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. 1996 Feb;49(2):120–123. doi: 10.1136/jcp.49.2.120

Lipoproteins in pregnant women before and during delivery: influence on neonatal haemorheology.

J Uberos-Fernández 1, A Muñoz-Hoyos 1, A Molina-Carballo 1, A Puertas-Prieto 1, A Valenzuela-Ruiz 1, C Ruiz-Cosano 1, J A Molina-Font 1
PMCID: PMC500343  PMID: 8655676

Abstract

AIMS: To investigate whether the lipid profile of pregnant women during parturition differs from the profile at previous stages of pregnancy and to determine the effects of maternal lipid changes on fetal or neonatal haemorheology. METHODS: Sixty pregnant women were studied, divided into two groups. Group 1 contained 30 women of mean age of 27 (SD 3) years and gestational age > 38 weeks in whom delivery had not yet begun; all these pregnancies followed an uncomplicated course and there was no evidence of any fetal pathology from previous obstetric examinations. All the women reached term and birth weight was 3340 (350) g. Group 2 contained women of mean age 26 (4) years, in whom delivery was ongoing, all of whose pregnancies reached term. The following variables were determined in all cases: total cholesterol, triglycerides, high density lipoproteins (HDL), low density lipoproteins (LDL), free fatty acids and phospholipids, and apoprotein A (apo-A) and apoprotein B (apo-B). Serum and plasma viscosity was measured with a capillary viscosimeter. RESULTS: The apo-B/apo-A and HDL/apo-A ratios increased during delivery, indicating that in pregnant women these atherogenic indices are raised during delivery compared with previous gestational stages. Significant correlation coefficients were obtained between maternal lipids (triglycerides, total cholesterol, LDL, total cholesterol/HDL, and LDL/HDL) and plasma viscosity in the neonate. CONCLUSIONS: Plasma atherogenic indices increase progressively until birth. These changes have implications for neonatal haemorheology because they cause an increase in plasma viscosity.

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Selected References

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  1. Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
  2. Black V. D. Neonatal hyperviscosity syndromes. Curr Probl Pediatr. 1987 Feb;17(2):73–130. doi: 10.1016/0045-9380(87)90033-8. [DOI] [PubMed] [Google Scholar]
  3. Darmady J. M., Postle A. D. Lipid metabolism in pregnancy. Br J Obstet Gynaecol. 1982 Mar;89(3):211–215. doi: 10.1111/j.1471-0528.1982.tb03616.x. [DOI] [PubMed] [Google Scholar]
  4. Ernst E., Resch K. L., Saradeth T., Maier A., Matrai A. A viscometric method of measuring plasma fibrinogen concentrations. J Clin Pathol. 1992 Jun;45(6):534–535. doi: 10.1136/jcp.45.6.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502. [PubMed] [Google Scholar]
  6. Fåhraeus L., Larsson-Cohn U., Wallentin L. Plasma lipoproteins including high density lipoprotein subfractions during normal pregnancy. Obstet Gynecol. 1985 Oct;66(4):468–472. [PubMed] [Google Scholar]
  7. Jimenez D. M., Pocovi M., Ramon-Cajal J., Romero M. A., Martinez H., Grande F. Longitudinal study of plasma lipids and lipoprotein cholesterol in normal pregnancy and puerperium. Gynecol Obstet Invest. 1988;25(3):158–164. doi: 10.1159/000293765. [DOI] [PubMed] [Google Scholar]
  8. Lopes-Virella M. F., Stone P., Ellis S., Colwell J. A. Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem. 1977 May;23(5):882–884. [PubMed] [Google Scholar]
  9. Muñoz A., Uberos J., Molina A., Valenzuela A., Cano D., Ruiz C., Molina Font J. A. Relationship of blood rheology to lipoprotein profile during normal pregnancies and those with intrauterine growth retardation. J Clin Pathol. 1995 Jun;48(6):571–574. doi: 10.1136/jcp.48.6.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Piccaro M., Rastelli D., Lombardo F., Ferrazzani S., Bondoli A., Cagnetta G., Boninsegna A., Moneta E. Quadro reologico e bioumorale nella gravidanza normale e patologica. Minerva Ginecol. 1982 Mar;34(3):111–126. [PubMed] [Google Scholar]
  11. Pickart L. R., Creasy R. K., Thaler M. M. Hyperfibrinogenemia and polycythemia with intrauterine growth retardation in fetal lambs. Am J Obstet Gynecol. 1976 Feb 1;124(3):268–271. doi: 10.1016/0002-9378(76)90155-1. [DOI] [PubMed] [Google Scholar]
  12. Piechota W., Staszewski A. Reference ranges of lipids and apolipoproteins in pregnancy. Eur J Obstet Gynecol Reprod Biol. 1992 Jun 16;45(1):27–35. doi: 10.1016/0028-2243(92)90190-a. [DOI] [PubMed] [Google Scholar]
  13. Potter J. M., Nestel P. J. The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol. 1979 Jan 15;133(2):165–170. doi: 10.1016/0002-9378(79)90469-1. [DOI] [PubMed] [Google Scholar]
  14. Stegnar M., Zore A., Novak-Antolic Z., Vovk N., Kruithof E. K. Tissue-type plasminogen activator after venous occlusion in pregnancy and puerperium. Thromb Haemost. 1993 Sep 1;70(3):486–490. [PubMed] [Google Scholar]
  15. Takayama M., Itoh S., Nagasaki T., Tanimizu I. A new enzymatic method for determination of serum choline-containing phospholipids. Clin Chim Acta. 1977 Aug 15;79(1):93–98. doi: 10.1016/0009-8981(77)90465-x. [DOI] [PubMed] [Google Scholar]
  16. Thorburn J., Drummond M. M., Whigham K. A., Lowe G. D., Forbes C. D., Prentice C. R., Whitfield C. R. Blood viscosity and haemostatic factors in late pregnancy, pre-eclampsia and fetal growth retardation. Br J Obstet Gynaecol. 1982 Feb;89(2):117–122. doi: 10.1111/j.1471-0528.1982.tb04676.x. [DOI] [PubMed] [Google Scholar]
  17. Walsh S. W., Wang Y. Secretion of lipid peroxides by the human placenta. Am J Obstet Gynecol. 1993 Dec;169(6):1462–1466. doi: 10.1016/0002-9378(93)90419-j. [DOI] [PubMed] [Google Scholar]
  18. Yedgar S., Vlodavsky I., Panet A., Reisfeld N., Eldor A. Interferon enhances phospholipase A2 activity in bovine aortic endothelial cells. Eicosanoids. 1990;3(4):225–229. [PubMed] [Google Scholar]

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