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(right). Leukemic allele frequency was maintained during serial transplantations. Pyrosequencing was performed on human CD45+ cells obtained from murine bone marrow to determine the mutant allele frequency of PTPN11 c.C215T (Patient #1, upper panel) and PTPN11 c.G181T (Patient #2, lower panel) in serially transplanted animals. Since the leukemic mutations were heterozygous, a 50% allele frequency corresponds to 100% leukemic cells.
