Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1996 Mar;49(3):208–212. doi: 10.1136/jcp.49.3.208

Association between sarcoidosis and lymphoma revisited.

M Karakantza 1, E Matutes 1, K MacLennan 1, N T O'Connor 1, P C Srivastava 1, D Catovsky 1
PMCID: PMC500399  PMID: 8675730

Abstract

AIMS: To investigate the relation between sarcoidosis and lymphoma. METHODS: The hospital notes of five patients with sarcoidosis and a lymphoproliferative disorder were reviewed. Histological material on which the diagnoses of sarcoidosis and lymphoma were made was re-analysed. RESULTS: Four of the five patients had well documented sarcoidosis preceding the development of lymphoma by 18 months to 28 years; the fifth patient had lymphoplasmacytic lymphoma with a reactive granuloma reaction. Two patients had chronic sarcoidosis and three were treated with prednisolone. The types of lymphoma were: Hodgkin's disease (n = 1), B cell lymphoma (n = 2) (mantle cell and lymphoplasmacytic/local plasmacytoma) and large granular lymphocyte leukaemia (T cell) (n = 1). CONCLUSIONS: The association between sarcoidosis and lymphoma is confirmed, suggesting that sarcoidosis may be a predisposing factor for the development of a lymphoid malignancy due to disturbance of the immune system. All types of lymphoma may develop. The first case of T cell granular lymphocytic leukaemia in a patient with sarcoidosis has been documented.

Full text

PDF

Images in this article

209Image
on p.209
209Image
on p.209
210Image
on p.210
211Image
on p.211

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brennan N. J., Fennelly J. J., Towers R. P., FitzGerald M. X. Sarcoidosis and lymphoma in the same patient. Postgrad Med J. 1983 Sep;59(695):581–585. doi: 10.1136/pgmj.59.695.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brincker H. Sarcoid reactions and sarcoidosis in Hodgkin's disease and other malignant lymphomata. Br J Cancer. 1972 Apr;26(2):120–123. doi: 10.1038/bjc.1972.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brincker H. Sarcoid reactions in malignant tumours. Cancer Treat Rev. 1986 Sep;13(3):147–156. doi: 10.1016/0305-7372(86)90002-2. [DOI] [PubMed] [Google Scholar]
  4. Brincker H. The sarcoidosis-lymphoma syndrome. Br J Cancer. 1986 Sep;54(3):467–473. doi: 10.1038/bjc.1986.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brincker H., Wilbek E. The incidence of malignant tumours in patients with respiratory sarcoidosis. Br J Cancer. 1974 Mar;29(3):247–251. doi: 10.1038/bjc.1974.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Forrester J. M., Newman L. S., Wang Y., King T. E., Jr, Kotzin B. L. Clonal expansion of lung V delta 1+ T cells in pulmonary sarcoidosis. J Clin Invest. 1993 Jan;91(1):292–300. doi: 10.1172/JCI116184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Frankel W. N., Rudy C., Coffin J. M., Huber B. T. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature. 1991 Feb 7;349(6309):526–528. doi: 10.1038/349526a0. [DOI] [PubMed] [Google Scholar]
  8. Kadin M. E., Donaldson S. S., Dorfman R. F. Isolated granulomas in Hodgkin's disease. N Engl J Med. 1970 Oct 15;283(16):859–861. doi: 10.1056/NEJM197010152831609. [DOI] [PubMed] [Google Scholar]
  9. Mainguene C., Picard O., Audouin J., Le Tourneau A., Jagueux M., Diebold J. An unusual case of mycosis fungoides presenting as sarcoidosis or granulomatous mycosis fungoides. Am J Clin Pathol. 1993 Jan;99(1):82–86. doi: 10.1093/ajcp/99.1.82. [DOI] [PubMed] [Google Scholar]
  10. Masuda R., Toyoshima H., Bandou T., Isoyama T., Matsui Y., Takemura T. Malignant lymphoma of the stomach associated with systemic sarcoidosis. Cancer. 1992 Dec 1;70(11):2592–2596. doi: 10.1002/1097-0142(19921201)70:11<2592::aid-cncr2820701104>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  11. Müller-Quernheim J., Pfeifer S., Männel D., Strausz J., Ferlinz R. Lung-restricted activation of the alveolar macrophage/monocyte system in pulmonary sarcoidosis. Am Rev Respir Dis. 1992 Jan;145(1):187–192. doi: 10.1164/ajrccm/145.1.187. [DOI] [PubMed] [Google Scholar]
  12. Neville E. Sarcoidosis: the clinical problem. Postgrad Med J. 1988 Jul;64(753):531–535. doi: 10.1136/pgmj.64.753.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pforte A., Schiessler A., Gais P., Beer B., Ehlers M., Schütt C., Ziegler-Heitbrock H. W. Expression of CD14 correlates with lung function impairment in pulmonary sarcoidosis. Chest. 1994 Feb;105(2):349–354. doi: 10.1378/chest.105.2.349. [DOI] [PubMed] [Google Scholar]
  14. Poulter L. W. Immune aspects of sarcoidosis. Postgrad Med J. 1988 Jul;64(753):536–543. doi: 10.1136/pgmj.64.753.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pueringer R. J., Schwartz D. A., Dayton C. S., Gilbert S. R., Hunninghake G. W. The relationship between alveolar macrophage TNF, IL-1, and PGE2 release, alveolitis, and disease severity in sarcoidosis. Chest. 1993 Mar;103(3):832–838. doi: 10.1378/chest.103.3.832. [DOI] [PubMed] [Google Scholar]
  16. Reich J. M. Acute myeloblastic leukemia and sarcoidosis. Implications for pathogenesis. Cancer. 1985 Jan 15;55(2):366–369. doi: 10.1002/1097-0142(19850115)55:2<366::aid-cncr2820550212>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  17. Robinson B. W., McLemore T. L., Crystal R. G. Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis. J Clin Invest. 1985 May;75(5):1488–1495. doi: 10.1172/JCI111852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rømer F. K. Case 7-1982: sarcoidosis and cancer. N Engl J Med. 1982 Jun 17;306(24):1490–1490. doi: 10.1056/NEJM198206173062420. [DOI] [PubMed] [Google Scholar]
  19. Striz I., Wang Y. M., Kalaycioglu O., Costabel U. Expression of alveolar macrophage adhesion molecules in pulmonary sarcoidosis. Chest. 1992 Sep;102(3):882–886. doi: 10.1378/chest.102.3.882. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES