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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: Nature. 2016 Aug 25;536(7617):474–478. doi: 10.1038/nature18952

Figure 3. Mechanistic studies.

Figure 3

(a) Env-specific serum antibody titers in recipient Balb/c mice (N=5/group) following adoptive transfer of varying amounts (high, mid, low) of IgG purified from serum from prM-Env DNA vaccinated mice or naïve mice (sham). (b) Correlates of protective efficacy. (c) Serum viral loads in mice that received adoptive transfer of purified IgG from vaccinated mice and were challenged with ZIKV-BR. (d) Serum viral loads in prM-Env DNA vaccinated mice that were depleted of CD4+ and/or CD8+ T lymphocytes prior to challenge with ZIKV-BR. Red bars reflect medians. P-values reflect t-tests.