Abstract
AIMS: To evaluate the ability of histopathologists to sub-classify non-small cell lung carcinomas on bronchial biopsy material using the current World Health Organisation (WHO) classification. METHODS: Twelve histopathologists each reviewed 100 randomly selected bronchial biopsy specimens which had originally been reported as showing non-small cell lung carcinoma. For each case, two sections were circulated, one stained by haematoxylin and eosin and the other by a standard method for mucin (alcian blue/periodic acid Schiff). The participants were allowed to indicate their degree of confidence in their classification of each case. A standard proforma was completed and the results were analysed using kappa statistics. RESULTS: Where the participants were confident in their classification, they were actually quite good at sub-classifying the non-small cell carcinoma sections (kappa = 0.71, standard error = 0.058). Overall, however, the results were only fair (kappa = 0.39, standard error = 0.034). CONCLUSIONS: The majority of non-small cell lung carcinomas can be correctly categorised on adequate bronchial biopsy material. Where a confident diagnosis was made, both squamous carcinoma (kappa = 0.73) and adenocarcinoma (kappa = 0.83) were well recognised.
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Selected References
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- Burnett R. A., Swanson Beck J., Howatson S. R., Lee F. D., Lessells A. M., McLaren K. M., Ogston S., Robertson A. J., Simpson J. G., Smith G. D. Observer variability in histopathological reporting of malignant bronchial biopsy specimens. J Clin Pathol. 1994 Aug;47(8):711–713. doi: 10.1136/jcp.47.8.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chuang M. T., Marchevsky A., Teirstein A. S., Kirschner P. A., Kleinerman J. Diagnosis of lung cancer by fibreoptic bronchoscopy: problems in the histological classification of non-small cell carcinomas. Thorax. 1984 Mar;39(3):175–178. doi: 10.1136/thx.39.3.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robertson A. J., Anderson J. M., Beck J. S., Burnett R. A., Howatson S. R., Lee F. D., Lessells A. M., McLaren K. M., Moss S. M., Simpson J. G. Observer variability in histopathological reporting of cervical biopsy specimens. J Clin Pathol. 1989 Mar;42(3):231–238. doi: 10.1136/jcp.42.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robertson A. J., Beck J. S., Burnett R. A., Howatson S. R., Lee F. D., Lessells A. M., McLaren K. M., Moss S. M., Simpson J. G., Smith G. D. Observer variability in histopathological reporting of transitional cell carcinoma and epithelial dysplasia in bladders. J Clin Pathol. 1990 Jan;43(1):17–21. doi: 10.1136/jcp.43.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roggli V. L., Vollmer R. T., Greenberg S. D., McGavran M. H., Spjut H. J., Yesner R. Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases. Hum Pathol. 1985 Jun;16(6):569–579. doi: 10.1016/s0046-8177(85)80106-4. [DOI] [PubMed] [Google Scholar]
- Thomas J. S., Lamb D., Ashcroft T., Corrin B., Edwards C. W., Gibbs A. R., Kenyon W. E., Stephens R. J., Whimster W. F. How reliable is the diagnosis of lung cancer using small biopsy specimens? Report of a UKCCCR Lung Cancer Working Party. Thorax. 1993 Nov;48(11):1135–1139. doi: 10.1136/thx.48.11.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]