Abstract
In order to determine the cellular distribution of androgen receptors (AR) in normal liver and to examine whether phenotypic changes occur in a variety of non-neoplastic liver diseases, cryostat sections of explanted livers removed from 52 consecutive patients undergoing orthotopic transplantation were immunostained using an anti-androgen receptor monoclonal antibody. In histologically normal liver, AR was immunolocalised to the nuclei of hepatocytes. The proportion of positive hepatocytes varied from about 50% to greater than 90%. Staining, of variable intensity, was restricted to parenchymal cells with no evidence of zonal heterogeneity with respect to labelling intensity. In tissue from patients with biliary cirrhoses and in some cases of alcoholic cirrhosis, labelling for AR was observed in areas of ductular metaplasia but not in areas of "typical" ductular reaction (ductular proliferation). Otherwise, no consistent abnormalities in immunolabelling were seen in any of the diseased livers.
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- Eagon P. K., Elm M. S., Stafford E. A., Porter L. E. Androgen receptor in human liver: characterization and quantitation in normal and diseased liver. Hepatology. 1994 Jan;19(1):92–100. [PubMed] [Google Scholar]
- Gleeson D., Newbould M. J., Taylor P., McMahon R. F., Leahy B. C., Warnes T. W. Androgen associated hepatocellular carcinoma with an aggressive course. Gut. 1991 Sep;32(9):1084–1086. doi: 10.1136/gut.32.9.1084. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guéchot J., Peigney N., Ballet F., Vaubourdolle M., Giboudeau J., Poupon R. Effect of D-tryptophan-6-luteinizing hormone-releasing hormone on the tumoral growth and plasma sex steroid levels in cirrhotic patients with hepatocellular carcinoma. Hepatology. 1989 Sep;10(3):346–348. doi: 10.1002/hep.1840100317. [DOI] [PubMed] [Google Scholar]
- Isola J. J. Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. J Pathol. 1993 May;170(1):31–35. doi: 10.1002/path.1711700106. [DOI] [PubMed] [Google Scholar]
- Kahn D., Gavaler J. S., Makowka L., van Thiel D. H. Gender of donor influences outcome after orthotopic liver transplantation in adults. Dig Dis Sci. 1993 Aug;38(8):1485–1488. doi: 10.1007/BF01308608. [DOI] [PubMed] [Google Scholar]
- Matsuura B., Taniguchi Y., Ohta Y. Effect of antiandrogen treatment on chemical hepatocarcinogenesis in rats. J Hepatol. 1994 Aug;21(2):187–193. doi: 10.1016/s0168-8278(05)80393-9. [DOI] [PubMed] [Google Scholar]
- Negro F., Papotti M., Pacchioni D., Galimi F., Bonino F., Bussolati G. Detection of human androgen receptor mRNA in hepatocellular carcinoma by in situ hybridisation. Liver. 1994 Aug;14(4):213–219. doi: 10.1111/j.1600-0676.1994.tb00076.x. [DOI] [PubMed] [Google Scholar]
- Okuda K., Ohtsuki T., Obata H., Tomimatsu M., Okazaki N., Hasegawa H., Nakajima Y., Ohnishi K. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer. 1985 Aug 15;56(4):918–928. doi: 10.1002/1097-0142(19850815)56:4<918::aid-cncr2820560437>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- Ruizeveld de Winter J. A., Janssen P. J., Sleddens H. M., Verleun-Mooijman M. C., Trapman J., Brinkmann A. O., Santerse A. B., Schröder F. H., van der Kwast T. H. Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer. Am J Pathol. 1994 Apr;144(4):735–746. [PMC free article] [PubMed] [Google Scholar]
- Zegers N. D., Claassen E., Neelen C., Mulder E., van Laar J. H., Voorhorst M. M., Berrevoets C. A., Brinkmann A. O., van der Kwast T. H., Ruizeveld de Winter J. A. Epitope prediction and confirmation for the human androgen receptor: generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy. Biochim Biophys Acta. 1991 Jan 23;1073(1):23–32. doi: 10.1016/0304-4165(91)90178-j. [DOI] [PubMed] [Google Scholar]