Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1998 Feb;51(2):167–169. doi: 10.1136/jcp.51.2.167

Increased expression of proliferating cell nuclear antigen in autoimmune hepatitis in a patient with raised serum concentration of CA19-9.

T Sohda 1, Y Iwata 1, H Shijo 1, Y Egashira 1, K Egashira 1, M Okumura 1
PMCID: PMC500516  PMID: 9602695

Abstract

A 52 year old woman had autoimmune hepatitis and an increased concentration of serum carbohydrate antigen 19-9 (CA19-9). The origin of the raised CA19-9 was studied using immunohistochemistry. Liver biopsy section showed chronic active hepatitis with large numbers of proliferated bile ductules. Immunohistochemical analysis revealed that the proliferated bile ductule cells were positive for proliferating cell nuclear antigen (PCNA) and for CA19-9. It is speculated that the raised serum CA19-9 concentration was derived from proliferated bile ductule cells and these cells, which are positive for PCNA, may be able to produce high concentrations of CA19-9.

Full text

PDF
167

Images in this article

167Image
on p.167
168Image
on p.168

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albert M. B., Steinberg W. M., Henry J. P. Elevated serum levels of tumor marker CA19-9 in acute cholangitis. Dig Dis Sci. 1988 Oct;33(10):1223–1225. doi: 10.1007/BF01536670. [DOI] [PubMed] [Google Scholar]
  2. Czaja A. J., Beaver S. J., Wood J. R., Klee G. G., Go V. L. Frequency and significance of serum alpha-fetoprotein elevation in severe hepatitis B surface antigen-negative chronic active hepatitis. Gastroenterology. 1987 Oct;93(4):687–692. doi: 10.1016/0016-5085(87)90429-x. [DOI] [PubMed] [Google Scholar]
  3. Hall P. A., Levison D. A., Woods A. L., Yu C. C., Kellock D. B., Watkins J. A., Barnes D. M., Gillett C. E., Camplejohn R., Dover R. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol. 1990 Dec;162(4):285–294. doi: 10.1002/path.1711620403. [DOI] [PubMed] [Google Scholar]
  4. Kawa S., Tokoo M., Hasebe O., Hayashi K., Imai H., Oguchi H., Kiyosawa K., Furuta S., Homma T. Comparative study of CA242 and CA19-9 for the diagnosis of pancreatic cancer. Br J Cancer. 1994 Sep;70(3):481–486. doi: 10.1038/bjc.1994.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mackay I. R., Weiden S., Hasker J. Autoimmune hepatitis. Ann N Y Acad Sci. 1965 Jun 30;124(2):767–780. doi: 10.1111/j.1749-6632.1965.tb19000.x. [DOI] [PubMed] [Google Scholar]
  6. Satomura Y., Sawabu N., Takemori Y., Ohta H., Watanabe H., Okai T., Watanabe K., Matsuno H., Konishi F. Expression of various sialylated carbohydrate antigens in malignant and nonmalignant pancreatic tissues. Pancreas. 1991 Jul;6(4):448–458. doi: 10.1097/00006676-199107000-00012. [DOI] [PubMed] [Google Scholar]
  7. Steinberg W. M., Gelfand R., Anderson K. K., Glenn J., Kurtzman S. H., Sindelar W. F., Toskes P. P. Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas. Gastroenterology. 1986 Feb;90(2):343–349. doi: 10.1016/0016-5085(86)90930-3. [DOI] [PubMed] [Google Scholar]
  8. Steinberg W. The clinical utility of the CA 19-9 tumor-associated antigen. Am J Gastroenterol. 1990 Apr;85(4):350–355. [PubMed] [Google Scholar]
  9. Turtel P. S., Kreel I., Israel J., Frager D., Berman D. Elevated CA19-9 in a case of Mirizzi's syndrome. Am J Gastroenterol. 1992 Mar;87(3):355–357. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES