's disease no characteristic immunoreaction was detectable for tenascin. CONCLUSIONS: The corona-like expression of tenascin around lymphofollicular infiltrates is distinctive of cases of lymphocytic thyroiditis. A similar staining pattern for tenascin has been reported in lymphoid hyperplasia of the thymus associated with myasthenia gravis, another autoimmunological disorder. There are good arguments that the activation and infiltration of lymph follicles in the thyroid during the course of autoimmune diseases lead to stimulation and activation of the surrounding mesenchyme producing tenascin as part of the extracellular matrix.

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Selected References

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  1. Andersson J., Abrams J., Björk L., Funa K., Litton M., Agren K., Andersson U. Concomitant in vivo production of 19 different cytokines in human tonsils. Immunology. 1994 Sep;83(1):16–24. [PMC free article] [PubMed] [Google Scholar]
  2. Aufderheide E., Ekblom P. Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions. J Cell Biol. 1988 Dec;107(6 Pt 1):2341–2349. doi: 10.1083/jcb.107.6.2341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Back W., Heubner C. Tenascinexpression im aktivierten lymphatischen Gewebe der Schilddrüse und des Gastrointestinaltrakts. Verh Dtsch Ges Pathol. 1996;80:326–326. [PubMed] [Google Scholar]
  4. Chilosi M., Lestani M., Benedetti A., Montagna L., Pedron S., Scarpa A., Menestrina F., Hirohashi S., Pizzolo G., Semenzato G. Constitutive expression of tenascin in T-dependent zones of human lymphoid tissues. Am J Pathol. 1993 Nov;143(5):1348–1355. [PMC free article] [PubMed] [Google Scholar]
  5. Chiquet-Ehrismann R., Mackie E. J., Pearson C. A., Sakakura T. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell. 1986 Oct 10;47(1):131–139. doi: 10.1016/0092-8674(86)90374-0. [DOI] [PubMed] [Google Scholar]
  6. Erickson H. P. Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. Curr Opin Cell Biol. 1993 Oct;5(5):869–876. doi: 10.1016/0955-0674(93)90037-q. [DOI] [PubMed] [Google Scholar]
  7. Götz B., Scholze A., Clement A., Joester A., Schütte K., Wigger F., Frank R., Spiess E., Ekblom P., Faissner A. Tenascin-C contains distinct adhesive, anti-adhesive, and neurite outgrowth promoting sites for neurons. J Cell Biol. 1996 Feb;132(4):681–699. doi: 10.1083/jcb.132.4.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Liakka K. A., Autio-Harmainen H. I. Distribution of the extracellular matrix proteins tenascin, fibronectin, and vitronectin in fetal, infant, and adult human spleens. J Histochem Cytochem. 1992 Aug;40(8):1203–1210. doi: 10.1177/40.8.1377736. [DOI] [PubMed] [Google Scholar]
  9. Mitchell J. D., Kirkham N., Machin D. Focal lymphocytic thyroiditis in Southampton. J Pathol. 1984 Dec;144(4):269–273. doi: 10.1002/path.1711440408. [DOI] [PubMed] [Google Scholar]
  10. Pearson C. A., Pearson D., Shibahara S., Hofsteenge J., Chiquet-Ehrismann R. Tenascin: cDNA cloning and induction by TGF-beta. EMBO J. 1988 Oct;7(10):2977–2982. doi: 10.1002/j.1460-2075.1988.tb03160.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Riedl S. E., Faissner A., Schlag P., Von Herbay A., Koretz K., Möller P. Altered content and distribution of tenascin in colitis, colon adenoma, and colorectal carcinoma. Gastroenterology. 1992 Aug;103(2):400–406. doi: 10.1016/0016-5085(92)90827-l. [DOI] [PubMed] [Google Scholar]
  12. Rutherford W. H. Sequelae of concussion caused by minor head injuries. Lancet. 1977 Jan 1;1(8001):1–4. doi: 10.1016/s0140-6736(77)91649-x. [DOI] [PubMed] [Google Scholar]
  13. Rüegg C. R., Chiquet-Ehrismann R., Alkan S. S. Tenascin, an extracellular matrix protein, exerts immunomodulatory activities. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7437–7441. doi: 10.1073/pnas.86.19.7437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schalkwijk J., Steijlen P. M., van Vlijmen-Willems I. M., Oosterling B., Mackie E. J., Verstraeten A. A. Tenascin expression in human dermis is related to epidermal proliferation. Am J Pathol. 1991 Nov;139(5):1143–1150. [PMC free article] [PubMed] [Google Scholar]
  15. Schröder S., Arndt R., Weinland G., Schuppert F. Morphologie und Klinik der Immunthyreopathien. Pathologe. 1996 Jul;17(4):276–288. doi: 10.1007/s002920050166. [DOI] [PubMed] [Google Scholar]
  16. Soini Y., Alavaikko M., Lehto V. P., Virtanen I. Tenascin in reactive lymph nodes and in malignant lymphomas. Pathol Res Pract. 1992 Dec;188(8):1078–1082. doi: 10.1016/S0344-0338(11)81254-9. [DOI] [PubMed] [Google Scholar]
  17. WILLIAMS E. D., DONIACH I. The post-mortem incidence of focal thyroiditis. J Pathol Bacteriol. 1962 Jan;83:255–264. doi: 10.1002/path.1700830127. [DOI] [PubMed] [Google Scholar]

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